Explore
Validate
Learn
Western blot
Immunohistochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [168]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [4]
- Other assay [25]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MA3-910 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- SERCA2 ATPase Monoclonal Antibody (IID8)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA3-910 detects sarcoplasmic or endoplasmic reticulum calcium 2 (SERCA2) ATPase from bovine, canine, human, pig, rabbit and rat tissues. This antibody does not detect frog SERCA2 ATPase (J. Biol. Chem., Feb 2001; 276: 3911 - 3919). MA3-910 detects SERCA2 ATPase and does not discriminate between the two isoforms. MA3-910 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, and immunohistochemistry. By Western blot, this antibody detects an ~110 kDa protein representing SERCA2 ATPase from canine skeletal muscle triad preparations. Immunofluorescence staining of SECRA2 ATPase in rabbit skeletal muscle with MA3-910 results in strong labeling of the entire type I (slow) myofiber consistent with sarcoplasmic reticulum localization. MA3-910 is not recommended for Western blot detection of rat SERCA2. The MA3-910 antigen is purified canine cardiac sarcoplasmic reticulum.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Porcine, Rabbit
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- IID8
- Vial size
- 100 µL
- Concentration
- 1 mg/mL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue.
Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.
Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum.
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells.
Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.
Cardiac, Metabolic and Molecular Profiles of Sedentary Rats in the Initial Moment of Obesity.
A protein interaction mechanism for suppressing the mechanosensitive Piezo channels.
Ryanodine receptors are part of the myospryn complex in cardiac muscle.
Intramyocardial injection of SERCA2a-expressing lentivirus improves myocardial function in doxorubicin-induced heart failure.
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up.
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.
Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA.
Mother's exercise during pregnancy programmes vasomotor function in adult offspring.
Aldosterone blockade reduces mortality without changing cardiac remodeling in spontaneously hypertensive rats.
Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.
Effects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model.
Training-induced acceleration of O(2) uptake on-kinetics precedes muscle mitochondrial biogenesis in humans.
Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels.
Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels.
Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis.
Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans.
Thapsigargin decreases the Na(+)- Ca(2+) exchanger mediated Ca(2+) entry in pig coronary artery smooth muscle.
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase.
The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension.
Influence of taurine on cardiac remodeling induced by tobacco smoke exposure.
Insulin-like growth factor I (IGF-1) deficiency ameliorates sex difference in cardiac contractile function and intracellular Ca(2+) homeostasis.
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Sodium-calcium exchanger and lipid rafts in pig coronary artery smooth muscle.
Reorganization of the nuclear lamina and cytoskeleton in adipogenesis.
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays.
Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality.
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Myocardial contractility is preserved early but reduced late after ovariectomy in young female rats.
Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats.
mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulum.
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Differential redistribution of Ca2+-handling proteins during polarisation of MDCK cells: Effects on Ca2+ signalling.
Caspase-dependent protein phosphatase 2A activation contributes to endotoxin-induced cardiomyocyte contractile dysfunction.
Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.
Superior calcium homeostasis of extraocular muscles.
Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
Calsequestrin and junctin immunoreactivity in hexagonally cross-linked tubular arrays myopathy.
Cardioprotection via modulation of calcium homeostasis by thiopental in hypoxia-reoxygenated neonatal rat cardiomyocytes.
Proximity of Na+ -Ca2+ -exchanger and sarco/endoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle: fluorescence microscopy.
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.
Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.
Na(+)-K(+)-ATPase and Ca(2+) clearance proteins in smooth muscle: a functional unit.
Aerobic exercise training improves Ca2+ handling and redox status of skeletal muscle in mice.
Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells.
Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3.
Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release.
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.
Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells.
Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone.
Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.
Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas.
High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration.
Is Kir6.1 a subunit of mitoK(ATP)?
Proteomic profiling of chronic low-frequency stimulated fast muscle.
Functional and immunocytochemical evidence for the expression and localization of the secretory pathway Ca2+-ATPase isoform 1 (SPCA1) in cerebellum relative to other Ca2+ pumps.
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.
Internalization of caveolae and their relationship with endosomes in cultured human and mouse endothelial cells.
A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.
Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia.
The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.
Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress.
Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation.
Subunit composition and role of Na+,K+-ATPases in ventricular myocytes.
Subunit composition and role of Na+,K+-ATPases in ventricular myocytes.
New insights into skeletal muscle fibre types in the dog with particular focus towards hybrid myosin phenotypes.
Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.
Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function.
Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.
Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation.
Calcium adaptation to sodium pump inhibition in a human megakaryocytic cell line.
A developmental profile of the levels of calcium pumps in chick cerebellum.
Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity.
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.
The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells.
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.
Antisense-mediated Inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cells.
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction.
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.
The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase.
Coordinated expression of myosin heavy chains, metabolic enzymes, and morphological features of porcine skeletal muscle fiber types.
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus.
Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells.
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.
Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.
Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet.
Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema.
Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema.
Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx.
Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity.
Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase.
Increased expression of the nicotinic acetylcholine receptor in stimulated muscle.
Increased expression of the nicotinic acetylcholine receptor in stimulated muscle.
Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.
Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.
Use of continuous-elution gel electrophoresis as a preparative tool for blot overlay analysis.
Supramolecular calsequestrin complex.
Supramolecular calsequestrin complex.
Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation.
Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules.
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node.
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node.
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.
Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.
Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction.
Exercise training attenuates coronary smooth muscle phenotypic modulation and nuclear Ca2+ signaling.
Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.
Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status.
Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status.
Low temperature molecular adaptation of the skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA 1) in the wood frog (Rana sylvatica).
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy.
Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle.
Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
Ca2+ in the dense tubules: a model of platelet Ca2+ load.
Functional characterization of alternatively spliced human SERCA3 transcripts.
Functional characterization of alternatively spliced human SERCA3 transcripts.
Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i waves.
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.
Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes.
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.
Biochemical characterization of ultrastructural localization of a major junctional sarcoplasmic reticulum glycoprotein (triadin).
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase.
Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase.
A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons.
A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons.
Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues.
Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues.
Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.
Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.
Analysis of excitation-contraction-coupling components in chronically stimulated canine skeletal muscle.
Analysis of excitation-contraction-coupling components in chronically stimulated canine skeletal muscle.
Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle.
Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles.
The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules.
A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study.
Shen S, Sewanan LR, Shao S, Halder SS, Stankey P, Li X, Campbell SG
Stem cell reports 2022 Sep 13;17(9):2037-2049
Stem cell reports 2022 Sep 13;17(9):2037-2049
Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.
Zou HY, Guo L, Zhang B, Chen S, Wu XR, Liu XD, Xu XY, Li BY, Chen S, Xu NJ, Sun S
The Journal of clinical investigation 2022 Apr 15;132(8)
The Journal of clinical investigation 2022 Apr 15;132(8)
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.
Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis JJA, Dorsch LM, Blok CS, van den Dungen NAM, Lansu N, Boukens BJ, Efimov IR, Michels M, Verhaar MC, de Weger R, Vink A, van Steenbeek FG, Baas AF, Davis RP, Uh HW, Kuster DWD, Cheng C, Mokry M, van der Velden J, Asselbergs FW, Harakalova M
Clinical epigenetics 2021 Mar 23;13(1):61
Clinical epigenetics 2021 Mar 23;13(1):61
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.
Monti E, Reggiani C, Franchi MV, Toniolo L, Sandri M, Armani A, Zampieri S, Giacomello E, Sarto F, Sirago G, Murgia M, Nogara L, Marcucci L, Ciciliot S, Šimunic B, Pišot R, Narici MV
The Journal of physiology 2021 Jun;599(12):3037-3061
The Journal of physiology 2021 Jun;599(12):3037-3061
Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum.
