11582-1-AP

antibody from Proteintech Group

Targeting: PLSCR1 MMTRA1B

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

11582-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11582-1-AP, RRID:AB_2165659

Product name

PLSCR1 antibody

Antibody type

Polyclonal

Description

KD/KO validated PLSCR1 antibody (Cat. #11582-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection.

Yang AX, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman MJ, Boyd DF, Zhou Y
bioRxiv : the preprint server for biology 2025 Sep 12;

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IFN-inducible Human Phospholipid Scramblase 1 (PLSCR1) Protein Restricts HIV-1 Infection by Inhibiting Membrane Fusion.

Liu Y, Li P, Zheng YM, Hikichi Y, Ablan S, Freed EO, Liu SL
bioRxiv : the preprint server for biology 2025 Jun 24;

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FOXA1 Transcriptional Repression of PLSCR1 Inhibits Tongue Squamous Cell Carcinoma Progression.

Wang J, Zhang C, Wang J, Wang L, Liu L, Duan C
Cell biochemistry and biophysics 2025 Dec;83(4):4551-4566

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Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection.

Yang AX, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman M, Boyd DF, Zhou Y
eLife 2025 Dec 24;14

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A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.

Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH 3rd, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM
PLoS biology 2024 Sep;22(9):e3002767

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C G composition in transposon-derived genes is increased in FXD with perturbed immune system.

Suganuma T, Hassan H, Gogol M, Workman JL
NAR molecular medicine 2024 Oct;1(4):ugae015

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Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses.

Caputo M, Ivanova D, Chasserot-Golaz S, Doussau F, Haeberlé AM, Royer C, Ozkan S, Ecard J, Vitale N, Cousin MA, Tóth P, Gasman S, Ory S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Jul 3;44(27)

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Optimized risk stratification strategy for glioma patients based on the feature genes of poor immune cell infiltration patterns.

Wan HT, Su ZJ, Guo ZS, Wen P, Hong XY
Journal of cancer research and clinical oncology 2023 Nov;149(15):13855-13874

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PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.

Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD
Nature 2023 Jul;619(7971):819-827

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PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis.

Luo J, Lian Q, Zhu D, Zhao M, Mei T, Shang B, Yang Z, Liu C, Xu W, Zhou L, Wu K, Liu X, Lai Y, Mao F, Li W, Zuo C, Zhang K, Lin M, Zhuo Y, Liu Y, Lu L, Zhao L
Genes & diseases 2023 Jul;10(4):1564-1581

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Phospholipid scramblase-1 regulates innate type 2 inflammation in mouse lungs via CRTH2-dependent mechanisms.

Hernandez-Gutierrez A, Majid S, Eberle A, Choi A, Sorkhdini P, Yang D, Yang AX, Norbrun C, He CH, Lee CM, Lee CG, Elias JA, Zhou Y
The Journal of clinical investigation 2023 Aug 1;133(15)

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ILDR1 promotes influenza A virus replication through binding to PLSCR1.

Liu Y, Lin S, Xie Y, Zhao L, Du H, Yang S, Yin B, Li G, Zhao Z, Huang Z, Xu Z, Wu J
Scientific reports 2022 May 20;12(1):8515

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ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.

Marchetti L, Francisco D, Soldati S, Haghayegh Jahromi N, Barcos S, Gruber I, Pareja JR, Thiriot A, von Andrian U, Deutsch U, Lyck R, Bruggmann R, Engelhardt B
European journal of immunology 2022 Jan;52(1):161-177

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Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.

Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ
Cancer science 2022 Jan;113(1):205-220

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Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851

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Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation.

Slone EA, Pope MR, Fleming SD
Journal of leukocyte biology 2015 Nov;98(5):791-804

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Interactome map reveals phospholipid scramblase 1 as a novel regulator of hepatitis B virus x protein.

Yuan Y, Tian C, Gong Q, Shang L, Zhang Y, Jin C, He F, Wang J
Journal of proteome research 2015 Jan 2;14(1):154-63

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Phospholipid scramblase 1 (PLSCR1) in villous trophoblast of the human placenta.

Berghold VM, Gauster M, Hemmings DG, Moser G, Kremshofer J, Siwetz M, Sundl M, Huppertz B
Histochemistry and cell biology 2015 Apr;143(4):381-96

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Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells.

Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J
FEBS letters 2011 Sep 2;585(17):2647-52

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Identification of phospholipid scramblase 1 as a biomarker and determination of its prognostic value for colorectal cancer.

Kuo YB, Chan CC, Chang CA, Fan CW, Hung RP, Hung YS, Chen KT, Yu JS, Chang YS, Chan EC
Molecular medicine (Cambridge, Mass.) 2011 Jan-Feb;17(1-2):41-7

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11582-1-AP(PLSCR1 antibody) at dilution of 1:2000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human pancreas cancer using 11582-1-AP(PLSCR1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The PLSCR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLSCR1. This antibody recognizes human,mouse,rat antigen. The PLSCR1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.

Appendix

11582-1-AP.pdf

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