Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
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- Product number
- ABIN1673410 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to a sequence at the N-terminal of human NPM1, identical to the related rat and mouse sequences.Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- N-Term
- Isotype
- IgG
- Vial size
- 100 μg
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.
- Handling
- Avoid repeated freezing and thawing.
Submitted references The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.
Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.
Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC, Medical Research Council Adult Leukaemia Working Party
Blood 2008 Mar 1;111(5):2776-84
Blood 2008 Mar 1;111(5):2776-84
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.
Zhang Q, Wang HY, Liu X, Wasik MA
Nature medicine 2007 Nov;13(11):1341-8
Nature medicine 2007 Nov;13(11):1341-8
Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.
Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK
Biochemistry 1989 Feb 7;28(3):1033-9
Biochemistry 1989 Feb 7;28(3):1033-9
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