ABIN499883

antibody from antibodies-online

Targeting: GFRA1 GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1

Western blot (Supportive data in Antibodypedia)

ELISA (Recommended by provider)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN499883

Provider

antibodies-online

Product name

anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody

Antibody type

Polyclonal

Antigen

Human GFR alpha 1 (Intermediate Domain) Peptide (AP30361CP-N)

Description

DEAE Chromatography

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

Intermediate Domain

Isotype

IgG

Vial size

0.1 mg

Concentration

1.0 mg/mL

Storage

Store the antibody undiluted at 2-8°C.

References

Submitted references

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.

Buj-Bello A, Adu J, Piñón LG, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM
Nature 1997 Jun 12;387(6634):721-4

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Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.

Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL
Proceedings of the National Academy of Sciences of the United States of America 1997 Jun 10;94(12):6238-43

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GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.

Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM
Cell 1996 Jun 28;85(7):1113-24

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Characterization of a multicomponent receptor for GDNF.

Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A
Nature 1996 Jul 4;382(6586):80-3

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with AP30361PU-N GFR alpha 1 antibody at 1/500 dilution.

Immunohistochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Immunohistochemistry of GFR alpha 1 in human brain tissue with AP30361PU-N GFR alpha 1 antibody at 1 ?g/ml.