Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 15123-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15123-1-AP, RRID:AB_2153579
- Product name
- NNMT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NNMT antibody (Cat. #15123-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.
Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis.
Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function.
Structure-Activity Relationship Studies on Cell-Potent Nicotinamide N-Methyltransferase Bisubstrate Inhibitors.
Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition.
Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease.
Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells.
Wang J, Zhang M, You X, Xu Y, Zhang C, Li Y, Yang C, Wang Q
Frontiers in pharmacology 2024;15:1415310
Frontiers in pharmacology 2024;15:1415310
Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis.
Yan J, Zhou L, Liu M, Zhu H, Zhang X, Cai E, Xu X, Chen T, Cheng H, Liu J, Wang S, Dai L, Chang X, Tang F
Cell reports 2024 Mar 26;43(3):113716
Cell reports 2024 Mar 26;43(3):113716
Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Meng Y, Iyamu ID, Ahmed NAM, Huang R
ACS chemical biology 2024 Jan 19;19(1):89-100
ACS chemical biology 2024 Jan 19;19(1):89-100
Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function.
Zhang Q, Li Z, Li Q, Trammell SA, Schmidt MS, Pires KM, Cai J, Zhang Y, Kenny H, Boudina S, Brenner C, Abel ED
The EMBO journal 2024 Feb;43(3):362-390
The EMBO journal 2024 Feb;43(3):362-390
Structure-Activity Relationship Studies on Cell-Potent Nicotinamide N-Methyltransferase Bisubstrate Inhibitors.
Iyamu ID, Zhao T, Huang R
Journal of medicinal chemistry 2023 Aug 10;66(15):10510-10527
Journal of medicinal chemistry 2023 Aug 10;66(15):10510-10527
Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
Zhao H, Li R, Chen Y, Yang X, Shang Z
Oncogene 2023 Apr;42(15):1166-1180
Oncogene 2023 Apr;42(15):1166-1180
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Yang C, Wang T, Zhu S, Zong Z, Luo C, Zhao Y, Liu J, Li T, Liu X, Liu C, Deng H
ACS omega 2022 Oct 25;7(42):37509-37519
ACS omega 2022 Oct 25;7(42):37509-37519
NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition.
Wu C, Liu Y, Liu W, Zou T, Lu S, Zhu C, He L, Chen J, Fang L, Zou L, Wang P, Fan L, Wang H, You H, Chen J, Fang JY, Jiang C, Shi Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov 16;10(1):e2202642
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov 16;10(1):e2202642
Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
Xu W, Hou L, Li P, Li L
Bioengineered 2022 May;13(5):12421-12434
Bioengineered 2022 May;13(5):12421-12434
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease.
Takahashi R, Kanda T, Komatsu M, Itoh T, Minakuchi H, Urai H, Kuroita T, Shigaki S, Tsukamoto T, Higuchi N, Ikeda M, Yamanaka R, Yoshimura N, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Wakino S, Itoh H
Scientific reports 2022 Apr 16;12(1):6398
Scientific reports 2022 Apr 16;12(1):6398
Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
Ehebauer F, Ghavampour S, Kraus D
Life sciences 2020 May 1;248:117474
Life sciences 2020 May 1;248:117474
Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.
Li J, You S, Zhang S, Hu Q, Wang F, Chi X, Zhao W, Xie C, Zhang C, Yu Y, Liu J, Zhao Y, Liu P, Zhang Y, Wei X, Li Q, Wang X, Yin Z
Molecular oncology 2019 Sep;13(9):1993-2009
Molecular oncology 2019 Sep;13(9):1993-2009
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y, Guan F
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH
Molecular metabolism 2019 May;23:1-13
Molecular metabolism 2019 May;23:1-13
Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells.
Geng F, Liu J, Guo Y, Li C, Wang H, Wang H, Zhao H, Pan Y
Frontiers in cellular and infection microbiology 2017;7:57
Frontiers in cellular and infection microbiology 2017;7:57
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The NNMT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NNMT. This antibody recognizes human, mouse, rat antigen. The NNMT antibody has been validated for the following applications: ELISA, WB analysis.