ABIN499883
antibody from antibodies-online
Targeting: GFRA1
GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- ABIN499883 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody
- Antibody type
- Polyclonal
- Antigen
- Human GFR alpha 1 (Intermediate Domain) Peptide (AP30361CP-N)
- Description
- DEAE Chromatography
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Intermediate Domain
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/mL
- Storage
- Store the antibody undiluted at 2-8°C.
Submitted references Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.
Characterization of a multicomponent receptor for GDNF.
Buj-Bello A, Adu J, Piñón LG, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM
Nature 1997 Jun 12;387(6634):721-4
Nature 1997 Jun 12;387(6634):721-4
Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.
Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL
Proceedings of the National Academy of Sciences of the United States of America 1997 Jun 10;94(12):6238-43
Proceedings of the National Academy of Sciences of the United States of America 1997 Jun 10;94(12):6238-43
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.
Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM
Cell 1996 Jun 28;85(7):1113-24
Cell 1996 Jun 28;85(7):1113-24
Characterization of a multicomponent receptor for GDNF.
Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A
Nature 1996 Jul 4;382(6586):80-3
Nature 1996 Jul 4;382(6586):80-3
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with AP30361PU-N GFR alpha 1 antibody at 1/500 dilution.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of GFR alpha 1 in human brain tissue with AP30361PU-N GFR alpha 1 antibody at 1 ?g/ml.