308805

antibody from BioLegend

Targeting: IL10RA CD210, CD210a, CDW210A, HIL-10R, IL10R

Immunoprecipitation (Recommended by provider)

Flow cytometry (Supportive data in Antibodypedia)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

308805

Provider

BioLegend

Proper citation

BioLegend Cat#308805, RRID:AB_314737

Product name

LEAF™ purified anti-human CD210 (IL-10 R) [3F9]

Antibody type

Monoclonal

Antigen

CD210 (IL-10 R)

Description

CD210, also known as the IL-10 receptor, is a 90-110 kD protein expressed on T cells, B cells, NK cells, monocytes and macrophages. CD210 belongs to the class II cytokine receptor family which includes the IFN-γ receptor (CDw119), the IFN-α/β receptor (CD118) and tissue factor (CD142). The IL-10 receptor is involved in signal transduction by inducing phosphorylation of STAT1a and STAT3 and by inducing activation of Jak1 and Tyk.

Reactivity

Human, Simian

Host

Rat

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 µg

Concentration

1 mg/ml

Storage

The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

References

Submitted references

Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections.

Liu BS, Groothuismink ZM, Janssen HL, Boonstra A
Journal of leukocyte biology 2011 Jun;89(6):981-8

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T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible.

Huang YH, Zozulya AL, Weidenfeller C, Schwab N, Wiendl H
Journal of leukocyte biology 2009 Aug;86(2):273-81

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood lymphocytes stained with LEAF™ purified 3F9, followed by biotinylated anti-rat IgG and Sav-PE

Conjugate

Unconjugated