679102

antibody from BioLegend

Targeting: CARD9

Western blot

Immunocytochemistry

Antibody data

Submit

Validation data

Product number: 679102 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#679102, RRID:AB_2566076
Product name: Purified anti-CARD9
Antibody type: Monoclonal
Antigen: Human CARD9 peptide (LRKMQKGWRQGEEDRENT) conjugated to KLH.
Description: Caspase recruitment domain-containing protein 9 (CARD9) is a member of the CARD protein family, which is known to play regulatory roles in cell apoptosis. CARD9 is an adaptor protein that mediates the signaling downstream of C-type lectin receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle. CARD9 also participates in the signaling downstream of the Retinoic acid-inducible gene I receptor (RIG-1) family. After stimulation of the receptors, CARD9 is phosphorylated and forms a trimolecular complex with B cell leukemia-lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1), which activates the canonical NF-κB pathway and leads to the induction of proimflammatory cytokines, including IL-6, IL-1β, and tumor necrosis factors-alpha (TNFs). CARD9 has been suggested to play an important role in antifungal host defense, as the CARD9 deficient mice are more susceptible to pathogenic fungi infections.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: 13D9C60
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: 2°C-8°C
Handling: Ambient RT

CARD9 protein structure - 679102 shown in red.