HPA006111

antibody from Atlas Antibodies

Targeting: NFIA KIAA1439, NFI-L

Provider product page for HPA006111

Western blot

Immunocytochemistry

Immunohistochemistry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Chromatin Immunoprecipitation [1]

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Product number: HPA006111 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA006111, RRID:AB_1854422
Product name: Anti-NFIA
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human NFIA, Gene description: nuclear factor I/A, Alternative Gene Names: KIAA1439, NFI-L, Validated applications: ChIP, ICC, IHC, WB, Uniprot ID: Q12857, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

NFIA protein structure - HPA006111 shown in red.

Submitted references Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice

Rowland M, Jiang Y, Shafiq S, Ghahramani A, Pena-Ortiz M, Dumeaux V, Bérubé N
Nature Communications 2023;14(1)

NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis

Hiraike Y, Saito K, Oguchi M, Wada T, Toda G, Tsutsumi S, Bando K, Sagawa J, Nagano G, Ohno H, Kubota N, Kubota T, Aburatani H, Kadowaki T, Waki H, Yanagimoto S, Yamauchi T
Proceedings of the National Academy of Sciences 2023;120(31)

Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression

Dai D, Li M, Lee E
Acta Neuropathologica Communications 2023;11(1)

Injury primes mutation-bearing astrocytes for dedifferentiation in later life.

Simpson Ragdale H, Clements M, Tang W, Deltcheva E, Andreassi C, Lai AG, Chang WH, Pandrea M, Andrew I, Game L, Uddin I, Ellis M, Enver T, Riccio A, Marguerat S, Parrinello S
Current biology : CB 2023 Mar 27;33(6):1082-1098.e8

Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma.

de Alwis R, Schoch S, Islam M, Möller C, Ljungberg B, Axelson H
The journal of pathology. Clinical research 2023 Jul;9(4):261-272

Scavuzzo M, Letai K, Maeno-Hikichi Y, Wulftange W, Shah I, Rameshbabu J, Tomar A, Shick H, Shah A, Xiong Y, Cohn E, Allan K, Tesar P
2023

Cheng Y, Luna-Figueroa E, Woo J, Chen H, Lee Z, Harmanci A, Deneen B
2023

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing

Akdemir E, Woo J, Bosquez Huerta N, Lozzi B, Groves A, Harmanci A, Deneen B
The Journal of Neuroscience 2022;42(4):567-580

NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes

Hiraike Y, Tsutsumi S, Wada T, Oguchi M, Saito K, Nakamura M, Ota S, Koebis M, Nakao H, Aiba A, Nagano G, Ohno H, Oki K, Yoneda M, Kadowaki T, Aburatani H, Waki H, Yamauchi T
iScience 2022;25(8):104729

Nuclear Factor I in neurons, glia and during the formation of Müller glia-derived progenitor cells in avian, porcine and primate retinas.

El-Hodiri HM, Campbell WA, Kelly LE, Hawthorn EC, Schwartz M, Jalligampala A, McCall MA, Meyer K, Fischer AJ
The Journal of comparative neurology 2022 Jun;530(8):1213-1230

Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds

Sardar D, Lozzi B, Woo J, Huang T, Cvetkovic C, Creighton C, Krencik R, Deneen B
International Journal of Molecular Sciences 2021;22(8):3975

Capicua regulates the development of adult-born neurons in the hippocampus

Hourigan B, Balay S, Yee G, Sharma S, Tan Q
Scientific Reports 2021;11(1)

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation

Conlon F, Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T
PLOS Genetics 2020;16(9):e1009044

Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities

Huang A, Woo J, Sardar D, Lozzi B, Bosquez Huerta N, Lin C, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B
Neuron 2020;106(6):992-1008.e9

Cep215 is essential for morphological differentiation of astrocytes

Kang D, Shin W, Yoo H, Kim S, Lee S, Rhee K
Scientific Reports 2020;10(1)

Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury

Laug D, Huang T, Huerta N, Huang A, Sardar D, Ortiz-Guzman J, Carlson J, Arenkiel B, Kuo C, Mohila C, Glasgow S, Lee H, Deneen B
Journal of Clinical Investigation 2019;129(10):4408-4418

Sequentially acting SOX proteins orchestrate astrocyte‐ and oligodendrocyte‐specific gene expression

Klum S, Zaouter C, Alekseenko Z, Björklund Å, Hagey D, Ericson J, Muhr J, Bergsland M
EMBO reports 2018;19(11)

DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina

Keeley P, Reese B
Journal of Comparative Neurology 2017;526(3):467-479

Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury

Doi T, Ogata T, Yamauchi J, Sawada Y, Tanaka S, Nagao M
The Journal of Neuroscience 2017;37(43):10290-10309

Zbtb20 promotes astrocytogenesis during neocortical development

Nagao M, Ogata T, Sawada Y, Gotoh Y
Nature Communications 2016;7(1)

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: ChIP-Exo-Seq composite graph for Anti-NFIA (HPA006111 , Lot 000007218) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.