Furlan S, Campione M, Murgia M, Mosole S, Argenton F, Volpe P, Nori A
Frontiers in neuroanatomy 2020;14:15
Frontiers in neuroanatomy 2020;14:15
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Hu Q, Ahmad AA, Seidel T, Hunter C, Streiff M, Nikolova L, Spitzer KW, Sachse FB
Journal of molecular and cellular cardiology 2020 Feb;139:113-123
Journal of molecular and cellular cardiology 2020 Feb;139:113-123
Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells.
Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O
Scientific reports 2019 Dec 23;9(1):19622
Scientific reports 2019 Dec 23;9(1):19622
Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.
Del Prete D, Suski JM, Oulès B, Debayle D, Gay AS, Lacas-Gervais S, Bussiere R, Bauer C, Pinton P, Paterlini-Bréchot P, Wieckowski MR, Checler F, Chami M
Journal of Alzheimer's disease : JAD 2017;55(4):1549-1570
Journal of Alzheimer's disease : JAD 2017;55(4):1549-1570
Cardiac, Metabolic and Molecular Profiles of Sedentary Rats in the Initial Moment of Obesity.
Jacobsen BB, Leopoldo APL, Cordeiro JP, Campos DHS, Nascimento AFD, Sugizaki MM, Cicogna AC, Padovani CR, Leopoldo AS
Arquivos brasileiros de cardiologia 2017 Nov;109(5):432-439
Arquivos brasileiros de cardiologia 2017 Nov;109(5):432-439
A protein interaction mechanism for suppressing the mechanosensitive Piezo channels.
Zhang T, Chi S, Jiang F, Zhao Q, Xiao B
Nature communications 2017 Nov 27;8(1):1797
Nature communications 2017 Nov 27;8(1):1797
Ryanodine receptors are part of the myospryn complex in cardiac muscle.
Benson MA, Tinsley CL, Waite AJ, Carlisle FA, Sweet SMM, Ehler E, George CH, Lai FA, Martin-Rendon E, Blake DJ
Scientific reports 2017 Jul 24;7(1):6312
Scientific reports 2017 Jul 24;7(1):6312
Intramyocardial injection of SERCA2a-expressing lentivirus improves myocardial function in doxorubicin-induced heart failure.
Mattila M, Koskenvuo J, Söderström M, Eerola K, Savontaus M
The journal of gene medicine 2016 Jul;18(7):124-33
The journal of gene medicine 2016 Jul;18(7):124-33
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
Gustavo Vazquez-Jimenez J, Chavez-Reyes J, Romero-Garcia T, Zarain-Herzberg A, Valdes-Flores J, Manuel Galindo-Rosales J, Rueda A, Guerrero-Hernandez A, Olivares-Reyes JA
Cellular signalling 2016 Jan;28(1):53-9
Cellular signalling 2016 Jan;28(1):53-9
Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad F, Shen W, Vandeput F, Szabo-Fresnais N, Krall J, Degerman E, Goetz F, Klussmann E, Movsesian M, Manganiello V
The Journal of biological chemistry 2015 Mar 13;290(11):6763-76
The Journal of biological chemistry 2015 Mar 13;290(11):6763-76
Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up.
Lenčová-Popelová O, Jirkovský E, Mazurová Y, Lenčo J, Adamcová M, Šimůnek T, Geršl V, Štěrba M
PloS one 2014;9(5):e96055
PloS one 2014;9(5):e96055
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Leanza L, O'Reilly P, Doyle A, Venturini E, Zoratti M, Szegezdi E, Szabo I
Current pharmaceutical design 2014;20(2):189-200
Current pharmaceutical design 2014;20(2):189-200
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.
Stern MD, Maltseva LA, Juhaszova M, Sollott SJ, Lakatta EG, Maltsev VA
The Journal of general physiology 2014 May;143(5):577-604
The Journal of general physiology 2014 May;143(5):577-604
Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA.
Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, Wang Y, Huang X
Cell metabolism 2014 May 6;19(5):861-71
Cell metabolism 2014 May 6;19(5):861-71
Mother's exercise during pregnancy programmes vasomotor function in adult offspring.
Bahls M, Sheldon RD, Taheripour P, Clifford KA, Foust KB, Breslin ED, Marchant-Forde JN, Cabot RA, Harold Laughlin M, Bidwell CA, Newcomer SC
Experimental physiology 2014 Jan;99(1):205-19
Experimental physiology 2014 Jan;99(1):205-19
Aldosterone blockade reduces mortality without changing cardiac remodeling in spontaneously hypertensive rats.
Cezar MD, Damatto RL, Martinez PF, Lima AR, Campos DH, Rosa CM, Guizoni DM, Bonomo C, Cicogna AC, Gimenes R, Pagan LU, Okoshi MP, Okoshi K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013;32(5):1275-87
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013;32(5):1275-87
Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.
Ivashchenko CY, Pipes GC, Lozinskaya IM, Lin Z, Xiaoping X, Needle S, Grygielko ET, Hu E, Toomey JR, Lepore JJ, Willette RN
American journal of physiology. Heart and circulatory physiology 2013 Sep 15;305(6):H913-22
American journal of physiology. Heart and circulatory physiology 2013 Sep 15;305(6):H913-22
Effects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model.
Chou CC, Chang PC, Wen MS, Lee HL, Chu Y, Baba A, Matsuda T, Yeh SJ, Wu D
Pacing and clinical electrophysiology : PACE 2013 May;36(5):596-606
Pacing and clinical electrophysiology : PACE 2013 May;36(5):596-606
Training-induced acceleration of O(2) uptake on-kinetics precedes muscle mitochondrial biogenesis in humans.
Zoladz JA, Grassi B, Majerczak J, Szkutnik Z, Korostyński M, Karasiński J, Kilarski W, Korzeniewski B
Experimental physiology 2013 Apr;98(4):883-98
Experimental physiology 2013 Apr;98(4):883-98
Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG
PloS one 2012;7(5):e37582
PloS one 2012;7(5):e37582
Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels.
Leanza L, Zoratti M, Gulbins E, Szabò I
Current medicinal chemistry 2012;19(31):5394-404
Current medicinal chemistry 2012;19(31):5394-404
Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels.
Leanza L, Zoratti M, Gulbins E, Szabò I
Current medicinal chemistry 2012;19(31):5394-404
Current medicinal chemistry 2012;19(31):5394-404
Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis.
Dremina ES, Sharov VS, Schöneich C
The Biochemical journal 2012 May 15;444(1):127-39
The Biochemical journal 2012 May 15;444(1):127-39
Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans.
Majerczak J, Korostynski M, Nieckarz Z, Szkutnik Z, Duda K, Zoladz JA
Experimental physiology 2012 Mar;97(3):386-99
Experimental physiology 2012 Mar;97(3):386-99
Thapsigargin decreases the Na(+)- Ca(2+) exchanger mediated Ca(2+) entry in pig coronary artery smooth muscle.
Akolkar G, Pande J, Samson SE, Grover AK
Biochimica et biophysica acta 2012 Mar;1818(3):730-7
Biochimica et biophysica acta 2012 Mar;1818(3):730-7
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I
EMBO molecular medicine 2012 Jul;4(7):577-93
EMBO molecular medicine 2012 Jul;4(7):577-93
SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase.
Treves S, Thurnheer R, Mosca B, Vukcevic M, Bergamelli L, Voltan R, Oberhauser V, Ronjat M, Csernoch L, Szentesi P, Zorzato F
The Biochemical journal 2012 Jan 15;441(2):731-41
The Biochemical journal 2012 Jan 15;441(2):731-41
The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension.
