Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11-4033 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Nucleophosmin Antibody
- Antibody type
- Polyclonal
- Description
- Nucleophosmin (NPM1) is a multifunctional, ubiquitously expressed nucleolar phoshoprotein which shuttles continuously between the nucleus and cytoplasm and plays an important role in cell proliferation and apoptosis. This protein exerts its functions through the interaction with a multiplicity of biological partners, specifically recognizes DNA G-quadruplexes through its C-terminal region. It is mainly localized in the nucleolus and has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. Mutations at exon 12 of NPM1 gene is a hallmark of cytogenetically normal acute myeloid leukemia.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant Nucleo
phosmin protein (amino acids 18-236
) was used as the immunogen for thi
s antibody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of Nucleophosmin. Anti- Nucleophosmin antibody (11-4033) was used at 2 µg/ml on Hela lysate.
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of Nucleophosmin. Anti-Nucleophosmin antibody (11-4033) in human Tonsil tissue at 5 µg/ml.