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- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Other assay [1]
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- Product number
- MA5-14622 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- HSF1 Monoclonal Antibody (4B4)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-14622 targets Heat Shock Factor 1 in GS, IF, IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
- Antibody clone number
- 4B4
- Concentration
- 0.2 mg/mL
Submitted references New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival.
Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis.
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
A novel function for HSF1-induced mitotic exit failure and genomic instability through direct interaction between HSF1 and Cdc20.
Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity.
Transcription of Satellite III non-coding RNAs is a general stress response in human cells.
Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells.
Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies.
Stress-specific activation and repression of heat shock factors 1 and 2.
Vilaboa N, Boré A, Martin-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R
Nucleic acids research 2017 Jun 2;45(10):5797-5817
Nucleic acids research 2017 Jun 2;45(10):5797-5817
Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis.
Patel P, Julien JP, Kriz J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2015 Jan;12(1):217-33
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2015 Jan;12(1):217-33
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.
Logan IR, McNeill HV, Cook S, Lu X, Meek DW, Fuller-Pace FV, Lunec J, Robson CN
Nucleic acids research 2009 May;37(9):2962-73
Nucleic acids research 2009 May;37(9):2962-73
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
Lee YJ, Kim EH, Lee JS, Jeoung D, Bae S, Kwon SH, Lee YS
Cancer research 2008 Sep 15;68(18):7550-60
Cancer research 2008 Sep 15;68(18):7550-60
A novel function for HSF1-induced mitotic exit failure and genomic instability through direct interaction between HSF1 and Cdc20.
Lee YJ, Lee HJ, Lee JS, Jeoung D, Kang CM, Bae S, Lee SJ, Kwon SH, Kang D, Lee YS
Oncogene 2008 May 8;27(21):2999-3009
Oncogene 2008 May 8;27(21):2999-3009
Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity.
Lu M, Kim HE, Li CR, Kim S, Kwak IJ, Lee YJ, Kim SS, Moon JY, Kim CH, Kim DK, Kang HS, Park JS
Biochemistry 2008 Jun 3;47(22):6007-15
Biochemistry 2008 Jun 3;47(22):6007-15
Transcription of Satellite III non-coding RNAs is a general stress response in human cells.
Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C, Riva S, Biamonti G
Nucleic acids research 2008 Feb;36(2):423-34
Nucleic acids research 2008 Feb;36(2):423-34
Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells.
Valgardsdottir R, Chiodi I, Giordano M, Cobianchi F, Riva S, Biamonti G
Molecular biology of the cell 2005 Jun;16(6):2597-604
Molecular biology of the cell 2005 Jun;16(6):2597-604
Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies.
Denegri M, Moralli D, Rocchi M, Biggiogera M, Raimondi E, Cobianchi F, De Carli L, Riva S, Biamonti G
Molecular biology of the cell 2002 Jun;13(6):2069-79
Molecular biology of the cell 2002 Jun;13(6):2069-79
Stress-specific activation and repression of heat shock factors 1 and 2.
Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI
Molecular and cellular biology 2001 Nov;21(21):7163-71
Molecular and cellular biology 2001 Nov;21(21):7163-71
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of Heat Shock Factor 1 using Heat Shock Factor 1 Monoclonal Antibody (Product # MA5-14622) on LS174T Cells and MAD109 Cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of HSF1 using a monoclonal antibody (Product # MA5-14622).
