ABIN401401

antibody from antibodies-online

Targeting: ATR FRP1, MEC1, SCKL, SCKL1

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN401401

Provider

antibodies-online

Product name

anti-Ataxia Telangiectasia and Rad3 Related (ATR) antibody

Antibody type

Polyclonal

Antigen

Ataxia Telangiectasia and Rad3 Related (ATR)

Reactivity

Human, Mouse, Rat, Canine, Simian, Xenopus

Host

Rabbit

Antigen sequence

Synthetic peptide corresponding to
an internal region of human ATR pro
tein


Isotype

IgG

Vial size

0.1 mg

Concentration

1.28 mg/mL (by UV absorbance at 280 nm)

References

Submitted references

Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.

Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP
The Journal of cell biology 2006 Oct 9;175(1):55-66

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Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.

Bruno T, De Nicola F, Iezzi S, Lecis D, D'Angelo C, Di Padova M, Corbi N, Dimiziani L, Zannini L, Jekimovs C, Scarsella M, Porrello A, Chersi A, Crescenzi M, Leonetti C, Khanna KK, Soddu S, Floridi A, Passananti C, Delia D, Fanciulli M
Cancer cell 2006 Dec;10(6):473-86

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RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.

Olson E, Nievera CJ, Klimovich V, Fanning E, Wu X
The Journal of biological chemistry 2006 Dec 22;281(51):39517-33

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA
The EMBO journal 2006 Dec 13;25(24):5775-82

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The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer.

Mishra L, Shetty K, Tang Y, Stuart A, Byers SW
Oncogene 2005 Aug 29;24(37):5775-89