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- Antibody Data
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- References [12]
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- Product number
- ABIN188986 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-TAR DNA Binding Protein (TARDBP) (AA 350-414), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Chicken/Avian, Simian, Xenopus, Zebrafish
- Host
- Rabbit
- Epitope
- C-Term, AA 350-414
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
TDP-43 dimerizes in human cells in culture.
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Li Q, Yokoshi M, Okada H, Kawahara Y
Nature communications 2015 Jan 29;6:6183
Nature communications 2015 Jan 29;6:6183
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S
Acta neuropathologica communications 2015 Apr 1;3:15
Acta neuropathologica communications 2015 Apr 1;3:15
Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.
Fang YS, Tsai KJ, Chang YJ, Kao P, Woods R, Kuo PH, Wu CC, Liao JY, Chou SC, Lin V, Jin LW, Yuan HS, Cheng IH, Tu PH, Chen YR
Nature communications 2014 Sep 12;5:4824
Nature communications 2014 Sep 12;5:4824
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH
Human molecular genetics 2014 Jan 1;23(1):157-70
Human molecular genetics 2014 Jan 1;23(1):157-70
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 26;110(13):4986-91
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 26;110(13):4986-91
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Kawahara Y, Mieda-Sato A
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3347-52
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3347-52
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M
Human molecular genetics 2011 Sep 15;20(18):3642-52
Human molecular genetics 2011 Sep 15;20(18):3642-52
TDP-43 dimerizes in human cells in culture.
Shiina Y, Arima K, Tabunoki H, Satoh J
Cellular and molecular neurobiology 2010 May;30(4):641-52
Cellular and molecular neurobiology 2010 May;30(4):641-52
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3;106(44):18809-14
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3;106(44):18809-14
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ
Archives of neurology 2008 May;65(5):636-41
Archives of neurology 2008 May;65(5):636-41
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, Kirby J, Siddique T, Shaw PJ, Lee VM, Trojanowski JQ
Annals of neurology 2007 May;61(5):427-34
Annals of neurology 2007 May;61(5):427-34
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM
Science (New York, N.Y.) 2006 Oct 6;314(5796):130-3
Science (New York, N.Y.) 2006 Oct 6;314(5796):130-3
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Supportive validation
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- Main image
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