Dupont S, Maizel J, Mentaverri R, Chillon JM, Six I, Giummelly P, Brazier M, Choukroun G, Tribouilloy C, Massy ZA, Slama M
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1524-32
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1524-32
Influence of taurine on cardiac remodeling induced by tobacco smoke exposure.
Denipote F, Ardisson LP, Azevedo PS, Minicucci MF, Lima-Leopoldo AP, Chiuso-Minicucci F, Polegato BF, Matsubara BB, Matsubara LS, Novelli E, Paiva SA, Zornoff LA
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(3-4):291-8
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(3-4):291-8
Insulin-like growth factor I (IGF-1) deficiency ameliorates sex difference in cardiac contractile function and intracellular Ca(2+) homeostasis.
Ceylan-Isik AF, Li Q, Ren J
Toxicology letters 2011 Oct 10;206(2):130-8
Toxicology letters 2011 Oct 10;206(2):130-8
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Radwański PB, Poelzing S
Cardiovascular research 2011 Oct 1;92(1):57-66
Cardiovascular research 2011 Oct 1;92(1):57-66
Sodium-calcium exchanger and lipid rafts in pig coronary artery smooth muscle.
Kuszczak I, Samson SE, Pande J, Shen DQ, Grover AK
Biochimica et biophysica acta 2011 Mar;1808(3):589-96
Biochimica et biophysica acta 2011 Mar;1808(3):589-96
Reorganization of the nuclear lamina and cytoskeleton in adipogenesis.
Verstraeten VL, Renes J, Ramaekers FC, Kamps M, Kuijpers HJ, Verheyen F, Wabitsch M, Steijlen PM, van Steensel MA, Broers JL
Histochemistry and cell biology 2011 Mar;135(3):251-61
Histochemistry and cell biology 2011 Mar;135(3):251-61
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Ferreira JC, Moreira JB, Campos JC, Pereira MG, Mattos KC, Coelho MA, Brum PC
Life sciences 2011 Mar 28;88(13-14):578-85
Life sciences 2011 Mar 28;88(13-14):578-85
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
Mostarda C, Moraes-Silva IC, Moreira ED, Medeiros A, Piratello AC, Consolim-Colombo FM, Caldini EG, Brum PC, Krieger EM, Irigoyen MC
Journal of cardiac failure 2011 Jun;17(6):519-25
Journal of cardiac failure 2011 Jun;17(6):519-25
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
Floré V, Claus P, Antoons G, Oosterhoff P, Holemans P, Vos MA, Sipido KR, Willems R
Heart rhythm 2011 Jul;8(7):1050-7
Heart rhythm 2011 Jul;8(7):1050-7
High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays.
Anderson T, Wulfkuhle J, Petricoin E 3rd, Winslow RL
Molecular & cellular proteomics : MCP 2011 Jul;10(7):M111.008037
Molecular & cellular proteomics : MCP 2011 Jul;10(7):M111.008037
Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality.
Jorge L, Rodrigues B, Rosa KT, Malfitano C, Loureiro TC, Medeiros A, Curi R, Brum PC, Lacchini S, Montano N, De Angelis K, Irigoyen MC
European heart journal 2011 Apr;32(7):904-12
European heart journal 2011 Apr;32(7):904-12
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Rodrigues B, Rosa KT, Medeiros A, Schaan BD, Brum PC, De Angelis K, Irigoyen MC
Cardiovascular diabetology 2011 Apr 6;10:26
Cardiovascular diabetology 2011 Apr 6;10:26
Myocardial contractility is preserved early but reduced late after ovariectomy in young female rats.
Paigel AS, Ribeiro RF Jr, Fernandes AA, Targueta GP, Vassallo DV, Stefanon I
Reproductive biology and endocrinology : RB&E 2011 Apr 23;9:54
Reproductive biology and endocrinology : RB&E 2011 Apr 23;9:54
Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino JP, Ghanem A, Tiemann K, Bloch W, Müller-Ehmsen J, Schwinger RH, Brixius K
Physiological research 2010;59(5):679-89
Physiological research 2010;59(5):679-89
Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino JP, Ghanem A, Tiemann K, Bloch W, Müller-Ehmsen J, Schwinger RH, Brixius K
Physiological research 2010;59(5):679-689
Physiological research 2010;59(5):679-689
Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats.
Zulian A, Baryshnikov SG, Linde CI, Hamlyn JM, Ferrari P, Golovina VA
American journal of physiology. Heart and circulatory physiology 2010 Sep;299(3):H624-33
American journal of physiology. Heart and circulatory physiology 2010 Sep;299(3):H624-33
mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulum.
Unsworth H, Raguz S, Edwards HJ, Higgins CF, Yagüe E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Sep;24(9):3370-80
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Sep;24(9):3370-80
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Bueno CR Jr, Ferreira JC, Pereira MG, Bacurau AV, Brum PC
Journal of applied physiology (Bethesda, Md. : 1985) 2010 Sep;109(3):702-9
Journal of applied physiology (Bethesda, Md. : 1985) 2010 Sep;109(3):702-9
Differential redistribution of Ca2+-handling proteins during polarisation of MDCK cells: Effects on Ca2+ signalling.
Collado-Hilly M, Shirvani H, Jaillard D, Mauger JP
Cell calcium 2010 Oct;48(4):215-24
Cell calcium 2010 Oct;48(4):215-24
Caspase-dependent protein phosphatase 2A activation contributes to endotoxin-induced cardiomyocyte contractile dysfunction.
Neviere R, Hassoun SM, Decoster B, Bouazza Y, Montaigne D, Maréchal X, Marciniak C, Marchetti P, Lancel S
Critical care medicine 2010 Oct;38(10):2031-6
Critical care medicine 2010 Oct;38(10):2031-6
Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.
Tong X, Hou X, Jourd'heuil D, Weisbrod RM, Cohen RA
Circulation research 2010 Oct 15;107(8):975-83
Circulation research 2010 Oct 15;107(8):975-83
Superior calcium homeostasis of extraocular muscles.
Zeiger U, Mitchell CH, Khurana TS
Experimental eye research 2010 Nov;91(5):613-22
Experimental eye research 2010 Nov;91(5):613-22
Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, Monteith GR
The Journal of biological chemistry 2010 Nov 26;285(48):37458-66
The Journal of biological chemistry 2010 Nov 26;285(48):37458-66
Calsequestrin and junctin immunoreactivity in hexagonally cross-linked tubular arrays myopathy.
Di Blasi C, Blasevich F, Bellafiore E, Mottarelli E, Gibertini S, Zanotti S, Saredi S, Mantegazza R, Morandi L, Mora M
Neuromuscular disorders : NMD 2010 May;20(5):326-9
Neuromuscular disorders : NMD 2010 May;20(5):326-9
Cardioprotection via modulation of calcium homeostasis by thiopental in hypoxia-reoxygenated neonatal rat cardiomyocytes.
Kim HS, Hwang KC, Park WK
Yonsei medical journal 2010 Mar;51(2):187-96
Yonsei medical journal 2010 Mar;51(2):187-96
Proximity of Na+ -Ca2+ -exchanger and sarco/endoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle: fluorescence microscopy.
Kuszczak I, Kuner R, Samson SE, Grover AK
Molecular and cellular biochemistry 2010 Jun;339(1-2):293-300
Molecular and cellular biochemistry 2010 Jun;339(1-2):293-300
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.
