20350-1-AP

antibody from Proteintech Group

Targeting: SLC1A5 AAAT, ASCT2, M7V1, RDRC

Provider product page for 20350-1-AP

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Antibody data

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Antigen structure
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Product number: 20350-1-AP - Provider product page
Provider: Proteintech Group
Product name: ASCT2 antibody
Antibody type: Polyclonal
Description: ASCT2 antibody (Cat. #20350-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC1A5 protein structure - 20350-1-AP shown in red.

Submitted references Exosomes From Cancer-Associated Fibroblasts Promote Colorectal Cancer Progression and Glutamine Metabolism Through METTL1-Mediated m7G Modification of SLC1A5 mRNA.

Zhang S, Chen Z, Ma C, Hu J, Lin S, Gao J, Chen S
Journal of gastroenterology and hepatology 2026 May;41(5):1541-1555

Targeting ROS-metabolism dual pathways to trigger PANoptosis by cobalt-vanadium oxides biomimetic nanocakes for tumor immunotherapy.

Du S, Ma G, Li X, Chao M, Fan L, Zhao Z, Tang R, Li J, Jing C, Liu Y, Yu D, Liu Z, Gao F
Biomaterials 2026 Mar;326:123726

Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types.

Cai L, Zhang Q, Yao T, Zou X, Xie L, Yang S, Xiao Y, Huang F, Peng Z, Yang J, Huang J, Jing Q, Ling Z, Zheng M, Qiao C, Wu J, Chen J, Jiang T, Liu Q, Liu M, Chen Z, Li J, Jiang H, Jiang H, Chen Z, Liao Y, Huang Y, Li L, Zhou Y, Zhang Z, Yin C, Ye Y, Yang H, Chen B, Wang Z, Gong H, Chen D, Huang C, Tong X, Zhou Z, Fu H, Sun Y, Sun X, Yan M, Wu L, Xiong S, Wang Y, Xie X, Zhou M, Liu X, Xie X, Wu F, Liu Z, Ge M, Xiong S, Li C, Shen T, Liu Y, Tang X, Chang X, Liu S, Yu C, Yu N, Hu Z, Cui D, Zhong J, Liu S, Hu J, Wen Y, Zhou W, Wei G, Lin S, Xiahou Y, Chen L, Li J, Liu R, Chen X, Shu Y, Chen F, Wei C, Hu X, Li Y, Hou Y, Zeng Q, Gao J, Su Y, Li J, Ma J, Guo Y, Chen C, Xiao S, Ai H, Zhang Z, Liu W, Yang Q, Xing Y, Rao L, Yang B, Huang L
Science (New York, N.Y.) 2026 Mar 26;391(6792):eadu7265

Targeting the Glutamine Transporter SLC1A5 Enhances Sensitivity of Acute Myeloid Leukemia to MLN4924.

Wang Y, Guo Y, Tang X, Zhu Y, Liang H, Zhang Y, Liu B
Biomedicines 2026 Mar 14;14(3)

Glutamine modified lipid nanoparticles loaded with GPX4 siRNA for cervical cancer targeting.

Chen Y, Zhong L, Chen J, Li X, Lv J, Chen H, Ran R
International journal of biological macromolecules 2026 Jan;336:149419

Li L, Pang J, Chen J, Pan Y, Liang L, Bai X, He Y, Yang H
Medicine 2026 Jan 23;105(4):e47262

HHLA2 promotes immune evasion in EGFR-mutant lung cancer by inhibiting CD8(+) T cell glutamine metabolism via KIR3DL3 interaction.

Wu F, Shen J, Zhao Z, Chen Y, Ren B, Li M, Yin R, Zhang Y, Yu S
Cancer letters 2026 Feb 28;639:218219

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Wei S, Pang S, Gu F, Gao K, Ye X, Yang X, Kong Z, Li YY, Jiang Z, Wang L, Xiao H
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6505-6518

ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC.

Deng L, Yang X, Zhang J, Zhou X, Ma R, Wu Z, Chen H
Cell death & disease 2026 Feb 17;17(1):227

The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.

Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311

Unveiling membrane transporter proteins-related genes for predicting the prognosis of hepatocellular carcinoma patients.

