orb2636905

antibody from Biorbyt
Targeting: MXI1 bHLHc11, MAD2, MXD2, MXI
Provider product page for orb2636905
Western blot
Immunocytochemistry
Flow cytometry

Antibody data

Product number
orb2636905 - Provider product page
Provider
Biorbyt
Product name
MXI1 Antibody / BHLHC11
Antibody type
Monoclonal
Description
It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
PCRP-MXI1-1A3
Vial size
20 ug
Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
MXI1 protein structure - orb2636905 shown in red.