Sassi N, De Marchi U, Fioretti B, Biasutto L, Gulbins E, Franciolini F, Szabò I, Zoratti M
Biochimica et biophysica acta 2010 Jun-Jul;1797(6-7):1260-7
Biochimica et biophysica acta 2010 Jun-Jul;1797(6-7):1260-7
Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.
Juric D, Yao X, Thandapilly S, Louis X, Cantor E, Chaze B, Wojciechowski P, Vasanji Z, Yang T, Wigle J, Netticadan T
Experimental physiology 2010 Aug;95(8):869-79
Experimental physiology 2010 Aug;95(8):869-79
Na(+)-K(+)-ATPase and Ca(2+) clearance proteins in smooth muscle: a functional unit.
Pritchard TJ, Bowman PS, Jefferson A, Tosun M, Lynch RM, Paul RJ
American journal of physiology. Heart and circulatory physiology 2010 Aug;299(2):H548-56
American journal of physiology. Heart and circulatory physiology 2010 Aug;299(2):H548-56
Aerobic exercise training improves Ca2+ handling and redox status of skeletal muscle in mice.
Ferreira JC, Bacurau AV, Bueno CR Jr, Cunha TC, Tanaka LY, Jardim MA, Ramires PR, Brum PC
Experimental biology and medicine (Maywood, N.J.) 2010 Apr;235(4):497-505
Experimental biology and medicine (Maywood, N.J.) 2010 Apr;235(4):497-505
Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells.
De Marchi U, Sassi N, Fioretti B, Catacuzzeno L, Cereghetti GM, Szabò I, Zoratti M
Cell calcium 2009 May;45(5):509-16
Cell calcium 2009 May;45(5):509-16
Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3.
Chandrasekera PC, Kargacin ME, Deans JP, Lytton J
American journal of physiology. Cell physiology 2009 May;296(5):C1105-14
American journal of physiology. Cell physiology 2009 May;296(5):C1105-14
Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release.
Patel JC, Witkovsky P, Avshalumov MV, Rice ME
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 May 20;29(20):6568-79
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 May 20;29(20):6568-79
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.
Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF
Circulation 2009 Mar 10;119(9):1220-30
Circulation 2009 Mar 10;119(9):1220-30
Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells.
Houben F, Willems CH, Declercq IL, Hochstenbach K, Kamps MA, Snoeckx LH, Ramaekers FC, Broers JL
Biochimica et biophysica acta 2009 Feb;1793(2):312-24
Biochimica et biophysica acta 2009 Feb;1793(2):312-24
Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone.
Ketzer LA, Arruda AP, Carvalho DP, de Meis L
American journal of physiology. Heart and circulatory physiology 2009 Aug;297(2):H556-63
American journal of physiology. Heart and circulatory physiology 2009 Aug;297(2):H556-63
Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.
Majerczak J, Karasinski J, Zoladz JA
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2008 Sep;59(3):589-602
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2008 Sep;59(3):589-602
Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas.
Witkovsky P, Gábriel R, Krizaj D
The Journal of comparative neurology 2008 Sep 10;510(2):158-74
The Journal of comparative neurology 2008 Sep 10;510(2):158-74
High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration.
Tong X, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA
Journal of molecular and cellular cardiology 2008 Feb;44(2):361-9
Journal of molecular and cellular cardiology 2008 Feb;44(2):361-9
Is Kir6.1 a subunit of mitoK(ATP)?
Foster DB, Rucker JJ, Marbán E
Biochemical and biophysical research communications 2008 Feb 15;366(3):649-56
Biochemical and biophysical research communications 2008 Feb 15;366(3):649-56
Proteomic profiling of chronic low-frequency stimulated fast muscle.
Donoghue P, Doran P, Wynne K, Pedersen K, Dunn MJ, Ohlendieck K
Proteomics 2007 Sep;7(18):3417-30
Proteomics 2007 Sep;7(18):3417-30
Functional and immunocytochemical evidence for the expression and localization of the secretory pathway Ca2+-ATPase isoform 1 (SPCA1) in cerebellum relative to other Ca2+ pumps.
Sepúlveda MR, Berrocal M, Marcos D, Wuytack F, Mata AM
Journal of neurochemistry 2007 Nov;103(3):1009-18
Journal of neurochemistry 2007 Nov;103(3):1009-18
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.
Armoundas AA, Rose J, Aggarwal R, Stuyvers BD, O'rourke B, Kass DA, Marbán E, Shorofsky SR, Tomaselli GF, William Balke C
American journal of physiology. Heart and circulatory physiology 2007 Mar;292(3):H1607-18
American journal of physiology. Heart and circulatory physiology 2007 Mar;292(3):H1607-18
Internalization of caveolae and their relationship with endosomes in cultured human and mouse endothelial cells.
Aoki T, Hagiwara H, Matsuzaki T, Suzuki T, Takata K
Anatomical science international 2007 Jun;82(2):82-97
Anatomical science international 2007 Jun;82(2):82-97
A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.
Satoh K, Hata M, Takahara S, Tsuzaki H, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T
Brain research 2006 Sep 7;1108(1):19-27
Brain research 2006 Sep 7;1108(1):19-27
Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia.
Nurden P, Debili N, Vainchenker W, Bobe R, Bredoux R, Corvazier E, Combrie R, Fressinaud E, Meyer D, Nurden AT, Enouf J
Blood 2006 Oct 15;108(8):2587-95
Blood 2006 Oct 15;108(8):2587-95
The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.
Okkenhaug H, Weylandt KH, Carmena D, Wells DJ, Higgins CF, Sardini A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Nov;20(13):2390-2
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Nov;20(13):2390-2
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Xu S, Ying J, Jiang B, Guo W, Adachi T, Sharov V, Lazar H, Menzoian J, Knyushko TV, Bigelow D, Schöneich C, Cohen RA
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2220-7
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2220-7
Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.
Kögler H, Schott P, Toischer K, Milting H, Van PN, Kohlhaas M, Grebe C, Kassner A, Domeier E, Teucher N, Seidler T, Knöll R, Maier LS, El-Banayosy A, Körfer R, Hasenfuss G
Circulation 2006 Jun 13;113(23):2724-32
Circulation 2006 Jun 13;113(23):2724-32
Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress.
Chaâbane C, Corvazier E, Bredoux R, Dally S, Raïes A, Villemain A, Dupuy E, Enouf J, Bobe R
Biochemical and biophysical research communications 2006 Jul 14;345(4):1377-85
Biochemical and biophysical research communications 2006 Jul 14;345(4):1377-85
Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation.
Dremina ES, Sharov VS, Schöneich C
Biochemistry 2006 Jan 10;45(1):175-84
Biochemistry 2006 Jan 10;45(1):175-84
Subunit composition and role of Na+,K+-ATPases in ventricular myocytes.
Harada K, Lin H, Endo Y, Fujishiro N, Sakamoto Y, Inoue M
The journal of physiological sciences : JPS 2006 Feb;56(1):113-21
The journal of physiological sciences : JPS 2006 Feb;56(1):113-21
Subunit composition and role of Na+,K+-ATPases in ventricular myocytes.
Harada K, Lin H, Endo Y, Fujishiro N, Sakamoto Y, Inoue M
The journal of physiological sciences : JPS 2006 Feb;56(1):113-21
The journal of physiological sciences : JPS 2006 Feb;56(1):113-21
New insights into skeletal muscle fibre types in the dog with particular focus towards hybrid myosin phenotypes.
Acevedo LM, Rivero JL
Cell and tissue research 2006 Feb;323(2):283-303
Cell and tissue research 2006 Feb;323(2):283-303
Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.
