PTGIR

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

Description

prostaglandin I2 (prostacyclin) receptor (IP)

Protein family

FDA approved drug targets, G-protein coupled receptors, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Protein evidence (Kim et al 2014)

Chromosome

19:q13.32 (46620468 - 46625118)

Ensembl ID

ENSG00000160013  (ver. 84.38)

Orthologs

Mouse Ptgir: ENSMUSG00000043017

UniProt

P43119

neXtProt

NX_P43119

Human splice variants
Mouse splice variants