Xiao Y, Zhang G, Zhao H
Discover oncology 2026 Feb 12;17(1)

Alanine-serine-cysteine transporter-targeted small-molecule boron carriers for neutron capture therapy of L-4‑boronophenylalanine-refractory tumors.

Miura K, Araki T, Morita T, Nishimura K, Okada S, Suzuki M, Nakamura H
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114566

Real-Time Tracking of ASCT2-Mediated Glutamine Uptake in Living Tumors With a Bioorthogonal Bioluminescent Probe.

Zhou BJ, Zhao JL, Yin F, Chen WD, Sun Y, Ren YY, Chen YM, Xie T, Duan C, Zhou JL
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e07057

SLAMF7 promotes TCRαβ(+) double negative T cell antitumor activity through enhancing glutamine metabolism.

Xu N, Fang P, Zhou L, Han X, Jiang Y, Wang X, Zhu J, Li B, Zhang Z, Jin H, Du X, Sun G, Zhang D
Journal of experimental & clinical cancer research : CR 2025 Oct 30;44(1):297

Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal.

Li X, Qin X, Zhao X, Liu Y, Wang L, Li K, Li J, Ma J, Dai L, Hasim A
Journal of advanced research 2025 Nov 16;

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study.

Ding X, Zhang E, Huang Z, Li X, Wang Z, Wu Y, Liu C, Wu S
Journal of translational medicine 2025 Nov 13;23(1):1277

Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.

Fan TW, Yan J, Goncalves CFL, Islam JMM, Lin P, Kaddah MMY, Higashi RM, Lane AN, Wang X, Zhu C
The Journal of biological chemistry 2025 May;301(5):108495

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures.

Yu F, Chen C, Liu W, Zhao Z, Fan Y, Li Z, Huang W, Xie T, Luo C, Yao Z, Guo Q, Yang Z, Liu J, Zhang Y, Kellems RE, Xia J, Li J, Xia Y
Aging cell 2025 May;24(5):e14482

PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.

Rao X, Allison DB, Flight RM, Lin P, He D, Li Z, Zhang Y, Wang R, Li C, Wang J, Wang X, Peng J, Fong KW, Shao Q, Wang C, Ali ES, Moseley HN, Liu X
bioRxiv : the preprint server for biology 2025 May 24;

Long-term leucine supplementation increases body weight in goats by controlling appetite and muscle protein synthesis under protein-restricted conditions.

Lv X, Jiang A, Hua J, Liu Z, Yan Q, Tang S, Kang J, Tan Z, Wu J, Zhou C
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Mar;20:404-418

The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis.

Pu X, Wu Y, Long W, Sun X, Yuan X, Wang D, Wang X, Xu M
Cancer cell international 2025 Mar 29;25(1):122

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease.

Chen J, Hadi F, Wen X, Zhao W, Xu M, Xue S, Lin P, Calandrelli R, Richard JLC, Song Z, Li J, Amani A, Liu Y, Chen X, Zhong S
Cell 2025 Jun 26;188(13):3513-3529.e26

Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.

Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9

NKD1 enhances colon cancer progression by inhibiting the autophagic degradation of MYC.

Lu W, Tang J, Wang Y, Gu X, Zhang H, Liu Y, Xiao Y, Zhu Q, Deng J, Shen Y, Jiang A, Xu Y, Jin J, Hou Y, Liu Q
Cell death & disease 2025 Jul 17;16(1):532

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy.

Cheng J, Sun M, Dong X, Yang Y, Qin X, Zhou X, Fu Y, Wang Y, Wang J, Zhang D
BMC cancer 2025 Jan 28;25(1):161

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism.

Wu X, Li Y, Wang W, Xu J, Zhao B, Sun W, Ge D, Xiong L, Dou X, Zou X, Wang L, Chen M
Scientific reports 2025 Jan 28;15(1):3542

V9302-loaded copper-polyphenol hydrogel for enhancing the anti-tumor effect of disulfiram.

Sun Z, Wei S, Guo Q, Ouyang H, Mao Z, Wang W, Tong Z, Ding Y
Journal of colloid and interface science 2025 Jan 15;678(Pt B):866-877

Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer.

