11279-1-AP

antibody from Proteintech Group

Targeting: PRMT1 ANM1, HCP1, HRMT1L2

Provider product page for 11279-1-AP

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References [24]
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Immunohistochemistry [1]

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Product number: 11279-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11279-1-AP, RRID:AB_2171319
Product name: PRMT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PRMT1 antibody (Cat. #11279-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRMT1 protein structure - 11279-1-AP shown in red.

Submitted references A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.

Chang A, Peng H, Chen Y, Zhang H, Xu X, Zhang K, Yang J, Li W, Wang X, Dong X, Ni J
Biomaterials 2026 Oct;333:124215

Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.

Yang X, Zou Y, Wang H, Niu Y, Fu L
Sports medicine and health science 2026 Mar;8(2):197-209

Research on the compatibility mechanism of the Tingli Dazao Xiefei Decoction by multi-organ metabolomics strategy.

Wang RF, Yuan PP, Chen L, Zhang ZK, Zhang BX, Chen L, Yuan SM, Zhao YF, Zhou N, Zheng XK, Feng WS
Journal of ethnopharmacology 2026 Jun 28;365:121548

PRMT1-Mediated PARP1 Methylation Drives Lung Metastasis and Chemoresistance via P65 Activation in Triple-Negative Breast Cancer.

Zhang J, Huang Z, Song C, Wu S, Xie J, Zou Y, Xie X, Wu T, Yang H, Tang H
Research (Washington, D.C.) 2025;8:0854

LncRNA 91234.1 targets PRMT1/ASCL4/GPX4 axis to regulate formaldehyde-induced cardiomyocyte ferroptosis and congenital heart disease.

Zhao S, Sun P, Wang C, Li X, Xiu Z, Tian Y, Song X, He X, Yu T, Jiang Z
Journal of molecular and cellular cardiology 2025 Sep;206:76-90

ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth.

Tao J, Wang Z, Shi R, Lin L, Li M, Meng Y, Luo S, Jiang X, Guo Z, Shang Y, Lu Z
Nature structural & molecular biology 2025 May;32(5):853-863

PRMT1 Upregulates SIRT6 by Enhancing Arginine Methylation of E2F7 to Inhibit Vascular Smooth Muscle Cell Senescence in Aortic Dissection.

Wu Y, Qin X, Xiang M, Deng J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70579

TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.

Cao M, Shao Z, Qian X, Chen M, Deng C, Chen X, Tang T, Zhang K, Chu S, Zheng J, Bai J, Li Z
Cell death & disease 2025 Jan 31;16(1):56

Dual recombinase-mediated intersectional genetics defines the functional heterogeneity of neural stem cells in adult hippocampus.

Liang Z, Li Z, Zhang D, Luo X, Liu Q, Qin D, Wang M, Xu Z, Feng J, He J, Guo W
Molecular psychiatry 2025 Aug;30(8):3516-3532

Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.

Zhong Y, Fan D, Zhang P, Mao X, Liu B, Wang C, Li Q
Journal of the American Heart Association 2025 Aug 19;14(16):e041440

Fructose-induced progression of steatohepatitis involves disrupting aldolase B-AMPK signaling in methionine adenosyltransferase 1A deficient mice.

Barbier-Torres L, Luque-Urbano M, Chhimwal J, Robinson AE, Fernández-Ramos D, Lopitz-Otsoa F, Van Eyk JE, Millet O, Mato JM, Lu SC
Metabolism: clinical and experimental 2025 Apr;165:156154

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility.

Choi H, Zhou L, Zhao Y, Dean J
Nucleic acids research 2024 Oct 28;52(19):11973-11994

PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.

Nguyen CDK, Colón-Emeric BA, Murakami S, Shujath MNY, Yi C
Cell reports 2024 May 28;43(5):114176

PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.

Vijayakumar A, Majumder M, Yin S, Brobbey C, Karam J, Howley B, Howe PH, Berto S, Madan LK, Gan W, Palanisamy V
Nucleic acids research 2024 Jul 8;52(12):7225-7244

PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis.

Liu H, Chen X, Wang P, Chen M, Deng C, Qian X, Bai J, Li Z, Yu X
Cell death & disease 2024 Feb 24;15(2):170

Cingulate protein arginine methyltransferases 1 regulates peripheral hypersensitivity via fragile X messenger ribonucleoprotein.

Wu C, Shang HF, Wang YJ, Wang JH, Zuo ZX, Lian YN, Liu L, Zhang C, Li XY
Frontiers in molecular neuroscience 2023;16:1153870

The SMARCA4(R1157W) mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer.

Zeng X, Yao B, Liu J, Gong GW, Liu M, Li J, Pan HF, Li Q, Yang D, Lu P, Wu D, Xu P, Chen B, Chen P, Zhang M, Zen K, Jing J, Huang DCS, Chen D, Jiang ZW, Zhao Q
NPJ precision oncology 2023 Mar 15;7(1):28

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Li Q, Zhang L, Yang Q, Li M, Pan X, Xu J, Zhong C, Yao F, Zhang R, Zhou S, Dai X, Shi X, Dai Y, Xu J, Cheng X, Xiao W, She Z, Wang K, Qian X, Pu L, Zhang P, Wang X
Cell metabolism 2023 Jun 6;35(6):912-927.e7

PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.

Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W
Cell metabolism 2023 Dec 5;35(12):2183-2199.e7

PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.

Zhong Y, Wang Y, Li X, Qin H, Yan S, Rao C, Fan D, Liu D, Deng F, Miao Y, Yang L, Huang K
Diabetes 2023 Aug 1;72(8):1095-1111

Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5.

Zhang Q, Yang R, Tian Y, Ge S, Nan X, Zhu S, Dong S, Zhang B
Basic & clinical pharmacology & toxicology 2022 Jul;131(1):18-33

Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5.

Tian Y, Yang W, Yang R, Zhang Q, Hao L, Bian E, Yang Y, Huang X, Wu Y, Zhang B
Toxicology and applied pharmacology 2022 Jan 15;435:115829

PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis.

Li Z, Wang D, Chen X, Wang W, Wang P, Hou P, Li M, Chu S, Qiao S, Zheng J, Bai J
Cell death & disease 2021 Nov 13;12(11):1080

PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.

Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB
Oncogene 2021 Feb;40(7):1375-1389

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PRMT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRMT1. This antibody recognizes human, mouse, rat antigen. The PRMT1 antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 11279-1-AP.pdf

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