AMM01903G

antibody from Leading Biology

Targeting: ATR FRP1, MEC1, SCKL, SCKL1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

AMM01903G

Provider

Leading Biology

Product name

ATR Antibody (clone 1E9)

Antibody type

Monoclonal

Description

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Reactivity

Human

Host

Mouse

Antibody clone number

1E9

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.