Li J, Zhang D, Wang S, Yu P, Sun J, Zhang Y, Meng X, Li J, Xiang L
Journal of advanced research 2025 Feb;68:341-357

Inhibition of integrin α3 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake.

Zhu W, Pan S, Xu J, Wang Y, Fu Z, Han X, Zhang Y, Zhao Q, Zhang R, Hu C, Xu Z
Journal of gastroenterology 2025 Dec;60(12):1496-1512

Increased maternal valine intake in low-protein diets accelerates growth performance of suckling piglets by improving mammary gland-fetal intestinal metabolism.

Wei S, Ye X, Gu F, Gao K, Wang L, Yang X, Jiang Z, Deng J, Xiao H
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Dec;23:304-315

NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.

Li J, Meng F, Qian X, Chen S
Scientific reports 2025 Dec 23;16(1):2568

Targeting Glutamine Transporters as a Novel Drug Therapy for Synovial Sarcoma.

Thanh TD, Takada N, Yao H, Ban Y, Oebisu N, Hoshi M, Sang NTQ, Khanh NV, Quang DM, Thuy LTT, Dung TT, Terai H
Cancers 2025 Dec 19;18(1)

TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation.

Zhao J, Yang F, Zhang Y, Wang H, Kwok CK
Nucleic acids research 2025 Aug 27;53(16)

Gut-resident Phascolarctobacterium succinatutens decreases fat accumulation via MYC-driven epigenetic regulation of arginine biosynthesis.

Lan Q, Liufu S, Chen B, Wang K, Chen W, Xiao L, Liu X, Yi L, Liu J, Xu X, Liu C, Liu M, Yin Y, Ma H
NPJ biofilms and microbiomes 2025 Aug 2;11(1):150

Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling.

Zhang Y, Ren Y, Wang Z, Zhang X, Li X, Yu Y, Qian L, Xiong Y
Free radical biology & medicine 2025 Aug 1;235:25-42

Mechanism Study of E2F8 Activation of SPC25-Mediated Glutamine Metabolism Promoting Immune Escape in Lung Adenocarcinoma.

Luo M, Xie L, Lin B, Su X, Liang R, Ma Z, Li Y
Immunology 2025 Apr;174(4):450-461

HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration.

Yang Y, Gao C, Li Q, Liu Y, Cao J
Toxicology 2024 Sep;507:153899

The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine.

Shi X, Zhang Y, Wang Y, Wang J, Gao Y, Wang R, Wang L, Xiong M, Cao Y, Ou N, Liu Q, Ma H, Cai J, Chen H
Cell death and differentiation 2024 Sep;31(9):1219-1234

Integrated machine learning screened glutamine metabolism-associated biomarker SLC1A5 to predict immunotherapy response in hepatocellular carcinoma.

Zhang G, Xiao Y, Liu H, Wu Y, Xue M, Li J
Immunobiology 2024 Sep;229(5):152841

Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex.

Xiao C, Li Y, Liu Y, Dong R, He X, Lin Q, Zang X, Wang K, Xia Y, Kong L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2401748

Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.

Chen Y, Xu W, Jin H, Zhang M, Liu S, Liu Y, Zhang H
ACS nano 2024 Nov 19;18(46):31846-31868

Modulation of SRC by SNTB1 activates the Hippo-YAP pathway during colon adenocarcinoma metastasis.

Chang Z, Huang R, Song J, Li Z, Pi M, Xian S, Zhang J, Huang J, Xie R, Ji G, Han D, Huang Q
Journal of translational medicine 2024 Nov 15;22(1):1029

Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy.

Zhao Y, Liu Z, Deng K, Qu H, Zhang Q, Zhou P, Yang M, Yang X, Wang H, Li R, Xia J
International immunopharmacology 2024 May 10;132:111998

Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.

Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B
Journal of translational medicine 2024 Mar 7;22(1):247

Progesterone inhibits endometrial cancer growth by inhibiting glutamine metabolism through ASCT2.

Guo J, Fan J, Zhang Y, Li M, Jin Z, Shang Y, Zhang H, Kong Y
Bioscience reports 2024 Mar 29;44(3)

PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism.

