10827-1-AP

antibody from Proteintech Group

Targeting: KAT5 cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10827-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10827-1-AP, RRID:AB_2128431

Product name

KAT5 antibody

Antibody type

Polyclonal

Description

KD/KO validated KAT5 antibody (Cat. #10827-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.

Wang G, Gong G, Yang X, Qian Y, Zhao Y, Li D, Liu M, Xu Z, Zhang F
Journal of advanced research 2026 Mar 9;

---

MRG15 decline in aged/injured MuSCs hinders regeneration via differentiation defects.

Li Z, Ma M, Shen S, Ma R, Kong W, Wu Y, Ding Q, Ying H, Li Y
Cell regeneration (London, England) 2026 Jan 25;15(1):8

---

A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance.

Wang Y, Liu X, Li X, Zhao L, Chen H, Gong X, Xu J, Zhang J, Liu Z, Sun Y
Science translational medicine 2026 Feb 25;18(838):eadz0672

---

Dynamic regulation of K33- and K48-linked ubiquitination of Tip60 by TRIM37 orchestrates host DNA damage response during Pseudomonas aeruginosa infection and recovery.

Yu H, Wang X, Xiong J, He X, Ma C, Wang Q, Chen R, Li Y, Dai Q, Min Q, Zhou J, Zhang K
Microbiological research 2026 Apr;305:128414

---

YEATS2 promotes malignant phenotypes of esophageal squamous cell carcinoma via H3K27ac activated-IL6ST.

Zhai Y, Zhang F, Shi X, Zou S, Hu X, Shan C, Zhang L, Zou B, Yang X, Kong P, Cheng X
Frontiers in cell and developmental biology 2025;13:1497290

---

KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity.

Li Y, Peng L, Zhou Y, You Y, Jiang J, Luo Y
Brain research bulletin 2025 Sep;229:111467

---

Lactylation of CREB is required for FSH-induced proliferation and differentiation of ovarian granulosa cells.

Wu G, Chen M, He T, Pan Y, Li C, Liu Z, Li H, Sheng Y, Dai W, Shen M, Liu H
Nucleic acids research 2025 Sep 5;53(17)

---

Exploration of the mechanism underlying the impact of artificial light on guinea pig ovarian function via proteomics and acetylation analyses.

Shi J, Wang Y, Li L, Wang R, Peng Y, Zhou T, Hu D, Chen J, Tan Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118719

---

Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.

Lin X, Chen W, Li B, Zhao Z, Yu Z, Zhao XY, Zhou X, Feng Z, Lin C, Cao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795

---

P300-dependent acetylation of the FOXQ1 complex activates super-enhancers to promote colorectal cancer proliferation and metastasis.

Yang WD, Zhang ZH, Zhao MY, Shao K, Ma YF, Shen Q, Lu MR, Shao ZY, Xu JY, Cao MH, Meng S, Chu SF, Yong HM, Ding J, Bai J
Communications biology 2025 Jul 7;8(1):1016

---

Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation.

Zhao H, Fu X, Wang Y, Shang Z, Li B, Zhou L, Liu Y, Liu D, Yi B
Molecular nutrition & food research 2025 Feb;69(4):e202400785

---

BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation.

Sun L, Fu X, Xiao Z, Ma G, Zhou Y, Hu H, Shi L, Li D, Jauch R, Hutchins AP
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2409160

---

MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.

Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646

---

TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation.

Sun M, Yang B, Xin G, Wang Y, Luo J, Jiang Q, Zhang C
Science China. Life sciences 2024 Sep;67(9):1957-1969

---

SPIN1 facilitates chemoresistance and HR repair by promoting Tip60 binding to H3K9me3.

Wang Y, Li M, Chen Y, Jiang Y, Zhang Z, Yan Z, Liu X, Wu C
EMBO reports 2024 Sep;25(9):3970-3989

---

Securin acetylation prevents precocious separase activation and premature sister chromatid separation.

Wang T, Zou Y, Meng H, Zheng P, Teng J, Huang N, Chen J
Current biology : CB 2024 Mar 25;34(6):1295-1308.e5

---

GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.

Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
Nature communications 2024 Mar 21;15(1):2531

---

The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex.

Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M
Molecular cell 2024 Jun 6;84(11):2070-2086.e20

---

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.

Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C
Nature 2024 Jul;631(8021):663-669

---

BAP18 acting as a novel peroxisome proliferator-activated receptor α co-regulator contributes to hepatocellular carcinoma progression.

Liu W, Wang S, Lin L, Zou R, Sun H, Zeng K, Wu Y, Li Y, Shigeaki K, Wang X, Wang C, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166974

---

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance.

Zhao Z, Chen Q, Xiang X, Dai W, Fang W, Cui K, Li B, Liu Q, Liu Y, Shen Y, Li Y, Xu W, Mai K, Ai Q
The Journal of cell biology 2024 Dec 2;223(12)

---

Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development.

Zhang E, Yan Q, Sun Y, Li J, Chen L, Zou J, Zeng S, Jiang J, Li J
Journal of proteome research 2024 Aug 2;23(8):3367-3382

---

Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression.

