11582-1-AP

antibody from Proteintech Group

Targeting: PLSCR1 MMTRA1B

Provider product page for 11582-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]
Flow cytometry [1]

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Product number: 11582-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11582-1-AP, RRID:AB_2165659
Product name: PLSCR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PLSCR1 antibody (Cat. #11582-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PLSCR1 protein structure - 11582-1-AP shown in red.

Submitted references Optimized risk stratification strategy for glioma patients based on the feature genes of poor immune cell infiltration patterns.

Wan HT, Su ZJ, Guo ZS, Wen P, Hong XY
Journal of cancer research and clinical oncology 2023 Nov;149(15):13855-13874

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.

Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD
Nature 2023 Jul;619(7971):819-827

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis.

Luo J, Lian Q, Zhu D, Zhao M, Mei T, Shang B, Yang Z, Liu C, Xu W, Zhou L, Wu K, Liu X, Lai Y, Mao F, Li W, Zuo C, Zhang K, Lin M, Zhuo Y, Liu Y, Lu L, Zhao L
Genes & diseases 2023 Jul;10(4):1564-1581

Phospholipid scramblase-1 regulates innate type 2 inflammation in mouse lungs via CRTH2-dependent mechanisms.

Hernandez-Gutierrez A, Majid S, Eberle A, Choi A, Sorkhdini P, Yang D, Yang AX, Norbrun C, He CH, Lee CM, Lee CG, Elias JA, Zhou Y
The Journal of clinical investigation 2023 Aug 1;133(15)

ILDR1 promotes influenza A virus replication through binding to PLSCR1.

Liu Y, Lin S, Xie Y, Zhao L, Du H, Yang S, Yin B, Li G, Zhao Z, Huang Z, Xu Z, Wu J
Scientific reports 2022 May 20;12(1):8515

ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.

Marchetti L, Francisco D, Soldati S, Haghayegh Jahromi N, Barcos S, Gruber I, Pareja JR, Thiriot A, von Andrian U, Deutsch U, Lyck R, Bruggmann R, Engelhardt B
European journal of immunology 2022 Jan;52(1):161-177

Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.

Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ
Cancer science 2022 Jan;113(1):205-220

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851

Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation.

Slone EA, Pope MR, Fleming SD
Journal of leukocyte biology 2015 Nov;98(5):791-804

Interactome map reveals phospholipid scramblase 1 as a novel regulator of hepatitis B virus x protein.

Yuan Y, Tian C, Gong Q, Shang L, Zhang Y, Jin C, He F, Wang J
Journal of proteome research 2015 Jan 2;14(1):154-63

Phospholipid scramblase 1 (PLSCR1) in villous trophoblast of the human placenta.

Berghold VM, Gauster M, Hemmings DG, Moser G, Kremshofer J, Siwetz M, Sundl M, Huppertz B
Histochemistry and cell biology 2015 Apr;143(4):381-96

Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells.

Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J
FEBS letters 2011 Sep 2;585(17):2647-52

Identification of phospholipid scramblase 1 as a biomarker and determination of its prognostic value for colorectal cancer.

Kuo YB, Chan CC, Chang CA, Fan CW, Hung RP, Hung YS, Chen KT, Yu JS, Chang YS, Chan EC
Molecular medicine (Cambridge, Mass.) 2011 Jan-Feb;17(1-2):41-7

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11582-1-AP(PLSCR1 antibody) at dilution of 1:2000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 11582-1-AP(PLSCR1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PLSCR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLSCR1. This antibody recognizes human,mouse,rat antigen. The PLSCR1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
Appendix: 11582-1-AP.pdf

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