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- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10294-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10294-2-AP, RRID:AB_2162153
- Product name
- CCM3/PDCD10 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CCM3/PDCD10 antibody (Cat. #10294-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling.
Cerebral cavernous malformation 3 relieves subarachnoid hemorrhage-induced neuroinflammation in rats through inhibiting NF-kB signaling pathway.
Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure.
A single-center study on 140 patients with cerebral cavernous malformations: 28 new pathogenic variants and functional characterization of a PDCD10 large deletion.
Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3.
Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.
Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.
A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.
PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
Sun B, Zhong FJ, Xu C, Li YM, Zhao YR, Cao MM, Yang LY
Cell death & disease 2021 Sep 14;12(9):849
Cell death & disease 2021 Sep 14;12(9):849
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling.
Wang S, Englund E, Kjellman P, Li Z, Ahnlide JK, Rodriguez-Cupello C, Saggioro M, Kanzaki R, Pietras K, Lindgren D, Axelson H, Prinz CN, Swaminathan V, Madsen CD
Nature cell biology 2021 Jul;23(7):758-770
Nature cell biology 2021 Jul;23(7):758-770
Cerebral cavernous malformation 3 relieves subarachnoid hemorrhage-induced neuroinflammation in rats through inhibiting NF-kB signaling pathway.
Peng W, Wu X, Feng D, Zhang Y, Chen X, Ma C, Shen H, Li X, Li H, Zhang J, Chen G
Brain research bulletin 2020 Jul;160:74-84
Brain research bulletin 2020 Jul;160:74-84
Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure.
Johnson AM, Roach JP, Hu A, Stamatovic SM, Zochowski MR, Keep RF, Andjelkovic AV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2615-2629
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2615-2629
A single-center study on 140 patients with cerebral cavernous malformations: 28 new pathogenic variants and functional characterization of a PDCD10 large deletion.
Nardella G, Visci G, Guarnieri V, Castellana S, Biagini T, Bisceglia L, Palumbo O, Trivisano M, Vaira C, Scerrati M, Debrasi D, D'Angelo V, Carella M, Merla G, Mazza T, Castori M, D'Agruma L, Fusco C
Human mutation 2018 Dec;39(12):1885-1900
Human mutation 2018 Dec;39(12):1885-1900
Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3.
Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W, He Y
Toxicology letters 2016 Jul 8;254:22-31
Toxicology letters 2016 Jul 8;254:22-31
Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.
Louvi A, Nishimura S, Günel M
Development (Cambridge, England) 2014 Mar;141(6):1404-15
Development (Cambridge, England) 2014 Mar;141(6):1404-15
Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.
Fidalgo M, Guerrero A, Fraile M, Iglesias C, Pombo CM, Zalvide J
The Journal of biological chemistry 2012 Mar 30;287(14):11556-65
The Journal of biological chemistry 2012 Mar 30;287(14):11556-65
A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Fuller SJ, McGuffin LJ, Marshall AK, Giraldo A, Pikkarainen S, Clerk A, Sugden PH
The Biochemical journal 2012 Mar 15;442(3):595-610
The Biochemical journal 2012 Mar 15;442(3):595-610
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.
Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY
The Journal of clinical investigation 2011 May;121(5):1871-81
The Journal of clinical investigation 2011 May;121(5):1871-81
PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.
Lin C, Meng S, Zhu T, Wang X
The Journal of biological chemistry 2010 Dec 31;285(53):41675-85
The Journal of biological chemistry 2010 Dec 31;285(53):41675-85
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
Fidalgo M, Fraile M, Pires A, Force T, Pombo C, Zalvide J
Journal of cell science 2010 Apr 15;123(Pt 8):1274-84
Journal of cell science 2010 Apr 15;123(Pt 8):1274-84
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10294-2-AP(PDCD10 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-PDCD10 (IP:10294-2-AP, 3ug; Detection:10294-2-AP 1:300) with mouse skeletal muscle tissue lysate 7500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDCD10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDCD10. This antibody recognizes human,mouse,rat antigen. The PDCD10 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