Dolnikov K, Shilkrut M, Zeevi-Levin N, Gerecht-Nir S, Amit M, Danon A, Itskovitz-Eldor J, Binah O
Stem cells (Dayton, Ohio) 2006 Feb;24(2):236-45
Stem cells (Dayton, Ohio) 2006 Feb;24(2):236-45
Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function.
Rodriguez P, Mitton B, Waggoner JR, Kranias EG
The Journal of biological chemistry 2006 Dec 15;281(50):38599-608
The Journal of biological chemistry 2006 Dec 15;281(50):38599-608
Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.
Miyauchi Y, Daiho T, Yamasaki K, Takahashi H, Ishida-Yamamoto A, Danko S, Suzuki H, Iizuka H
The Journal of biological chemistry 2006 Aug 11;281(32):22882-95
The Journal of biological chemistry 2006 Aug 11;281(32):22882-95
Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation.
Donoghue P, Doran P, Dowling P, Ohlendieck K
Biochimica et biophysica acta 2005 Sep 25;1752(2):166-76
Biochimica et biophysica acta 2005 Sep 25;1752(2):166-76
Calcium adaptation to sodium pump inhibition in a human megakaryocytic cell line.
Kimura M, Cao X, Aviv A
American journal of physiology. Cell physiology 2005 Oct;289(4):C891-7
American journal of physiology. Cell physiology 2005 Oct;289(4):C891-7
A developmental profile of the levels of calcium pumps in chick cerebellum.
Sepúlveda MR, Hidalgo-Sánchez M, Mata AM
Journal of neurochemistry 2005 Nov;95(3):673-83
Journal of neurochemistry 2005 Nov;95(3):673-83
Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity.
Deschamps AM, Yarbrough WM, Squires CE, Allen RA, McClister DM, Dowdy KB, McLean JE, Mingoia JT, Sample JA, Mukherjee R, Spinale FG
Circulation 2005 Mar 8;111(9):1166-74
Circulation 2005 Mar 8;111(9):1166-74
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P
The Journal of biological chemistry 2005 Mar 4;280(9):8016-21
The Journal of biological chemistry 2005 Mar 4;280(9):8016-21
Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.
Nguyen T, Rubinstein NA, Vijayasarathy C, Rome LC, Kaiser LR, Shrager JB, Levine S
Journal of applied physiology (Bethesda, Md. : 1985) 2005 Jun;98(6):2004-10
Journal of applied physiology (Bethesda, Md. : 1985) 2005 Jun;98(6):2004-10
The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells.
Brini M, Miuzzo M, Pierobon N, Negro A, Sorgato MC
Molecular biology of the cell 2005 Jun;16(6):2799-808
Molecular biology of the cell 2005 Jun;16(6):2799-808
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.
Vanoevelen J, Dode L, Van Baelen K, Fairclough RJ, Missiaen L, Raeymaekers L, Wuytack F
The Journal of biological chemistry 2005 Jun 17;280(24):22800-8
The Journal of biological chemistry 2005 Jun 17;280(24):22800-8
Antisense-mediated Inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cells.
Lee WJ, Robinson JA, Holman NA, McCall MN, Roberts-Thomson SJ, Monteith GR
The Journal of biological chemistry 2005 Jul 22;280(29):27076-84
The Journal of biological chemistry 2005 Jul 22;280(29):27076-84
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF
Blood 2005 Jul 15;106(2):542-9
Blood 2005 Jul 15;106(2):542-9
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction.
Nakayama M, Yan X, Price RL, Borg TK, Ito K, Sanbe A, Robbins J, Lorell BH
American journal of physiology. Heart and circulatory physiology 2005 Jan;288(1):H317-27
American journal of physiology. Heart and circulatory physiology 2005 Jan;288(1):H317-27
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
Most P, Boerries M, Eicher C, Schweda C, Völkers M, Wedel T, Söllner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA
Journal of cell science 2005 Jan 15;118(Pt 2):421-31
Journal of cell science 2005 Jan 15;118(Pt 2):421-31
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.
Kettlewell S, Most P, Currie S, Koch WJ, Smith GL
Journal of molecular and cellular cardiology 2005 Dec;39(6):900-10
Journal of molecular and cellular cardiology 2005 Dec;39(6):900-10
The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase.
de Meis L, Oliveira GM, Arruda AP, Santos R, Costa RM, Benchimol M
IUBMB life 2005 Apr-May;57(4-5):337-45
IUBMB life 2005 Apr-May;57(4-5):337-45
Coordinated expression of myosin heavy chains, metabolic enzymes, and morphological features of porcine skeletal muscle fiber types.
Quiroz-Rothe E, Rivero JL
Microscopy research and technique 2004 Sep;65(1-2):43-61
Microscopy research and technique 2004 Sep;65(1-2):43-61
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus.
Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hiesberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ
The Journal of clinical investigation 2004 Nov;114(10):1433-43
The Journal of clinical investigation 2004 Nov;114(10):1433-43
Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells.
Waggoner JR, Huffman J, Griffith BN, Jones LR, Mahaney JE
Protein expression and purification 2004 Mar;34(1):56-67
Protein expression and purification 2004 Mar;34(1):56-67
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.
Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J Jr
The Journal of clinical investigation 2004 Mar;113(5):727-36
The Journal of clinical investigation 2004 Mar;113(5):727-36
Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.
Glover L, Heffron JJ, Ohlendieck K
Journal of applied physiology (Bethesda, Md. : 1985) 2004 Jan;96(1):11-8
Journal of applied physiology (Bethesda, Md. : 1985) 2004 Jan;96(1):11-8
Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet.
Huang Y, Walker KE, Hanley F, Narula J, Houser SR, Tulenko TN
Circulation 2004 Jan 6;109(1):97-102
Circulation 2004 Jan 6;109(1):97-102
Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema.
Kim DK, Zhu J, Kozyak BW, Burkman JM, Rubinstein NA, Lankford EB, Stedman HH, Nguyen T, Levine S, Shrager JB
Respiratory research 2003;4(1):1
Respiratory research 2003;4(1):1
Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema.
Kim DK, Zhu J, Kozyak BW, Burkman JM, Rubinstein NA, Lankford EB, Stedman HH, Nguyen T, Levine S, Shrager JB
Respiratory research 2003;4:1
Respiratory research 2003;4:1
Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx.
del Valle-Rodríguez A, López-Barneo J, Ureña J
The EMBO journal 2003 Sep 1;22(17):4337-45
The EMBO journal 2003 Sep 1;22(17):4337-45
Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity.
de Meis L
The Journal of biological chemistry 2003 Oct 24;278(43):41856-61
The Journal of biological chemistry 2003 Oct 24;278(43):41856-61
Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase.
Arruda AP, Da-Silva WS, Carvalho DP, De Meis L
The Biochemical journal 2003 Nov 1;375(Pt 3):753-60
The Biochemical journal 2003 Nov 1;375(Pt 3):753-60
Increased expression of the nicotinic acetylcholine receptor in stimulated muscle.
O'Reilly C, Pette D, Ohlendieck K
Biochemical and biophysical research communications 2003 Jan 10;300(2):585-91
Biochemical and biophysical research communications 2003 Jan 10;300(2):585-91
Increased expression of the nicotinic acetylcholine receptor in stimulated muscle.
O'Reilly C, Pette D, Ohlendieck K
Biochemical and biophysical research communications 2003 Jan 10;300(2):585-91
Biochemical and biophysical research communications 2003 Jan 10;300(2):585-91
Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.
Kjellgren D, Ryan M, Ohlendieck K, Thornell LE, Pedrosa-Domellöf F
Investigative ophthalmology & visual science 2003 Dec;44(12):5057-62
Investigative ophthalmology & visual science 2003 Dec;44(12):5057-62
Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.
