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- Product number
- GTX103197 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX103197, RRID:AB_2036774
- Product name
- DNA ligase III antibody [C2C3], C-term
- Antibody type
- Polyclonal
- Reactivity
- Human, Hamster
- Host
- Rabbit
Submitted references Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress.
DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair.
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Campalans A, Moritz E, Kortulewski T, Biard D, Epe B, Radicella JP
Molecular and cellular biology 2015 May;35(9):1648-58
Molecular and cellular biology 2015 May;35(9):1648-58
DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair.
Abdou I, Poirier GG, Hendzel MJ, Weinfeld M
Nucleic acids research 2015 Jan;43(2):875-92
Nucleic acids research 2015 Jan;43(2):875-92
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Truong LN, Li Y, Shi LZ, Hwang PY, He J, Wang H, Razavian N, Berns MW, Wu X
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):7720-5
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):7720-5
Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Kim S, Jo S, Lee H, Kim TU, Kim IC, Yim JH, Chung H
Anticancer research 2013 Dec;33(12):5445-51
Anticancer research 2013 Dec;33(12):5445-51
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Enhanced validation
Supportive validation
- Submitted by
- GeneTex (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) 293T whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase III antibody [C2C3], C-term (GTX103197) diluted at 1:500.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- HepG2 whole cell and nuclear extracts (30 £gg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase III antibody [C2C3], C-term (GTX103197) diluted at 1:500.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) 293T whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase III antibody [C2C3], C-term (GTX103197) diluted at 1:500.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- DNA ligase III antibody [C2C3], C-term detects DNA ligase III protein at nucleus by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: DNA ligase III protein stained by DNA ligase III antibody [C2C3], C-term (GTX103197) diluted at 1:200.Red: phalloidin, a cytoskeleton marker, diluted at 1:200.Scale bar = 10 £gm.
