Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 18280-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18280-1-AP, RRID:AB_2240312
- Product name
- TDP-43 antibody
- Antibody type
- Polyclonal
- Description
- TDP-43 antibody (Cat. #18280-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Icaritin protects SH-SY5Y cells transfected with TDP-43 by alleviating mitochondrial damage and oxidative stress.
First Family of MATR3-Related Distal Myopathy From Italy: The Role of Muscle Biopsy in the Diagnosis and Characterization of a Still Poorly Understood Disease.
Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns.
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology.
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.
Zhou Y, Huang N, Li Y, Ba Z, Zhou Y, Luo Y
PeerJ 2021;9:e11978
PeerJ 2021;9:e11978
First Family of MATR3-Related Distal Myopathy From Italy: The Role of Muscle Biopsy in the Diagnosis and Characterization of a Still Poorly Understood Disease.
Cavalli M, Cardani R, Renna LV, Toffetti M, Villa L, Meola G
Frontiers in neurology 2021;12:715386
Frontiers in neurology 2021;12:715386
Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns.
Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI
Acta neuropathologica communications 2021 Oct 11;9(1):164
Acta neuropathologica communications 2021 Oct 11;9(1):164
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology.
Tian Y, Wang Y, Jablonski AM, Hu Y, Sugam JA, Koglin M, Stachel SJ, Zhou H, Uslaner JM, Parmentier-Batteur S
Neurobiology of disease 2021 Dec;161:105548
Neurobiology of disease 2021 Dec;161:105548
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M
Nature neuroscience 2019 Jan;22(1):65-77
Nature neuroscience 2019 Jan;22(1):65-77
Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.
Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IMY, Jones RA, Coldicott I, Iannitti T, Akaaboune M, El-Khamisy SF, Gillingwater TH, Shaw PJ, Azzouz M
Disease models & mechanisms 2017 Jul 1;10(7):859-868
Disease models & mechanisms 2017 Jul 1;10(7):859-868
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 18280-1-AP(TARDBP antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TARDBP (IP:18280-1-AP, 3ug; Detection:18280-1-AP 1:1500) with K-562 cells lysate 6000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 18280-1-AP(TARDBP antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TDP-43 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TDP-43. This antibody recognizes human,mouse,rat antigen. The TDP-43 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.