Kjellgren D, Ryan M, Ohlendieck K, Thornell LE, Pedrosa-Domellöf F
Investigative ophthalmology & visual science 2003 Dec;44(12):5057-62
Investigative ophthalmology & visual science 2003 Dec;44(12):5057-62
Use of continuous-elution gel electrophoresis as a preparative tool for blot overlay analysis.
Mulvey C, Ohlendieck K
Analytical biochemistry 2003 Aug 1;319(1):122-30
Analytical biochemistry 2003 Aug 1;319(1):122-30
Supramolecular calsequestrin complex.
Glover L, Quinn S, Ryan M, Pette D, Ohlendieck K
European journal of biochemistry 2002 Sep;269(18):4607-16
European journal of biochemistry 2002 Sep;269(18):4607-16
Supramolecular calsequestrin complex.
Glover L, Quinn S, Ryan M, Pette D, Ohlendieck K
European journal of biochemistry 2002 Sep;269(18):4607-16
European journal of biochemistry 2002 Sep;269(18):4607-16
Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation.
Adachi T, Matsui R, Xu S, Kirber M, Lazar HL, Sharov VS, Schöneich C, Cohen RA
Circulation research 2002 May 31;90(10):1114-21
Circulation research 2002 May 31;90(10):1114-21
Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules.
Tapper H, Furuya W, Grinstein S
Journal of immunology (Baltimore, Md. : 1950) 2002 May 15;168(10):5287-96
Journal of immunology (Baltimore, Md. : 1950) 2002 May 15;168(10):5287-96
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node.
Musa H, Lei M, Honjo H, Jones SA, Dobrzynski H, Lancaster MK, Takagishi Y, Henderson Z, Kodama I, Boyett MR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Mar;50(3):311-24
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Mar;50(3):311-24
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node.
Musa H, Lei M, Honjo H, Jones SA, Dobrzynski H, Lancaster MK, Takagishi Y, Henderson Z, Kodama I, Boyett MR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Mar;50(3):311-24
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Mar;50(3):311-24
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.
Gruijthuijsen YK, Casarosa P, Kaptein SJ, Broers JL, Leurs R, Bruggeman CA, Smit MJ, Vink C
Journal of virology 2002 Feb;76(3):1328-38
Journal of virology 2002 Feb;76(3):1328-38
Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.
Ennis IL, Li RA, Murphy AM, Marbán E, Nuss HB
The Journal of clinical investigation 2002 Feb;109(3):393-400
The Journal of clinical investigation 2002 Feb;109(3):393-400
Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction.
Min JY, Sullivan MF, Yan X, Feng X, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2466-71
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2466-71
Exercise training attenuates coronary smooth muscle phenotypic modulation and nuclear Ca2+ signaling.
Wamhoff BR, Bowles DK, Dietz NJ, Hu Q, Sturek M
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2397-410
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2397-410
Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.
Lockwich T, Singh BB, Liu X, Ambudkar IS
The Journal of biological chemistry 2001 Nov 9;276(45):42401-8
The Journal of biological chemistry 2001 Nov 9;276(45):42401-8
Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status.
Harmon S, Froemming GR, Leisner E, Pette D, Ohlendieck K
Journal of applied physiology (Bethesda, Md. : 1985) 2001 Jan;90(1):371-9
Journal of applied physiology (Bethesda, Md. : 1985) 2001 Jan;90(1):371-9
Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status.
Harmon S, Froemming GR, Leisner E, Pette D, Ohlendieck K
Journal of applied physiology (Bethesda, Md. : 1985) 2001 Jan;90(1):371-9
Journal of applied physiology (Bethesda, Md. : 1985) 2001 Jan;90(1):371-9
Low temperature molecular adaptation of the skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA 1) in the wood frog (Rana sylvatica).
Dode L, Van Baelen K, Wuytack F, Dean WL
The Journal of biological chemistry 2001 Feb 9;276(6):3911-9
The Journal of biological chemistry 2001 Feb 9;276(6):3911-9
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Froemming GR, Murray BE, Harmon S, Pette D, Ohlendieck K
Biochimica et biophysica acta 2000 Jun 1;1466(1-2):151-68
Biochimica et biophysica acta 2000 Jun 1;1466(1-2):151-68
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Froemming GR, Murray BE, Harmon S, Pette D, Ohlendieck K
Biochimica et biophysica acta 2000 Jun 1;1466(1-2):151-68
Biochimica et biophysica acta 2000 Jun 1;1466(1-2):151-68
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC
Proceedings of the National Academy of Sciences of the United States of America 1999 Jan 19;96(2):657-62
Proceedings of the National Academy of Sciences of the United States of America 1999 Jan 19;96(2):657-62
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC
Proceedings of the National Academy of Sciences of the United States of America 1999 Jan 19;96(2):657-62
Proceedings of the National Academy of Sciences of the United States of America 1999 Jan 19;96(2):657-62
Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy.
Ueda H, Shimokawa M, Yamamoto M, Kameda N, Mizusawa H, Baba T, Terada N, Fujii Y, Ohno S, Ishiura S, Kobayashi T
Journal of the neurological sciences 1999 Jan 1;162(1):38-50
Journal of the neurological sciences 1999 Jan 1;162(1):38-50
Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle.
Misquitta CM, Sing A, Grover AK
The Biochemical journal 1999 Feb 15;338 ( Pt 1)(Pt 1):167-73
The Biochemical journal 1999 Feb 15;338 ( Pt 1)(Pt 1):167-73
Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
Patterson RL, van Rossum DB, Gill DL
Cell 1999 Aug 20;98(4):487-99
Cell 1999 Aug 20;98(4):487-99
Ca2+ in the dense tubules: a model of platelet Ca2+ load.
Horiguchi M, Kimura M, Lytton J, Skurnick J, Nash F, Awad G, Poch E, Aviv A
Hypertension (Dallas, Tex. : 1979) 1998 Feb;31(2):595-602
Hypertension (Dallas, Tex. : 1979) 1998 Feb;31(2):595-602
Functional characterization of alternatively spliced human SERCA3 transcripts.
Poch E, Leach S, Snape S, Cacic T, MacLennan DH, Lytton J
The American journal of physiology 1998 Dec;275(6):C1449-58
The American journal of physiology 1998 Dec;275(6):C1449-58
Functional characterization of alternatively spliced human SERCA3 transcripts.
Poch E, Leach S, Snape S, Cacic T, MacLennan DH, Lytton J
The American journal of physiology 1998 Dec;275(6 Pt 1):C1449-58
The American journal of physiology 1998 Dec;275(6 Pt 1):C1449-58
Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i waves.
Lee MG, Xu X, Zeng W, Diaz J, Kuo TH, Wuytack F, Racymaekers L, Muallem S
The Journal of biological chemistry 1997 Jun 20;272(25):15771-6
The Journal of biological chemistry 1997 Jun 20;272(25):15771-6
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.
De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F
The Journal of biological chemistry 1997 Feb 7;272(6):3590-8
The Journal of biological chemistry 1997 Feb 7;272(6):3590-8
Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes.
Negash S, Chen LT, Bigelow DJ, Squier TC
Biochemistry 1996 Sep 3;35(35):11247-59
Biochemistry 1996 Sep 3;35(35):11247-59
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
Hu P, Yin C, Zhang KM, Wright LD, Nixon TE, Wechsler AS, Spratt JA, Briggs FN
The Journal of biological chemistry 1995 May 12;270(19):11619-22
The Journal of biological chemistry 1995 May 12;270(19):11619-22
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
Hu P, Yin C, Zhang KM, Wright LD, Nixon TE, Wechsler AS, Spratt JA, Briggs FN
The Journal of biological chemistry 1995 May 12;270(19):11619-22
The Journal of biological chemistry 1995 May 12;270(19):11619-22
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.
Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, de Gunzburg J, Enouf J
The Biochemical journal 1994 Jan 15;297 ( Pt 2)(Pt 2):343-50
The Biochemical journal 1994 Jan 15;297 ( Pt 2)(Pt 2):343-50
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.
Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, de Gunzburg J, Enouf J
The Biochemical journal 1994 Jan 15;297 ( Pt 2):343-50
The Biochemical journal 1994 Jan 15;297 ( Pt 2):343-50
Biochemical characterization of ultrastructural localization of a major junctional sarcoplasmic reticulum glycoprotein (triadin).
Knudson CM, Stang KK, Jorgensen AO, Campbell KP
The Journal of biological chemistry 1993 Jun 15;268(17):12637-45
The Journal of biological chemistry 1993 Jun 15;268(17):12637-45
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.
Sharp AH, McPherson PS, Dawson TM, Aoki C, Campbell KP, Snyder SH
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Jul;13(7):3051-63
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Jul;13(7):3051-63
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.
Sharp AH, McPherson PS, Dawson TM, Aoki C, Campbell KP, Snyder SH
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Jul;13(7):3051-63
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Jul;13(7):3051-63
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
Jorgensen AO, Shen AC, Arnold W, McPherson PS, Campbell KP
The Journal of cell biology 1993 Feb;120(4):969-80
The Journal of cell biology 1993 Feb;120(4):969-80
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
Jorgensen AO, Shen AC, Arnold W, McPherson PS, Campbell KP
The Journal of cell biology 1993 Feb;120(4):969-80
The Journal of cell biology 1993 Feb;120(4):969-80
Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase.
Molnar E, Varga S, Jona I, Seidler NW, Martonosi A
Biochimica et biophysica acta 1992 Jan 31;1103(2):281-95
Biochimica et biophysica acta 1992 Jan 31;1103(2):281-95
Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase.
Molnar E, Varga S, Jona I, Seidler NW, Martonosi A
Biochimica et biophysica acta 1992 Jan 31;1103(2):281-95
Biochimica et biophysica acta 1992 Jan 31;1103(2):281-95
A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons.
Plessers L, Eggermont JA, Wuytack F, Casteels R
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991 Mar;11(3):650-6
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991 Mar;11(3):650-6
A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons.
Plessers L, Eggermont JA, Wuytack F, Casteels R
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991 Mar;11(3):650-6
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991 Mar;11(3):650-6
Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues.
Spencer GG, Yu XH, Khan I, Grover AK
Biochimica et biophysica acta 1991 Mar 18;1063(1):15-20
Biochimica et biophysica acta 1991 Mar 18;1063(1):15-20
Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues.
Spencer GG, Yu XH, Khan I, Grover AK
Biochimica et biophysica acta 1991 Mar 18;1063(1):15-20
Biochimica et biophysica acta 1991 Mar 18;1063(1):15-20
Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.
Ohlendieck K, Ervasti JM, Snook JB, Campbell KP
The Journal of cell biology 1991 Jan;112(1):135-48
The Journal of cell biology 1991 Jan;112(1):135-48
Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.
Ohlendieck K, Ervasti JM, Snook JB, Campbell KP
The Journal of cell biology 1991 Jan;112(1):135-48
The Journal of cell biology 1991 Jan;112(1):135-48
Analysis of excitation-contraction-coupling components in chronically stimulated canine skeletal muscle.
Ohlendieck K, Briggs FN, Lee KF, Wechsler AW, Campbell KP
European journal of biochemistry 1991 Dec 18;202(3):739-47
European journal of biochemistry 1991 Dec 18;202(3):739-47
Analysis of excitation-contraction-coupling components in chronically stimulated canine skeletal muscle.
Ohlendieck K, Briggs FN, Lee KF, Wechsler AW, Campbell KP
European journal of biochemistry 1991 Dec 18;202(3):739-47
European journal of biochemistry 1991 Dec 18;202(3):739-47
Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle.
Briggs FN, Lee KF, Feher JJ, Wechsler AS, Ohlendieck K, Campbell K
FEBS letters 1990 Jan 1;259(2):269-72
FEBS letters 1990 Jan 1;259(2):269-72
Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles.
Movsesian MA, Leveille C, Krall J, Colyer J, Wang JH, Campbell KP
Journal of molecular and cellular cardiology 1990 Dec;22(12):1477-85
Journal of molecular and cellular cardiology 1990 Dec;22(12):1477-85
The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules.
Molnar E, Seidler NW, Jona I, Martonosi AN
Biochimica et biophysica acta 1990 Apr 13;1023(2):147-67
Biochimica et biophysica acta 1990 Apr 13;1023(2):147-67
A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study.
Jorgensen AO, Arnold W, Pepper DR, Kahl SD, Mandel F, Campbell KP
Cell motility and the cytoskeleton 1988;9(2):164-74
Cell motility and the cytoskeleton 1988;9(2):164-74
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of SERCA2 ATPase was performed by loading 25 µg of rat skeletal muscle (lane 1) and human skeletal muscle (lane 2) onto an SDS polyacrylamide gel. Proteins were transferred to a PVDF membrane and blocked at 4ºC overnight. The membrane was probed with a SERCA2 ATPase monoclonal antibody (Product # MA3-910) at a dilution of 1:1000 (rat muscle) and 1:2000 (human muscle) overnight at 4°C, washed in TBST, and probed with an HRP-conjugated secondary antibody for 1 hr at room temperature in the dark. Chemiluminescent detection was performed using Pierce ECL Plus Western Blotting Substrate (Product # 32132). Results show a band at ~110 kDa.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot was performed using Anti-SERCA2 ATPase Monoclonal Antibody (IID8) (Product # MA3-910) and bands at ~114, 109 kDa corresponding to SERCA2 ATPase was observed across the cell lines tested. Whole cell extracts (30 µg lysate) of A549 (Lane 1), T-47D (Lane 2), PANC-1 (Lane 3), C2C12 (Lane 4), HeLa (Lane 5), MDCK (Lane 6), RD (Lane 7) and Reh (Lane 8) were electrophoresed using Novex® NuPAGE® 4-12% % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000 dilution) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005)..