Liu H, Tian H, Hao P, Du H, Wang K, Qiu Y, Yin X, Wu N, Du Q, Tong D, Huang Y
PLoS pathogens 2024 Jun;20(6):e1012305

Elevated SLC1A5 associated with poor prognosis and therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma.

Zhang G, Xiao Y, Tan J, Liu H, Fan W, Li J
Journal of translational medicine 2024 Jun 6;22(1):543

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J
Nature communications 2024 Jun 3;15(1):4703

Biomimetic Nanomedicine Targeting Orchestrated Metabolism Coupled with Regulatory Factors to Disrupt the Metabolic Plasticity of Breast Cancer.

Meng L, Yang J, Gao Y, Cao Q, Jiang S, Xiao Y, Wang H, Liu W, Yuan A, Li Y, Huang H
ACS nano 2024 Feb 6;18(5):4360-4375

KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5-Mediated Tryptophan Metabolism.

Chai B, Zhang A, Liu Y, Zhang X, Kong P, Zhang Z, Guo Y
Journal of cellular and molecular medicine 2024 Dec;28(23):e70245

Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis.

Li R, Li N, Yang Q, Tong X, Wang W, Li C, Zhao J, Jiang D, Huang H, Fang C, Xie K, Yuan J, Chen S, Li G, Luo H, Gao Z, Wu D, Cui X, Jiang W, Guo L, Ma H, Feng Y
Genome medicine 2024 Dec 18;16(1):148

Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.

Bian Y, Yin G, Wang G, Liu T, Liang L, Yang X, Zhang W, Tang D
Cell biology and toxicology 2023 Oct;39(5):1957-1978

Therapeutic applications of local injection of hsa-miR-634 into canine spontaneous malignant melanoma tumors.

Yoshikawa R, Inoue J, Iwasaki R, Terauchi M, Fujii Y, Ohta M, Hasegawa T, Mizuno R, Mori T, Inazawa J
Cancer gene therapy 2023 Nov;30(11):1524-1529

ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.

Hu Q, Dai J, Zhang Z, Yu H, Zhang J, Zhu X, Qin Y, Zhang L, Zhang P
Cancer research 2023 May 15;83(10):1646-1665

Zheng S, Liu T, Li L, Liu Q, Huang C, Liang Y, Tan Y, Zhang L, Lu X
Heliyon 2023 Mar;9(3):e14571

A pan-cancer analysis of SLC1A5 in human cancers.

Ni J, Dai W, Liu C, Ling Y, Mou H
Heliyon 2023 Jun;9(6):e17598

Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4(+) T cells through the regulation of glutamine influx via direct interaction with ASCT2.

Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S
International immunopharmacology 2023 Feb;115:109617

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.

Wang S, Lin Y, Gao L, Yang Z, Lin J, Ren S, Li F, Chen J, Wang Z, Dong Z, Sun P, Wu B
Theranostics 2022;12(4):1589-1606

Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma.

Tran PX, Inoue J, Harada H, Inazawa J
Molecular therapy oncolytics 2022 Mar 17;24:897-908

HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation.

He Z, Gao Y, Li T, Yu C, Ou L, Luo C
International journal of oncology 2022 Apr;60(4)

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.

Ye D, Xu H, Xia H, Zhang C, Tang Q, Bi F
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173

Augmentation of lenvatinib efficacy by topical treatment of miR-634 ointment in anaplastic thyroid cancer.

Kishikawa M, Inoue J, Hamamoto H, Kobayashi K, Asakage T, Inazawa J
Biochemistry and biophysics reports 2021 Jul;26:101009

Hu Y, Tu Z, Lei K, Huang K, Zhu X
Bioscience reports 2021 Dec 22;41(12)

The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma.

Lin Y, Jin H, Wu X, Jian Z, Zou X, Huang J, Guan R, Wei X
Aging 2020 Jul 27;12(14):14391-14405

Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment.

Inoue J, Fujiwara K, Hamamoto H, Kobayashi K, Inazawa J
Molecular therapy oncolytics 2020 Dec 16;19:294-307

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