Liu J, Zhai M, Chen Y, Wei Y, Li F, Chen Y, Duan B, Xing L, Du H, Jiang M, Li H, Ren G
Cancer letters 2024 Aug 10;597:217005

---

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.

Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC
Cell research 2023 Nov;33(11):835-850

---

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.

Jia M, Yue X, Sun W, Zhou Q, Chang C, Gong W, Feng J, Li X, Zhan R, Mo K, Zhang L, Qian Y, Sun Y, Wang A, Zou Y, Chen W, Li Y, Huang L, Yang Y, Zhao Y, Cheng X
Science advances 2023 Jun 2;9(22):eadg4993

---

Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.

Liu N, Konuma T, Sharma R, Wang D, Zhao N, Cao L, Ju Y, Liu D, Wang S, Bosch A, Sun Y, Zhang S, Ji D, Nagatoishi S, Suzuki N, Kikuchi M, Wakamori M, Zhao C, Ren C, Zhou TJ, Xu Y, Meslamani J, Fu S, Umehara T, Tsumoto K, Akashi S, Zeng L, Roeder RG, Walsh MJ, Zhang Q, Zhou MM
Molecular cell 2023 Jul 6;83(13):2206-2221.e11

---

Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin.

Zhu Y, Hart GW
Cell 2023 Jan 19;186(2):428-445.e27

---

A NPAS4-NuA4 complex couples synaptic activity to DNA repair.

Pollina EA, Gilliam DT, Landau AT, Lin C, Pajarillo N, Davis CP, Harmin DA, Yap EL, Vogel IR, Griffith EC, Nagy MA, Ling E, Duffy EE, Sabatini BL, Weitz CJ, Greenberg ME
Nature 2023 Feb;614(7949):732-741

---

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.

Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138

---

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis.

Akbar H, Cao J, Wang D, Yuan X, Zhang M, Muthusamy S, Song X, Liu X, Aikhionbare F, Yao X, Gao X, Liu X
Journal of molecular cell biology 2022 Dec 26;14(8)

---

Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival.

Zhang X, Bustos MA, Shoji Y, Ramos RI, Iida Y, Gentry R, Takeshima TL, Hoon DSB
Cancers 2021 Sep 18;13(18)

---

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.

Tang Y, Wang L, Yi T, Xu J, Wang J, Qin JJ, Chen Q, Yip KM, Pan Y, Hong P, Lu Y, Shen HM, Chen HB
Acta pharmaceutica Sinica. B 2021 Dec;11(12):3966-3982

---

DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation.

Hishikawa A, Hayashi K, Kubo A, Miyashita K, Hashiguchi A, Kinouchi K, Yoshimoto N, Nakamichi R, Akashio R, Sugita E, Azegami T, Monkawa T, Suematsu M, Itoh H
iScience 2021 Dec 17;24(12):103436

---

Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility.

Cheng YM, Peng Z, Chen HY, Pan TT, Hu XN, Wang F, Luo T
Human reproduction (Oxford, England) 2020 Mar 27;35(3):494-503

---

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.

You Z, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang Y, Zhang H, Peng C, Zhou T, Tang C, Liu W
Nature communications 2019 Dec 19;10(1):5792

---

Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.

Wang J, Liu H, Gao L, Liu X
Frontiers in pediatrics 2018;6:109

---

Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.

Zhang Y, Ji G, Han S, Shao Z, Lu Z, Huo L, Zhang J, Yang R, Feng Q, Shen H, Wang H, Li X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(2):612-628

---

The transcriptional coactivator TAZ regulates reciprocal differentiation of T(H)17 cells and T(reg) cells.

Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL, Xiao N, Lu L, Han J, Zhou D, Chen L
Nature immunology 2017 Jul;18(7):800-812

---

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Barral S, Morozumi Y, Tanaka H, Montellier E, Govin J, de Dieuleveult M, Charbonnier G, Couté Y, Puthier D, Buchou T, Boussouar F, Urahama T, Fenaille F, Curtet S, Héry P, Fernandez-Nunez N, Shiota H, Gérard M, Rousseaux S, Kurumizaka H, Khochbin S
Molecular cell 2017 Apr 6;66(1):89-101.e8

---

MDR1 mediated chemoresistance: BMI1 and TIP60 in action.

Banerjee Mustafi S, Chakraborty PK, Naz S, Dwivedi SK, Street M, Basak R, Yang D, Ding K, Mukherjee P, Bhattacharya R
Biochimica et biophysica acta 2016 Aug;1859(8):983-93

---

Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).

Yu H, Diao H, Wang C, Lin Y, Yu F, Lu H, Xu W, Li Z, Shi H, Zhao S, Zhou Y, Zhang Y
Molecular & cellular proteomics : MCP 2015 Apr;14(4):1009-23

---

ANP32E is a histone chaperone that removes H2A.Z from chromatin.

Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A
Nature 2014 Jan 30;505(7485):648-53

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

PC-3 cells were subjected to SDS PAGE followed by western blot with 10827-1-AP(KAT5 antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The KAT5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KAT5. This antibody recognizes human,mouse,rat antigen. The KAT5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10827-1-AP.pdf

Show more