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SERCA2 ATPase using SERCA2 ATPase Monoclonal antibody (IID8) (Product # MA3-910) shows staining in A549 cells. SERCA2 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing SERCA2 ATPase (Product # MA3-910) at a dilution of 1:100-1:200 over night at 4 °C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35552 for GAR, Product # 35503 for GAM). Images were taken at 60X magnification.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SERCA2 ATPase using SERCA2 ATPase Monoclonal antibody (IID8) (Product # MA3-910) shows staining in HeLa cells. SERCA2 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing SERCA2 ATPase (Product # MA3-910) at a dilution of 1:100-1:200 over night at 4 °C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35552 for GAR, Product # 35503 for GAM). Images were taken at 60X magnification.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SERCA2 ATPase using SERCA2 ATPase Monoclonal antibody (IID8) (Product # MA3-910) shows staining in U251 glioma cells. SERCA2 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing SERCA2 ATPase (Product # MA3-910) at a dilution of 1:100-1:200 over night at 4 °C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35552 for GAR, Product # 35503 for GAM). Images were taken at 60X magnification.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescence analysis of SERCA2 was performed using 70% confluent log phase MDCK cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SERCA2 ATPase Monoclonal Antibody (Product # MA3-910) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: red) was stained with Rhodamine Phalloidin (Product # R415). Panel d represents the merged image showing Cytoplasmic (mostly ER) localization. Panel e represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 4 Changes of ATP2A/SERCA2a and HSPA2 at the mRNA and protein levels in HCM versus control hearts. a A plot of the joint component loadings of RNA-seq data showed ATP2A2 and HSPA2 were two major players in discriminating HCM hearts from controls. The dashed lines on both positive and negative sides indicate the cutoff threshold, with genes with a large contribution to the joint component falling outside of the dash lines. b ATP2A2 mRNA and protein levels in HCM and control samples at the mRNA and protein levels. c HSPA2 mRNA and protein levels expression in HCM and control samples. **: P < 0.01, ***: P < 0.001, ****: P < 0.0001. d Representative immunohistochemistry staining showing higher HSPA2 staining intensity in HCM heart as compared to control. Scale bar = 400 um (control sample) and 800 um (HCM sample). e Representative immunofluorescence staining showing HSPA2 aggregates in an HCM heart (indicated by the arrow), whereas the control shows diffuse staining of the cytoplasm without aggregates. WGA-AF488 appears in gray to visualize the cell membrane, and DAPI appears in blue to visualize the nuclei. Scale bar = 16 um
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 6 Immunofluorescence (IF) staining of selected candidates in control and HCM hiPSC-cardiomyocytes. The same amount of control and HCM hiPSC-cardiomyocytes (20,000 cells per well) were seeded to the plate and cultured for 27 days prior to the staining. a Representative IF staining showing the expression of KLF15 in HCM and control cardiomyocytes (KLF15: red; ACTN2: green; blue: cell nuclei). b Representative IF staining showing disrupted ACTN2 in HCM cardiomyocytes compared to controls (ACTN2: green; blue: cell nuclei). c Representative IF staining showing suppressed ATP2A2 in HCM cardiomyocytes compared to controls (ATP2A2: red; blue: cell nuclei). Nuclei were stained by Hoechst. All overview images were taken at 20 x magnification, scale bar = 100 um. All zoomed regions were taken under Zoom Factor = 1.5
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 7 Variations of gene and protein expression involved in Ca 2+ handling in response to 10-day bed rest Calsequestrin1-2, SERCA1, SERCA2 and TOM20 amount in muscle homogenates as obtained by western blot at baseline (BR0) and after 10 days of bed rest (BR10) ( A ). Representative western blot of CASQ1-2, SERCA1, SERCA2 and TOM20 ( B ). CASQ1 and CASQ2 gene expression (encoding for Calsequestrin1 and Calsequestrin2, respectively) ( C , D ), ATP2A1 and ATP2A2 gene expression (encoding for SERCA1 and SERCA2, respectively) ( E , F ); RYR1 gene expression (encoding for Ryanodine Receptor 1) ( G ). All RNA transcripts are reported as normalized read count at BR0, after 5 days of bed rest (BR5) and at BR10. Results shown as means +- SD, individual data represented as scatter plots. * P < 0.05 BR10 vs BR0, ** P < 0.01 BR10 vs BR0, **** P < 0.0001 BR10 vs BR0.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Nnat increases ER calcium storage by facilitating SERCA function. ( A and B ) Left: cortical neurons were transfected with ER-GCaMP6 or GCaMP6s to measure ER or cytosolic level. Examples of images before and after application of 50 muM IO. Right: quantification of calcium concentration of ER or cytoplasm at rest. Scale bars: 10 mum. n = approximately 42-45 for each group. ( C and D ) Coimmunoprecipitation results showed Nnat could interact with SERCA2 but not IP3R. n = 3 independent experiments. ( E ) Upper left panel: cdn1163 activated SERCA and promoted Ca 2+ influx to ER. Upper right and lower panels: representative time courses of cdn1163 Ca 2+ imaging using GCaMP6s indicator in WT neurons infected with Nnat lentivirus. Individual cell trace (gray) and average trace (black) are shown for each group. ( F ) Upper left panel: CPA inhibited SERCA and promoted Ca 2+ efflux from ER. Upper right and lower panels: representative time courses of CPA Ca 2+ imaging using GCaMP6s indicator in WT neurons infected with Nnat lentivirus. Individual cell trace (gray) and average trace are shown for each group. ( G and I ) Quantification of peak values normalized to control group of cdn1163 Ca 2+ imaging and CPA Ca 2+ imaging. n = approximately 32-38 neurons for cdn1163 Ca 2+ imaging and n = approximately 40-43 neurons for CPA Ca 2+ imaging. ( H and J) Quantification of slope in cdn1163 Ca 2+ imaging and CPA Ca 2+ imaging. n = approximately 43-51 neurons for cdn1163 Ca 2+ imaging and n = a
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 2. A, SERCA-2 mRNA levels assessed from Northern blots decreased within 4 days after initiation of cholesterol feeding and fell to &ap30&percnt from days 8 through 70. B, SERCA-2 protein levels assessed from Western blots remaining unchanged over first 16 days on cholesterol diet and fell &ap55&percnt by day 70. n&equals3 animals per time point. C, Time-dependent SERCA-2 activity assessed with a TSG-sensitive 45 Ca uptake technique into LV SR was decreased &ap50&percnt after 70 days on high-cholesterol diet. n&equals3 control and 3 diet animals Differences between time points were tested with ANOVA with a post hoc Bonferroni correction. Data are mean+-SEM; P
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4 Immunolocalization of myospryn and minispryn in isolated cardiomyocytes. Enzymatically isolated guinea pig ventricular cardiomyocytes were fixed and processed for confocal immunofluorescence microscopy using the indicated antibodies. ( a - c ) At low magnification myospryn (a) immunoreactivity is visible in discontinuous striations that run perpendicular to the long axis of the cardiomyocyte partially overlapping the nucleus (arrow in a). ( d - f ) Higher magnification images show that myospryn immunoreactivity is present in distinct punctae that co-localise with ryanodine receptors (e) in the SR (f and inset). ( g - i ) Anti-minispryn (g) immunoreactivity also appears in discontinuous striations running the length of the cardiomyocyte and is also present in the nucleus (arrow in g). ( j - l ) In common with myospryn, higher magnification images show that minispryn partially co-localises with ryanodine receptors (k) in the SR (l and inset). ( m-o ) Myospryn immunoreactivity overlaps the Z-line labelled with an anti-alpha-actinin antibody (m, n, o). ( p - r ) Similarly, minispryn immunoreactivity also partially overlaps alpha-actinin at the Z-line (p, q, r). ( s - x ) Cardiomyocytes labelled with either anti-SERCA2 (s, t, u) or anti-sarcalumenin (v, w, x) antibodies and myospryn antibodies demonstrate that myospryn immunoreactivity (arrowheads in s) appears to be restricted to the j-SR rather than the l-SR (arrows in t).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Cytoskeletal reorganization does not alter calcium-channel-induced Ca 2+ release in arterial myocytes. ( A ) Example of depolarization (70 mM K + ) and ATP (100 muM) induced Ca 2+ release in a myocyte and confocal fluorescent staining of the cell with markers of the SR (antibodies against Ca ATPase, red) and cytoskeletal microfilaments (antibody against actin, green). ( B ), ( C ) Similar experiments as in (A) performed in cells subjected to prior incubation with calyculin A [(B) 100 nM, 30 min, n = 8 experiments] or jasplakinolide [(C) 1 muM, 120 min, n = 7 experiments]. Note in (B) and (C) the actin ring separating the plasma membrane and the cytosolic organella.
