Tissue expression
Cell line expression
Protein structure
PSMC3
Proteasome 26S subunit, ATPase 3TBP-1, TBP1
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 24142-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
antibodies-online | ABIN4880979 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
Invitrogen Antibodies | 24142-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
||
Novus Biologicals | NBP2-61802 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
GeneTex | GTX83774 | Monoclonal |
WB
ICC
IHC
FC |
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