19787-1-AP

antibody from Proteintech Group

Targeting: ATR FRP1, MEC1, SCKL, SCKL1

Provider product page for 19787-1-AP

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ELISA

Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Validations
Western blot [1]

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Product number: 19787-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19787-1-AP, RRID:AB_10639516
Product name: ATR antibody
Antibody type: Polyclonal
Description: KD/KO validated ATR antibody (Cat. #19787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ATR protein structure - 19787-1-AP shown in red.

Submitted references 5-FU promotes HBV replication through oxidative stress-induced autophagy dysfunction.

Yang J, Zheng L, Yang Z, Wei Z, Shao J, Zhang Y, Yao J, Li M, Wang X, Zheng M
Free radical biology & medicine 2024 Mar;213:233-247

Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage.

Liu J, Tan X, Li L, Cao L, Zhou Y, Li H, Peng T
Cell death discovery 2024 Mar 11;10(1):130

CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.

Lyu F, Huang S, Yan Z, He Q, Liu C, Cheng L, Cong Y, Chen K, Song Y, Xing Y
Cellular signalling 2024 Jul;119:111164

RP11-789C1.1 inhibits gastric cancer cell proliferation and accelerates apoptosis via the ATR/CHK1 signaling pathway.

Liu W, Feng W, Zhang Y, Lei T, Wang X, Qiao T, Chen Z, Song W
Chinese medical journal 2024 Aug 5;137(15):1835-1843

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.

Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209

The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin.

Su H, Yuan Y, Tang J, Zhang Y, Wu H, Zhang Y, Liang J, Wang L, Zou X, Huang S, Zhang S, Lv Y
Translational oncology 2023 Oct;36:101743

ADAR1 links R-loop homeostasis to ATR activation in replication stress response.

Zhang B, Li Y, Zhang J, Wang Y, Liang C, Lu T, Zhang C, Liu L, Qin Y, He J, Zhao X, Yu J, Hao J, Yang J, Li MJ, Yao Z, Ma S, Cheng H, Cheng T, Shi L
Nucleic acids research 2023 Nov 27;51(21):11668-11687

Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.

Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, Chen Z, Li Y, Xu L, Zhou Y, Zuo Z, Liu C, Wang L, Liu X, Tian X, Su N, Yang Z, Zhang Y, Gou K, Sang N, Liu H, Zou J, Xiao Y, Zhong X, Xu J, Yang X, Xiao K, Liu Y, Yang S, Peng Y, Han J, Cen X, Zhao Y
Nature communications 2023 Nov 16;14(1):7430

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Zhao M, Li Y, Lu C, Ding F, Xu M, Ge X, Li M, Wang Z, Yin J, Zhang J, Wang X, Ge Z, Xiao H, Xiao Y, Liu H, Liu W, Cao Y, Wang Q, You Y, Wang X, Yang K, Shi Z, Qian X
Cancer research 2023 Apr 4;83(7):1094-1110

The Interplay of Four Main Pathways Recomposes Immune Landscape in Primary and Metastatic Gastroenteropancreatic Neuroendocrine Tumors.

Lou X, Gao H, Xu X, Ye Z, Zhang W, Wang F, Chen J, Zhang Y, Chen X, Qin Y, Yu X, Ji S
Frontiers in oncology 2022;12:808448

Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.

Xiong L, Huang J, Wang S, Yuan Q, Yang D, Zheng Z, Wu Y, Wu C, Gao Y, Zou L, Hu G
Archives of toxicology 2022 Mar;96(3):767-781

Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.

Sun Z, Zhang Z, Wang QQ, Liu JL
Cancer research 2022 Mar 15;82(6):1013-1024

Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).

Shi F, Zhang Z, Cui H, Wang J, Wang Y, Tang Y, Yang W, Zou P, Ling X, Han F, Liu J, Chen Q, Liu C, Cao J, Ao L
Ecotoxicology and environmental safety 2022 Jun 15;238:113569

STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.

Xiao S, Liang R, Lucero E, McConnell BK, Chen Z, Chang J, Navran S, Schwartz RJ, Iyer D
The journal of cardiovascular aging 2022 Jul;2(3)

Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA-miRNA network.

Huang ZH, Wang H, Wang DM, Zhao XY, Liu WW, Zhong X, He DM, Mu BR, Lu MH
Journal of cellular and molecular medicine 2022 Dec;26(23):5779-5793

Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.

Wen C, Ruan Q, Li Z, Zhou X, Yang X, Xu P, Akuetteh PDP, Xu Z, Deng J
British journal of cancer 2022 Dec;127(12):2108-2117

Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death.

Yang L, Chen W, Li L, Xiao Y, Fan S, Zhang Q, Xia T, Li M, Hong Y, Zhao T, Li Q, Liu WH, Xiao N
Frontiers in immunology 2021;12:722273

Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.

Cao L, Xu C, Yi P, Li H, Lin Y, Cai G, Wang S, Ou D, Li M, Chen J
American journal of cancer research 2021;11(4):1206-1225

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.

Guo Z, Wang YH, Xu H, Yuan CS, Zhou HH, Huang WH, Wang H, Zhang W
Cell death & disease 2021 Jan 4;12(1):69

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Zhou S, Dai Z, Wang L, Gao X, Yang L, Wang Z, Wang Q, Liu Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169

Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis.

Zhang EB, Zhang X, Wang K, Zhang F, Chen TW, Ma N, Ni QZ, Wang YK, Zheng QW, Cao HJ, Xia J, Zhu B, Xu S, Ding X, Wang X, Li Z, Cheng S, Xie D, Li JJ
Oncogene 2021 Aug;40(34):5302-5313

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222

Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.

Jin J, Li X, Guo W, Li F, Huang J, Huang X, Pan J, Huang S, Ye W, Ling Q, Jin J
Oncology reports 2020 Jul;44(1):273-282

Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver.

Wu Y, Feng W, Liu R, Xia T, Liu S
ACS nano 2020 Jan 28;14(1):877-890

Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.

Guo J, Zhang J, Liang L, Liu N, Qi M, Zhao S, Su J, Liu J, Peng C, Chen X, Liu H
Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340

A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.

Jin J, Mao S, Li F, Li X, Huang X, Yu M, Guo W, Jin J
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.

Liu M, Zeng T, Zhang X, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ, Wang HR
Nature communications 2018 Oct 8;9(1):4139

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9

Methylmalonic aciduria cblB type: characterization of two novel mutations and mitochondrial dysfunction studies.

Brasil S, Richard E, Jorge-Finnigan A, Leal F, Merinero B, Banerjee R, Desviat LR, Ugarte M, Pérez B
Clinical genetics 2015 Jun;87(6):576-81

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ATR antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ATR. This antibody recognizes human,mouse,rat antigen. The ATR antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19787-1-AP.pdf

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