BS4637

antibody from Bioworld Technology, Inc
Targeting: HDAC2 KDAC2, RPD3, YAF1
Provider product page for BS4637

Antibody data

Product number
BS4637 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HDAC2 (phospho S394) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human HDAC2 around the phosphorylation site of Serine 394.
Description
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HDAC2 protein structure - BS4637 shown in red.