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- Antibody Data
- Antigen structure
- References [113]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 12922-3-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12922-3-AP, RRID:AB_2118516
- Product name
- HDAC2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC2 antibody (Cat. #12922-3-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs-STAT3 Pathway.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.
Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury.
Polygalacin D Prevents Breast Cancer Progression through Proteasome-Mediated Degradation of HDAC1 and HDAC2.
HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction.
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.
Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma.
The novel selective HDAC1 inhibitor ZJH-1 exhibits potent antitumor activity in castration-resistant prostate cancer, potentially involving HSP90AA1.
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.
The miR-146a-associated HDAC2 regulation of PI3K is involved in pancreatitis in vitro.
IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor Complexes.
The Epigenetic Reader PHF23 Is Required for Embryonic Neurogenesis.
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis.
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function.
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy.
Prognostic and immunotherapeutic response prediction in hepatocellular carcinoma: role of non-histone acetylation/deacetylation scoring.
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan.
HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3.
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Isoliquiritigenin ameliorates abnormal oligodendrocyte development and behavior disorders induced by white matter injury.
Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis.
Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin.
Role of m6A Methylation Regulators in the Diagnosis and Subtype Classification of COPD Based on the GEO Database.
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac.
PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway.
Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3-Regulated Histone Deacetylation and Transcription.
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation.
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation.
ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.
Sphingolipid metabolism controls mammalian heart regeneration.
Intratumor microbiome-derived butyrate promotes lung cancer metastasis.
AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway.
Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.
SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation.
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Amino acid editing of NFE2L1 by PNGase causes abnormal mobility on SDS-PAGE.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
ATP5O Hypo-crotonylation Caused by HDAC2 Hyper-Phosphorylation Is a Primary Detrimental Factor for Downregulated Phospholipid Metabolism under Chronic Stress.
Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
Aging-related features predict prognosis and immunotherapy efficacy in hepatocellular carcinoma.
Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.
Inhibitory Effect of Essential Oil From Fructus of Alpinia zerumbet on Endothelial-to-Mesenchymal Transformation Induced by TGF-β1 and Downregulation of KLF4.
Bisphenol-A exposure leads to neurotoxicity through upregulating the expression of histone deacetylase 2 in vivo and in vitro.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Multi-omics analyses reveal the mechanisms of Arsenic-induced male reproductive toxicity in mice.
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A/ARID1A axis.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells.
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression.
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Quantitative analysis of global protein stability rates in tissues.
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.
LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression.
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
Purification and enzymatic assay of class I histone deacetylase enzymes.
Gestational stress induced differential expression of HDAC2 in male rat offspring hippocampus during development.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
MicroRNA‑223 promotes osteoblast differentiation of MC3T3‑E1 cells by targeting histone deacetylase 2.
Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
LncRNA HOXA-AS2 positively regulates osteogenesis of mesenchymal stem cells through inactivating NF-κB signalling.
Clinical significance of enhancer of zeste homolog 2 and histone deacetylases 1 and 2 expression in peripheral T-cell lymphoma.
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
BRG1, the ATPase subunit of SWI/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cells.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
Dai B, Wang S, Peng X, Wu K, Wu M, Lu Z, Zhong H, Qian X, Tan S, Yang H, Sun T, Wang J, Zhang J, Jiang H, Tong Y, Chen T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e02791
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e02791
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.
Punga T, Larsson M, Mujica E, Rabelo Melo F, Metzendorf C, Zhang H, Wang D, den Hoed M, Andersson L, Parrine D
Scientific reports 2026 Apr 30;16(1)
Scientific reports 2026 Apr 30;16(1)
Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury.
Li X, Yao X, Guo C, Liu Y, Liu M, Li J, Zhang M, Feng Y, Ren C, Yao R
Stem cell reports 2026 Apr 14;21(4):102853
Stem cell reports 2026 Apr 14;21(4):102853
Polygalacin D Prevents Breast Cancer Progression through Proteasome-Mediated Degradation of HDAC1 and HDAC2.
Zhang X, Wang F, Dai Y, Gao Z, He J
Biological & pharmaceutical bulletin 2025;48(12):1897-1905
Biological & pharmaceutical bulletin 2025;48(12):1897-1905
HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction.
Wen Y, Li M, Hao Y, Peng J, Wei X, Zhang Z, Liu B, Wang Y, Peng T, Ma Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156976
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156976
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818
Journal of hazardous materials 2025 Sep 5;495:138818
Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.
Chen S, Xie Y, Liang Z, Liu J, Wang J, Mao Y, Xing F, Wei X, Wang Z, Yang J, Yuan J
Biomedical journal 2025 Oct;48(5):100826
Biomedical journal 2025 Oct;48(5):100826
Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma.
Yao J, Li M, Jiang Y, Yao N, Liu Y, Lv L, Li Y, Huang J, Zha J, Xu B
Cell death discovery 2025 Oct 6;11(1):445
Cell death discovery 2025 Oct 6;11(1):445
The novel selective HDAC1 inhibitor ZJH-1 exhibits potent antitumor activity in castration-resistant prostate cancer, potentially involving HSP90AA1.
Bao Y, Li J, Zhang A, Ni Y, Bi M, Chen J
Chemico-biological interactions 2025 Nov 1;421:111777
Chemico-biological interactions 2025 Nov 1;421:111777
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Sun Y, Wang J, Ding W, Qin Q, Wang R, Yu R, Yan J, Hou R, Liu G, Cai X, Qu Z, Zhang W, Yu J, Xing C, Zhuang C
Redox biology 2025 May;82:103620
Redox biology 2025 May;82:103620
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
Li C, Liu S, Gao J, Xu Y, Peng Q, Weng D, Wang D, Yang W, Yi P, Lin Z, Chen J
Gene 2025 May 20;950:149369
Gene 2025 May 20;950:149369
IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.
Ghosh A, Britto J, Chandran B, Roy A
Journal of virology 2025 Mar 18;99(3):e0154924
Journal of virology 2025 Mar 18;99(3):e0154924
The miR-146a-associated HDAC2 regulation of PI3K is involved in pancreatitis in vitro.
Zhong DW, Zeng XT, Chen WH, Huang XY, Liu JX, Liao YH
Biochemistry and biophysics reports 2025 Jun;42:102057
Biochemistry and biophysics reports 2025 Jun;42:102057
IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor Complexes.
Ghosh A, Chandran B, Roy A
Viruses 2025 Jun 28;17(7)
Viruses 2025 Jun 28;17(7)
The Epigenetic Reader PHF23 Is Required for Embryonic Neurogenesis.
Wen Y, He P, Huang Z, Ding C, Zhang T, Zhang L, Zheng J, Chen M, Chen C, Liu Y, Wang Y, Zhang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Jun 25;45(26)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Jun 25;45(26)
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
Ye Y, Huang L, Wang K, Sun Y, Zhou Z, Deng T, Liu Y, Wang R, Wu R, Yao C
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis.
Xu Y, Meng W, Dai Y, Xu L, Ding N, Zhang J, Zhuang X
Cell death discovery 2025 Feb 8;11(1):54
Cell death discovery 2025 Feb 8;11(1):54
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Yang HX, Wang BX, Dong XL, Sun J, Miao ZL, Pan LL
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function.
Yuan H, Bao Y, Li L, Luan Y, Li F
Archives of gerontology and geriatrics 2025 Dec;139:106020
Archives of gerontology and geriatrics 2025 Dec;139:106020
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy.
Sun S, Lai C, Huang C, Ren X, Zhang T, Zou J, Tong Y, Zhou Q, Lu J, Shen Z, Chen W, Wang R, Rabrenovic N, Wang X, Ma B, Qian J, Fu G, Shang M
Nature communications 2025 Dec 15;17(1):756
Nature communications 2025 Dec 15;17(1):756
Prognostic and immunotherapeutic response prediction in hepatocellular carcinoma: role of non-histone acetylation/deacetylation scoring.
Li J, Huang S, Yuan F, Yang X, Xie Q
Discover oncology 2025 Aug 7;16(1):1488
Discover oncology 2025 Aug 7;16(1):1488
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan.
Wang M, Li H, Han C, Chen Y, He L, Xie M, Lal H, Fast VG, Moellering DR, Zhang J, Lu R, Young M, Zhou Y
American journal of physiology. Heart and circulatory physiology 2025 Aug 1;329(2):H315-H329
American journal of physiology. Heart and circulatory physiology 2025 Aug 1;329(2):H315-H329
HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3.
Wu N, Sun Q, Yang L, Sun H, Zhou Z, Hu Q, Li C, Wang D, Zhang L, Hu Y, Cong X
International journal of biological macromolecules 2025 Apr;300:140310
International journal of biological macromolecules 2025 Apr;300:140310
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Gou P, Fang C, Xu M, Zhang D, Wu X, Zhang L, Li X, Li M, Gan L, Luo J, Cui H, Liang P
Cell death discovery 2025 Apr 14;11(1):172
Cell death discovery 2025 Apr 14;11(1):172
Isoliquiritigenin ameliorates abnormal oligodendrocyte development and behavior disorders induced by white matter injury.
Wu D, Zhou W, Du J, Zhao T, Li N, Peng F, Li A, Zhang X, Zhang M, Hao A
Frontiers in pharmacology 2024;15:1473019
Frontiers in pharmacology 2024;15:1473019
Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis.
Ma Y, Wei X, Peng J, Wei F, Wen Y, Liu M, Song B, Wang Y, Zhang Y, Peng T
Frontiers in pharmacology 2024;15:1414675
Frontiers in pharmacology 2024;15:1414675
Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin.
Fu Q, Song Y, Ling Z, Liu J, Kong Q, Hao X, Xu T, Zhang Q, Liu Y
Diabetes 2024 Sep 1;73(9):1513-1526
Diabetes 2024 Sep 1;73(9):1513-1526
Role of m6A Methylation Regulators in the Diagnosis and Subtype Classification of COPD Based on the GEO Database.
Zhang P, Gao N, Li X, Zheng X, Kong D, Wu J
Journal of cellular and molecular medicine 2024 Nov;28(22):e70226
Journal of cellular and molecular medicine 2024 Nov;28(22):e70226
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.
Zhang Z, Tang Y, Wang Y, Xu J, Yang X, Liu M, Mazzone M, Niu N, Sun Y, Tang Y, Xue J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2402244
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2402244
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Li J, Zhu X, Ye S, Dong Q, Hou J, Liu J, She W
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac.
Zhang X, Guo J, Xu H, Ding S, Liu L, Chen Z, Yang J, Liu Y, Hao H, Huang F, Qiu J, Guan W, Sun Y, Liu H
Journal of virology 2024 Mar 19;98(3):e0169523
Journal of virology 2024 Mar 19;98(3):e0169523
PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification.
Yang J, Xiao Y, Zhao N, Pei G, Sun Y, Sun X, Yu K, Miao C, Liu R, Lv J, Chu H, Zhou L, Wang B, Yao Z, Wang Q
Acta pharmaceutica Sinica. B 2024 Jul;14(7):3049-3067
Acta pharmaceutica Sinica. B 2024 Jul;14(7):3049-3067
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.
Hui Y, Kuang L, Zhong Y, Tang Y, Xu Z, Zheng T
iScience 2024 Jan 19;27(1):108689
iScience 2024 Jan 19;27(1):108689
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway.
Pei L, Zhao F, Zhang Y
Apoptosis : an international journal on programmed cell death 2024 Feb;29(1-2):210-228
Apoptosis : an international journal on programmed cell death 2024 Feb;29(1-2):210-228
Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3-Regulated Histone Deacetylation and Transcription.
Li CH, Liang SB, Huang QW, Zhou ZZ, Ding Z, Long N, Wi KC, Li L, Jiang XP, Fan YJ, Xu YZ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2307804
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2307804
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation.
Chen Y, He W, Qiu J, Luo Y, Jiang C, Zhao F, Wei H, Meng J, Long T, Zhang X, Yang L, Xu Q, Wang J, Zhang C
Cellular & molecular biology letters 2024 Aug 28;29(1):114
Cellular & molecular biology letters 2024 Aug 28;29(1):114
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation.
Li H, Liuha X, Chen R, Xiao Y, Xu W, Zhou Y, Bai L, Zhang J, Zhao Y, Zhao Y, Wang L, Qin F, Chen Y, Han S, Wei Q, Li S, Zhang D, Bu Q, Wang X, Jiang L, Dai Y, Zhang N, Kuang W, Qin M, Wang H, Tian J, Zhao Y, Cen X
Cell reports 2024 Aug 27;43(8):114529
Cell reports 2024 Aug 27;43(8):114529
ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.
Zhou M, Yang T, Yuan M, Li X, Deng J, Wu S, Zhong Z, Lin Y, Zhang W, Xia B, Wu Y, Wang L, Chen T, Liu R, Pan T, Ma X, Li L, Liu B, Zhang H
Journal of virology 2024 Aug 20;98(8):e0003524
Journal of virology 2024 Aug 20;98(8):e0003524
Sphingolipid metabolism controls mammalian heart regeneration.
Ji X, Chen Z, Wang Q, Li B, Wei Y, Li Y, Lin J, Cheng W, Guo Y, Wu S, Mao L, Xiang Y, Lan T, Gu S, Wei M, Zhang JZ, Jiang L, Wang J, Xu J, Cao N
Cell metabolism 2024 Apr 2;36(4):839-856.e8
Cell metabolism 2024 Apr 2;36(4):839-856.e8
Intratumor microbiome-derived butyrate promotes lung cancer metastasis.
Ma Y, Chen H, Li H, Zheng M, Zuo X, Wang W, Wang S, Lu Y, Wang J, Li Y, Wang J, Qiu M
Cell reports. Medicine 2024 Apr 16;5(4):101488
Cell reports. Medicine 2024 Apr 16;5(4):101488
AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway.
Deng L, Bao W, Zhang B, Zhang S, Chen Z, Zhu X, He B, Wu L, Chen X, Deng T, Chen B, Yu Z, Wang Y, Chen G
Cell death & disease 2023 Sep 5;14(9):590
Cell death & disease 2023 Sep 5;14(9):590
Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.
Dai Y, Wei T, Huang Y, Bei Y, Lin H, Shen Z, Yu L, Yang M, Xu H, He W, Lin Z, Dai H
Cellular and molecular life sciences : CMLS 2023 Sep 10;80(10):289
Cellular and molecular life sciences : CMLS 2023 Sep 10;80(10):289
SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.
Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W
The Journal of clinical investigation 2023 Sep 1;133(17)
The Journal of clinical investigation 2023 Sep 1;133(17)
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
Gu X, Shen N, Huang C, Wang HL
Toxicology 2023 Nov;499:153639
Toxicology 2023 Nov;499:153639
Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.
Zhang Z, Wang Y, Liang Z, Meng Z, Zhang X, Ma G, Chen Y, Zhang M, Su Y, Li Z, Liang Y, Niu H
iScience 2023 Nov 17;26(11):108142
iScience 2023 Nov 17;26(11):108142
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation.
Wang S, Qiao C, Li J, Liu S, Li P
Carcinogenesis 2023 May 27;44(3):209-220
Carcinogenesis 2023 May 27;44(3):209-220
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152
Journal of affective disorders 2023 Mar 1;324:143-152
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Li L, Wang X, Hu K, Liu X, Qiu L, Bai C, Cui Y, Wang B, Wang Z, Wang H, Cheng R, Hua J, Hai L, Wang M, Liu M, Song Z, Xiao C, Li B
Oncogene 2023 Jun;42(27):2166-2182
Oncogene 2023 Jun;42(27):2166-2182
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
Zhang J, Zhang Y, Feng D, Zhou H, Gui Z, Zheng M, Hang Z, Gu M, Tan R
Cell death discovery 2023 Jul 28;9(1):271
Cell death discovery 2023 Jul 28;9(1):271
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
Amino acid editing of NFE2L1 by PNGase causes abnormal mobility on SDS-PAGE.
Tachida Y, Hirayama H, Suzuki T
Biochimica et biophysica acta. General subjects 2023 Dec;1867(12):130494
Biochimica et biophysica acta. General subjects 2023 Dec;1867(12):130494
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC
iScience 2023 Apr 21;26(4):106350
iScience 2023 Apr 21;26(4):106350
ATP5O Hypo-crotonylation Caused by HDAC2 Hyper-Phosphorylation Is a Primary Detrimental Factor for Downregulated Phospholipid Metabolism under Chronic Stress.
Chen LJ, Tu ZY, Wang Y, He YH, Wang X, Tao SZ, Xu YY, Li CR, Wang RL, Yang ZX, Sun J, Ma X, Zhang D
Research (Washington, D.C.) 2022;2022:9834963
Research (Washington, D.C.) 2022;2022:9834963
Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
Zhu GQ, Wang Y, Wang B, Liu WR, Dong SS, Chen EB, Cai JL, Wan JL, Du JX, Song LN, Chen SP, Yu L, Zhou ZJ, Wang Z, Zhou J, Shi YH, Fan J, Dai Z
Cellular and molecular gastroenterology and hepatology 2022;13(5):1413-1447
Cellular and molecular gastroenterology and hepatology 2022;13(5):1413-1447
Aging-related features predict prognosis and immunotherapy efficacy in hepatocellular carcinoma.
Hong T, Su W, Pan Y, Tian C, Lei G
Frontiers in immunology 2022;13:951459
Frontiers in immunology 2022;13:951459
Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.
Liu G, Wang Q, Deng L, Huang X, Yang G, Cheng Q, Guo T, Guo L, Niu C, Yang X, Dong J, Zhang J
Theranostics 2022;12(5):2248-2265
Theranostics 2022;12(5):2248-2265
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
Yuan S, Huang T, Bao Z, Wang S, Wu X, Liu J, Liu H, Chen ZJ
Genome biology 2022 Sep 6;23(1):187
Genome biology 2022 Sep 6;23(1):187
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Zhao Y, Guo Y, Sun M, Hussion S, Zheng Y, Huang H, Huo X, Zhao Y, Zhang F, Han Y, Ning Q, Xu P, Sun J, Lu S
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.
Teafatiller T, Subramanian S, Marquez FE, Kitazawa M, Subramanian VS
Life sciences 2022 Nov 1;308:120944
Life sciences 2022 Nov 1;308:120944
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.
Chen T, Gu K, Lin R, Liu Y, Shan Y
Bioengineered 2022 May;13(5):13703-13717
Bioengineered 2022 May;13(5):13703-13717
Inhibitory Effect of Essential Oil From Fructus of Alpinia zerumbet on Endothelial-to-Mesenchymal Transformation Induced by TGF-β1 and Downregulation of KLF4.
Zhang Y, Zhao S, Tu M, He L, Xu Y, Gan S, Shen X
Journal of cardiovascular pharmacology 2022 Jul 1;80(1):82-94
Journal of cardiovascular pharmacology 2022 Jul 1;80(1):82-94
Bisphenol-A exposure leads to neurotoxicity through upregulating the expression of histone deacetylase 2 in vivo and in vitro.
Bi N, Gu X, Fan A, Li D, Wang M, Zhou R, Sun QC, Wang HL
Toxicology 2022 Jan 15;465:153052
Toxicology 2022 Jan 15;465:153052
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Sun X, Shu Y, Ye G, Wu C, Xu M, Gao R, Huang D, Zhang J
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Multi-omics analyses reveal the mechanisms of Arsenic-induced male reproductive toxicity in mice.
Peng Z, Yang Q, Yeerken R, Chen J, Liu X, Li X
Journal of hazardous materials 2022 Feb 15;424(Pt C):127548
Journal of hazardous materials 2022 Feb 15;424(Pt C):127548
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Zheng Z, Zhang S, Chen J, Zou M, Yang Y, Lu W, Ren S, Wang X, Dong W, Zhang Z, Wang L, Guan M, Cheing GLY, Xue Y, Jia Y
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.
Li W, Ye K, Li X, Liu X, Peng M, Chen F, Xiong W, Wang Y, Zhu L
Journal of experimental & clinical cancer research : CR 2022 Aug 17;41(1):250
Journal of experimental & clinical cancer research : CR 2022 Aug 17;41(1):250
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP
Cell death discovery 2021 Sep 27;7(1):265
Cell death discovery 2021 Sep 27;7(1):265
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J
Experimental cell research 2021 Sep 1;406(1):112722
Experimental cell research 2021 Sep 1;406(1):112722
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Moti BS, Oz E, Olga A, Bella G, Shifra S, Eilam P
Cerebral cortex (New York, N.Y. : 1991) 2021 Oct 22;31(12):5487-5496
Cerebral cortex (New York, N.Y. : 1991) 2021 Oct 22;31(12):5487-5496
Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A/ARID1A axis.
Mai H, Liao Y, Luo S, Wei K, Yang F, Shi H
Journal of cellular and molecular medicine 2021 Nov;25(21):9972-9982
Journal of cellular and molecular medicine 2021 Nov;25(21):9972-9982
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, Peng C, Zhou T, Sun Q, Wan W, Liu W
Autophagy 2021 May;17(5):1157-1169
Autophagy 2021 May;17(5):1157-1169
KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells.
Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y, Jin J
Biomolecules & therapeutics 2021 Mar 1;29(2):184-194
Biomolecules & therapeutics 2021 Mar 1;29(2):184-194
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)
The Journal of experimental medicine 2021 Dec 6;218(12)
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression.
Li X, Yuan B, Lu M, Wang Y, Ding N, Liu C, Gao M, Yao Z, Zhang S, Zhao Y, Xie L, Chen Z
Nature communications 2021 Dec 10;12(1):7213
Nature communications 2021 Dec 10;12(1):7213
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Ma L, Qi L, Li S, Yin Q, Liu J, Wang J, She C, Li P, Liu Q, Wang X, Li W
Thoracic cancer 2020 Sep;11(9):2493-2505
Thoracic cancer 2020 Sep;11(9):2493-2505
Quantitative analysis of global protein stability rates in tissues.
McClatchy DB, Martínez-Bartolomé S, Gao Y, Lavallée-Adam M, Yates JR 3rd
Scientific reports 2020 Sep 29;10(1):15983
Scientific reports 2020 Sep 29;10(1):15983
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
Shu Q, Shao Y, Liu R, Hu Y, Peng Z, Tian J
Molecular medicine reports 2020 Oct;22(4):3453-3463
Molecular medicine reports 2020 Oct;22(4):3453-3463
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.
Buck JM, O'Neill HC, Stitzel JA
Epigenetics & chromatin 2020 Mar 5;13(1):13
Epigenetics & chromatin 2020 Mar 5;13(1):13
LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression.
Wang Z, Yu W, Qiang Y, Xu L, Ma F, Ding P, Shi L, Chang W, Mei Y, Ma X
Molecular therapy oncolytics 2020 Jun 26;17:547-561
Molecular therapy oncolytics 2020 Jun 26;17:547-561
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
Zhang Y, Cao X, Li P, Fan Y, Zhang L, Ma X, Sun R, Liu Y, Li W
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
Zhao H, Wang Y, Yang C, Zhou J, Wang L, Yi K, Li Y, Wang Q, Shi J, Kang C, Zeng L
Clinical and translational medicine 2020 Jan 28;9(1):10
Clinical and translational medicine 2020 Jan 28;9(1):10
Purification and enzymatic assay of class I histone deacetylase enzymes.
Adams MK, Banks CAS, Miah S, Killer M, Washburn MP
Methods in enzymology 2019;626:23-40
Methods in enzymology 2019;626:23-40
Gestational stress induced differential expression of HDAC2 in male rat offspring hippocampus during development.
Liao L, Wang X, Yao X, Zhang B, Zhou L, Huang J
Neuroscience research 2019 Oct;147:9-16
Neuroscience research 2019 Oct;147:9-16
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
MicroRNA‑223 promotes osteoblast differentiation of MC3T3‑E1 cells by targeting histone deacetylase 2.
Chen J, He G, Wang Y, Cai D
International journal of molecular medicine 2019 Mar;43(3):1513-1521
International journal of molecular medicine 2019 Mar;43(3):1513-1521
Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells.
Zhang H, Liu Q, Kong L, Xu S
Life sciences 2019 Mar 15;221:168-177
Life sciences 2019 Mar 15;221:168-177
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
LncRNA HOXA-AS2 positively regulates osteogenesis of mesenchymal stem cells through inactivating NF-κB signalling.
Zhu X, Yu J, Du J, Zhong G, Qiao L, Lin J
Journal of cellular and molecular medicine 2019 Feb;23(2):1325-1332
Journal of cellular and molecular medicine 2019 Feb;23(2):1325-1332
Clinical significance of enhancer of zeste homolog 2 and histone deacetylases 1 and 2 expression in peripheral T-cell lymphoma.
Zhang H, Lv H, Jia X, Hu G, Kong L, Zhang T, Li L, Pan Y, Zhai Q, Meng B, Wang X, Wang H, Wang X
Oncology letters 2019 Aug;18(2):1415-1423
Oncology letters 2019 Aug;18(2):1415-1423
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858
International journal of biological sciences 2018;14(13):1845-1858
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Yan H, Yi S, Zhuang H, Wu L, Wang DW, Jiang J
International journal of molecular medicine 2018 Mar;41(3):1704-1714
International journal of molecular medicine 2018 Mar;41(3):1704-1714
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Xu Q, Liu X, Zhu S, Hu X, Niu H, Zhang X, Zhu D, Nesa EU, Tian K, Yuan H
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.
Wu Y, Xu Y, Huang X, Ye D, Han M, Wang HL
Toxicological sciences : an official journal of the Society of Toxicology 2018 Apr 1;162(2):688-701
Toxicological sciences : an official journal of the Society of Toxicology 2018 Apr 1;162(2):688-701
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Duan H, Zhou K, Zhang Y, Yue P, Wang T, Li Y, Qiu D, Wu J, Hua Y, Wang C
Placenta 2017 Oct;58:105-114
Placenta 2017 Oct;58:105-114
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C
Chinese medical journal 2017 Jun 5;130(11):1352-1360
Chinese medical journal 2017 Jun 5;130(11):1352-1360
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y
Placenta 2017 Jan;49:37-47
Placenta 2017 Jan;49:37-47
Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
Hu XT, Zhu BL, Zhao LG, Wang JW, Liu L, Lai YJ, He L, Deng XJ, Chen GJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1482-1493
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1482-1493
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Cancer biology & therapy 2016 Nov;17(11):1117-1125
USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.
Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, Bai L, Wang W, Chen M, Wang W, Gu L, Lv K, Chen J
Oncogene 2016 Jun 2;35(22):2902-12
Oncogene 2016 Jun 2;35(22):2902-12
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45
International journal of oncology 2015;46(6):2535-45
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
BRG1, the ATPase subunit of SWI/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cells.
Wu S, Ge Y, Huang L, Liu H, Xue Y, Zhao Y
Cell cycle (Georgetown, Tex.) 2014;13(18):2869-78
Cell cycle (Georgetown, Tex.) 2014;13(18):2869-78
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 12922-3-AP(HDAC2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HDAC2 antibody 12922-3-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HDAC2 (IP:12922-3-AP, 3ug; Detection:12922-3-AP 1:1000) with mouse testis tissue lysate 10000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 12922-3-AP(HDAC2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC2. This antibody recognizes human,mouse,rat antigen. The HDAC2 antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP, FC analysis.
