12102-1-AP

antibody from Proteintech Group

Targeting: PBXIP1 HPIP

Provider product page for 12102-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [12]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 12102-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12102-1-AP, RRID:AB_2160484
Product name: PBXIP1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PBXIP1 antibody (Cat. #12102-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PBXIP1 protein structure - 12102-1-AP shown in red.

Submitted references HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.

Jiang Q, Zhang D, Liu J, Liang C, Yang R, Zhang C, Wu J, Lin J, Ye T, Ding L, Li J, Gao S, Li B, Ye Q
Science advances 2023 Jun 9;9(23):eade1155

A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.

Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198

INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation.

Ruan XH, Liu XM, Yang ZX, Zhang SP, Li QZ, Lin CS
OncoTargets and therapy 2019;12:3109-3117

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.

Ji Q, Xu X, Kang L, Xu Y, Xiao J, Goodman SB, Zhu X, Li W, Liu J, Gao X, Yan Z, Zheng Y, Wang Z, Maloney WJ, Ye Q, Wang Y
Nature communications 2019 Jan 18;10(1):313

The interplay between HPIP and casein kinase 1α promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.

Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, Yan Z, Li Y, Liang Y, Li L, Jin S, You W, Ma Y, Chen L, Ye Q
Oncogenesis 2016 Oct 3;5(10):e260

HPIP promotes gastric cancer cell proliferation through activation of cap-dependent translation.

Chen B, Zhao J, Zhang S, Zhang Y, Huang Z
Oncology reports 2016 Dec;36(6):3664-3672

HPIP promotes thyroid cancer cell growth, migration and EMT through activating PI3K/AKT signaling pathway.

Wang SC, Chai DS, Chen CB, Wang ZY, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Oct;75:33-9

Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.

Feng Y, Li L, Zhang X, Zhang Y, Liang Y, Lv J, Fan Z, Guo J, Hong T, Ji B, Ji Q, Mei G, Ding L, Zhang S, Xu X, Ye Q
Cancer science 2015 Oct;106(10):1313-22

HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion.

Feng Y, Xu X, Zhang Y, Ding J, Wang Y, Zhang X, Wu Z, Kang L, Liang Y, Zhou L, Song S, Zhao K, Ye Q
Scientific reports 2015 Mar 24;5:9429

MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.

Shostak K, Patrascu F, Göktuna SI, Close P, Borgs L, Nguyen L, Olivier F, Rammal A, Brinkhaus H, Bentires-Alj M, Marine JC, Chariot A
Cell death and differentiation 2014 May;21(5):811-24

HPIP is upregulated in liver cancer and promotes hepatoma cell proliferation via activation of G2/M transition.

Xu X, Jiang C, Wang S, Tai Y, Wang T, Kang L, Fan Z, Li S, Li L, Fu J, Liu J, Ji Q, Wang X, Wei L, Ye Q
IUBMB life 2013 Oct;65(10):873-82

Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.

Xu X, Fan Z, Kang L, Han J, Jiang C, Zheng X, Zhu Z, Jiao H, Lin J, Jiang K, Ding L, Zhang H, Cheng L, Fu H, Song Y, Jiang Y, Liu J, Wang R, Du N, Ye Q
The Journal of clinical investigation 2013 Feb;123(2):630-45

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 12102-1-AP(PBXIP1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PBXIP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PBXIP1. This antibody recognizes human antigen. The PBXIP1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 12102-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 12102-1-AP(PBXIP1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue