13588-1-AP
antibody from Proteintech Group
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Antibody data
- Antibody Data
- Antigen structure
- References [83]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 13588-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13588-1-AP, RRID:AB_2114429
- Product name
- Granzyme B antibody
- Antibody type
- Polyclonal
- Description
- Granzyme B antibody (Cat. #13588-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma.
DMNQ induces ferroptosis and augments the efficacy of anti-PD-L1 immunotherapy in gastric cancer via the STAT3/SLC1A4 axis to mediate cysteine metabolism reprogramming.
Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist.
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.
CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma.
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD-L1 Expression and Acts as a Target to Enhance Anti-PD-1 Efficacy.
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Metabolic reprogramming in lacrimal gland GVHD: Stage-specific shifts in acinar cells as drivers of disease progression.
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.
PRMT5-Mediated Arginine Methylation of ACSL4 Attenuates Its Stability and Suppresses Ferroptosis in Renal Cancer.
Identifying the Key Mitochondria-Related Genes in COPD by Integrating Machine Learning and Bioinformatics Analyses.
Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model.
Development and Validation of an Anoikis-Related Gene Signature for Prognostic Prediction in Cervical Cancer.
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
Light-controlled pyroptosis via redox-responsive microneedles enhances photodynamic-epigenetic immunotherapy in breast cancer.
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression.
Iron overload-induced ferroptosis in CD8(+) T cells leads to functional abnormalities that promote endometriosis progression.
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity.
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.
Multimodal spatial proteomic profiling in acute myeloid leukemia.
Targeting MAPK14 by Lobeline Upregulates Slurp1-Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth.
Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors.
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer.
Peptide-based CAR-NK cells: A novel strategy for the treatment of solid tumors.
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
Anti-Her2 CAR-NK92 Cells and Their Exosomes: Generation, Characterization, and Selective Cytotoxicity Against Her2-Positive Tumor Cells.
NAD(+) Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment.
Granzyme B as a potential biological target in toxic encephalopathy: A big data-based exploratory analysis.
Overcoming immunotherapy resistance in bladder cancer with a novel antibody-drug conjugate RC48.
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma.
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
CD161(+)CD127(+)CD8(+) T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus.
The peptide-based bispecific CAR T cells target EGFR and tumor stroma for effective cancer therapy.
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC.
The prognostic and therapeutic value of the tumor microenvironment and immune checkpoints in pancreatic neuroendocrine neoplasms.
In situ editing of tumour cell membranes induces aggregation and capture of PD-L1 membrane proteins for enhanced cancer immunotherapy.
Antitumor effects of IOX1 combined with bevacizumab-induced apoptosis and immunity on colorectal cancer cells.
Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade.
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments.
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Tumorous IRE1α facilitates CD8(+)T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma.
Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.
Sulforaphane impaired immune checkpoint blockade therapy through activating ΔNP63α/PD-L1 axis in gastric cancer.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.
Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel.
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
A novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in triple negative breast cancer.
Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Exploring the effect of polyamines on NK cell function in colorectal cancer process based on glycolysis.
Reforming the Chimeric Antigen Receptor by Peptide Towards Optimized CAR T Cells With Enhanced Anti-Cancer Potency and Safety.
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE).
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy.
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.
Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features.
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.
Gao X, Xu M, Han Z, Hu Z, Su Y, Sun G, Chen W, Qiu S, Qiu S, Hung MC, Zhou C, Yi Y
Cancer letters 2026 May 1;645:218395
Cancer letters 2026 May 1;645:218395
DMNQ induces ferroptosis and augments the efficacy of anti-PD-L1 immunotherapy in gastric cancer via the STAT3/SLC1A4 axis to mediate cysteine metabolism reprogramming.
Zhu W, Qi H, Jing F, Shi Y, Xing Y, Ma X, Ning B, Wang Y, Jia Y
Redox biology 2026 Mar;90:104055
Redox biology 2026 Mar;90:104055
Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist.
Zhao X, Gao L, Chen R, Tian H, Liang S, Zhang Z, Li W, Sun J, Chen X, Tang X, Lan T, Sun Y, Ma J
Oncogene 2026 Mar;45(9):809-822
Oncogene 2026 Mar;45(9):809-822
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
Huo L, Wu C, Li X, Ma C, Huang J, Chen Z, He W, Tao T, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Lin L, Li X, Guo W, Xie J, Li X, Guan X, Zhao C, Yin H, Xu H
Cell reports. Medicine 2026 Mar 17;7(3):102658
Cell reports. Medicine 2026 Mar 17;7(3):102658
Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.
Tian HX, Ruan QZ, Xie YZ, Chen W, Xiao C, Zhong W, Liu YC, Chen SD, Yong TQ, Hu HP, Li XM, Wu QP
Carbohydrate polymers 2026 Jun 15;382:125254
Carbohydrate polymers 2026 Jun 15;382:125254
CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma.
Xiao M, Qiu L, Gao Q, Li R, Wang J, Feng Y, Li X, Ge X
Cells 2026 Jan 30;15(3)
Cells 2026 Jan 30;15(3)
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Du L, Zhang X, Gong Y, Liu M, Sun J, Hu X, Peng J, Liu Z, Zhang T, Xu J, Gao F, Cheng W
Materials today. Bio 2026 Feb;36:102702
Materials today. Bio 2026 Feb;36:102702
Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD-L1 Expression and Acts as a Target to Enhance Anti-PD-1 Efficacy.
Hu Y, Tang L, Kuang Z, Huang D, Li T, Yin G, Chen Y, Guo W, Han W, Wang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e14347
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e14347
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Zhang Y, Shao Y, Li X, Zhou D, Zhou J, Yan Q, Gao W, Yang L
Communications biology 2026 Feb 7;9(1)
Communications biology 2026 Feb 7;9(1)
Metabolic reprogramming in lacrimal gland GVHD: Stage-specific shifts in acinar cells as drivers of disease progression.
Jin K, Wang N, Mou C, Yuan K, Wang C, Yuan J, Zheng F, Fang Z, Jin X, He J, Wang Q, Yang S
The ocular surface 2026 Apr;40:89-104
The ocular surface 2026 Apr;40:89-104
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
Ge Y, Zhou Q, Zhang Q, Hu Y, Wang R
Cancer immunology, immunotherapy : CII 2026 Apr 21;75(5)
Cancer immunology, immunotherapy : CII 2026 Apr 21;75(5)
A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.
Yu K, Sun X, Ma W, Yang J, Sun X, Zhang L, Liu Y, Ren T, Wang Q, Wang J, Li X, Peng X, Yang L, Lv J, Yao Z, Zhang ZS, Wang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 13;:e20095
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 13;:e20095
PRMT5-Mediated Arginine Methylation of ACSL4 Attenuates Its Stability and Suppresses Ferroptosis in Renal Cancer.
Zhang M, Liu H, Yin R, Xu J, Fan S, Qian X, Cao M, Li S, Zhang A, Chen G, Yong H, Li Z, Bai J
Research (Washington, D.C.) 2025;8:0789
Research (Washington, D.C.) 2025;8:0789
Identifying the Key Mitochondria-Related Genes in COPD by Integrating Machine Learning and Bioinformatics Analyses.
Qu J, Zhang M, Hu Y, Yang G, Zhang X, Zhang W, Qu Y
International journal of genomics 2025;2025:7060748
International journal of genomics 2025;2025:7060748
Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model.
Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL
International journal of nanomedicine 2025;20:3083-3111
International journal of nanomedicine 2025;20:3083-3111
Development and Validation of an Anoikis-Related Gene Signature for Prognostic Prediction in Cervical Cancer.
Meng S, Li X, Zhang J, Cheng X
International journal of general medicine 2025;18:2861-2879
International journal of general medicine 2025;18:2861-2879
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Feng C, Liu Y, Zhong X, Wei Z, Cui H, Yi J
Frontiers in immunology 2025;16:1692864
Frontiers in immunology 2025;16:1692864
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
Si C, Wang Y, Li Y, Chen Y, Fan Y, Wang Y, Tian Y, Gao J, Ma X
Frontiers in immunology 2025;16:1613178
Frontiers in immunology 2025;16:1613178
Light-controlled pyroptosis via redox-responsive microneedles enhances photodynamic-epigenetic immunotherapy in breast cancer.
Yu H, Chen Y, Yin J, Yuan Z, Feng S, Duan Y, Yan P, Liu S, Zhu W
Materials today. Bio 2025 Oct;34:102158
Materials today. Bio 2025 Oct;34:102158
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
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Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression.
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European journal of pharmacology 2025 Oct 5;1004:177984
European journal of pharmacology 2025 Oct 5;1004:177984
Iron overload-induced ferroptosis in CD8(+) T cells leads to functional abnormalities that promote endometriosis progression.
Wang S, Xu L, Jiao X, Dong X, Zhong Z, Ren Q, Liu X, Yuan M, Wang G
BMC medicine 2025 Oct 27;23(1):588
BMC medicine 2025 Oct 27;23(1):588
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity.
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Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 May;80:101222
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Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2407575
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Ly CP, Veletic I, Pacheco CD, Dasdemir E, Jelloul FZ, Ferri-Borgogno S, Basi AV, Gomez JA, Root JL, Reville PK, Jindal S, Basu S, Sharma P, Quesada AE, Bueso-Ramos C, Manshouri T, Cuglievan B, Garcia M, Burks JK, Abbas HA
NPJ precision oncology 2025 May 20;9(1):148
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Targeting MAPK14 by Lobeline Upregulates Slurp1-Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth.
Zhao M, Zhou L, Zhang Q, Wang M, Dong Y, Wang Y, Pei R, He E, Liang Y, Shen Y, Deng G, Chen H, Sun D, Shen Y, Sun Y, Cheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2407900
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2407900
Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors.
Wang X, Fang H, Hu W, Feng Y, Zhou Z, Hu M, Jiang D, Zhang Y, Lan X
Journal of nanobiotechnology 2025 Mar 7;23(1):186
Journal of nanobiotechnology 2025 Mar 7;23(1):186
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
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Materials today. Bio 2025 Jun;32:101650
Materials today. Bio 2025 Jun;32:101650
Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer.
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Biochemical pharmacology 2025 Feb;232:116741
Biochemical pharmacology 2025 Feb;232:116741
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.
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Cell metabolism 2025 Feb 4;37(2):514-526.e5
Cell metabolism 2025 Feb 4;37(2):514-526.e5
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
Wang L, Wang J, Wang N, Wang X, Song M, Zhou Y, Wang Z, Meng H, Guo E, Miao S
iScience 2025 Feb 21;28(2):111633
iScience 2025 Feb 21;28(2):111633
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
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Nature communications 2025 Dec 13;17(1):440
Nature communications 2025 Dec 13;17(1):440
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
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Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Anti-Her2 CAR-NK92 Cells and Their Exosomes: Generation, Characterization, and Selective Cytotoxicity Against Her2-Positive Tumor Cells.
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International journal of molecular sciences 2025 Aug 7;26(15)
International journal of molecular sciences 2025 Aug 7;26(15)
NAD(+) Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment.
Shen J, Xu F, Liu T, Ye Y, Xu S
Cell death & disease 2025 Aug 23;16(1):640
Cell death & disease 2025 Aug 23;16(1):640
Granzyme B as a potential biological target in toxic encephalopathy: A big data-based exploratory analysis.
Liu L, Wang J, Liu C
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Medicine 2025 Aug 15;104(33):e43879
Overcoming immunotherapy resistance in bladder cancer with a novel antibody-drug conjugate RC48.
Xiao J, Liu J, Zhang C, Liu Z, Nie Z, Yi Z, Gao X, Liang H, Huang J, Cai Z, Yan L, Wu B, Liu Z, Chen J, Zu X, Hu J
Journal for immunotherapy of cancer 2025 Aug 11;13(8)
Journal for immunotherapy of cancer 2025 Aug 11;13(8)
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Li D, Liu X, Gao W, Zhao W, Ji S, Wang S, Yang J, Li D, Chang Z, Chen Y, Sun X, Zhou J, Jiao Y, Du X, Dong G
Cancer research 2025 Apr 15;85(8):1441-1458
Cancer research 2025 Apr 15;85(8):1441-1458
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.
Wei W, Li H, Tian S, Zhang C, Liu J, Tao W, Cai T, Dong Y, Wang C, Lu D, Ai Y, Zhang W, Wang H, Liu K, Fan Y, Gao Y, Huang Q, Ma X, Wang B, Zhang X, Huang Y
The Journal of clinical investigation 2025 Apr 15;135(8)
The Journal of clinical investigation 2025 Apr 15;135(8)
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Ji S, Cao L, Gao J, Du Y, Ye Z, Lou X, Liu F, Zhang Y, Xu J, Shi X, Wang H, Li P, Li Y, Chen H, Yang Z, Gao S, Zhang W, Huang D, Ni S, Wei M, Wang F, Wang Y, Ding T, Jing D, Fan G, Gong Z, Lu R, Qin Y, Chen J, Xu X, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Chang DK, Hruban RH, Gao D, Gao D, Jin G, Zhou H, Wu J, Yu X
Cancer cell 2025 Apr 14;43(4):776-796.e14
Cancer cell 2025 Apr 14;43(4):776-796.e14
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma.
Zhai Y, Li G, Pan C, Yu M, Hu H, Wang D, Shi Z, Jiang T, Zhang W
Cancer letters 2025 Apr 1;614:217541
Cancer letters 2025 Apr 1;614:217541
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
Chen H, Lu Z, Ni X, Zhang H, Chen G, Wu X, Ding M
Immunotherapy 2024;16(14-15):975-985
Immunotherapy 2024;16(14-15):975-985
CD161(+)CD127(+)CD8(+) T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus.
Qu J, Li Y, Wu B, Shen Q, Chen L, Sun W, Wang B, Ying L, Wu L, Zhou H, Zhou J, Zhou J
Oncoimmunology 2024;13(1):2371575
Oncoimmunology 2024;13(1):2371575
The peptide-based bispecific CAR T cells target EGFR and tumor stroma for effective cancer therapy.
Liu C, Wang Q, Li L, Gao F, Zhang Y, Zhu Y
International journal of pharmaceutics 2024 Sep 30;663:124558
International journal of pharmaceutics 2024 Sep 30;663:124558
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC.
Li F, Shi Y, Ma M, Yang X, Chen X, Xie Y, Liu S
Journal of pharmaceutical analysis 2024 Oct;14(10):100977
Journal of pharmaceutical analysis 2024 Oct;14(10):100977
The prognostic and therapeutic value of the tumor microenvironment and immune checkpoints in pancreatic neuroendocrine neoplasms.
Chen Z, Lin S, Liang F, Hou Z, Yang Y, Huang H, Pan Y
Scientific reports 2024 Oct 21;14(1):24669
Scientific reports 2024 Oct 21;14(1):24669
In situ editing of tumour cell membranes induces aggregation and capture of PD-L1 membrane proteins for enhanced cancer immunotherapy.
Mao C, Deng F, Zhu W, Xie L, Wang Y, Li G, Huang X, Wang J, Song Y, Zeng P, He Z, Guo J, Suo Y, Liu Y, Chen Z, Yao M, Zhang L, Shen J
Nature communications 2024 Nov 9;15(1):9723
Nature communications 2024 Nov 9;15(1):9723
Antitumor effects of IOX1 combined with bevacizumab-induced apoptosis and immunity on colorectal cancer cells.
Fang S, Cao H, Liu J, Cao G, Li T
International immunopharmacology 2024 Nov 15;141:112896
International immunopharmacology 2024 Nov 15;141:112896
Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade.
Fu M, Zhao J, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y, Hua W, Mao Y
Cancer cell 2024 Nov 11;42(11):1882-1897.e7
Cancer cell 2024 Nov 11;42(11):1882-1897.e7
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments.
Chen T, Deng J, Zhang Y, Liu B, Liu R, Zhu Y, Zhou M, Lin Y, Xia B, Lin K, Ma X, Zhang H
Molecular cancer 2024 Mar 11;23(1):53
Molecular cancer 2024 Mar 11;23(1):53
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Tumorous IRE1α facilitates CD8(+)T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma.
Yang Y, Wang S, Wang XX, Guo S, Wang H, Shi Q, Tian Y, Wang H, Zhao T, Zhang H, Zhang B, Gao T, Li C, Yi X, Guo W
Cell communication and signaling : CCS 2024 Jan 30;22(1):83
Cell communication and signaling : CCS 2024 Jan 30;22(1):83
Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.
Wang H, Zhou Z, Zhang J, Hao T, Wang P, Wu P, Su R, Yang H, Deng G, Chen S, Gu L, He Y, Zeng L, Zhang C, Yin S
Cancer letters 2024 Jan 28;581:216498
Cancer letters 2024 Jan 28;581:216498
Sulforaphane impaired immune checkpoint blockade therapy through activating ΔNP63α/PD-L1 axis in gastric cancer.
Zhang Q, Yang C, Ma Z, Ye L, Wu Y, Zhong C, Shi Y, Zhu M
Molecular carcinogenesis 2024 Aug;63(8):1611-1620
Molecular carcinogenesis 2024 Aug;63(8):1611-1620
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020
Cancer letters 2024 Aug 1;596:217020
The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.
Ge W, Meng L, Cao S, Hou C, Zhu X, Huang D, Li Q, Peng Y, Jiang K
Journal of immunology research 2023;2023:6891636
Journal of immunology research 2023;2023:6891636
Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel.
Dai X, Zhang J, Bao X, Guo Y, Jin Y, Yang C, Zhang H, Liu L, Gao Y, Ye C, Wu W, Liu C, Zhao CX, Sheng J, Ren E, Li H, Fang W, Wu B, Ruan J, Gu Z, Chen D, Zhao P
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2303542
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2303542
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Zhang Y, Cai X, Wang B, Zhang B, Xu Y
Molecular immunology 2023 Sep;161:82-90
Molecular immunology 2023 Sep;161:82-90
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
Xu T, Dai J, Tang L, Sun L, Si L, Guo J
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
A novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in triple negative breast cancer.
Zhang J, Zhang M, Tian Q, Yang J
Clinical and experimental medicine 2023 Nov;23(7):3867-3881
Clinical and experimental medicine 2023 Nov;23(7):3867-3881
Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.
Yin J, Zhao Z, Huang J, Xiao Y, Rehmutulla M, Zhang B, Zhang Z, Xiang M, Tong Q, Zhang Y
Cell discovery 2023 Jul 25;9(1):77
Cell discovery 2023 Jul 25;9(1):77
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Song A, Ding T, Wei N, Yang J, Ma M, Zheng S, Jin H
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Exploring the effect of polyamines on NK cell function in colorectal cancer process based on glycolysis.
He H, Song Z, Lin S, Wang Y, Wang G
International immunopharmacology 2023 Apr;117:109944
International immunopharmacology 2023 Apr;117:109944
Reforming the Chimeric Antigen Receptor by Peptide Towards Optimized CAR T Cells With Enhanced Anti-Cancer Potency and Safety.
Liu C, Li L, Gao F, Zhou J, Qin Y, Yuan X, Yang G, Zhu Y
Frontiers in bioengineering and biotechnology 2022;10:928169
Frontiers in bioengineering and biotechnology 2022;10:928169
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
Guo H, Zhang W, Wang L, Shao Z, Huang X
Biomaterials 2022 Nov;290:121821
Biomaterials 2022 Nov;290:121821
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
Lu Y, Wu F, Cao Q, Sun Y, Huang M, Xiao J, Zhou B, Zhang L
Oncogene 2022 Jan;41(5):704-717
Oncogene 2022 Jan;41(5):704-717
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150
Frontiers in cellular and infection microbiology 2021;11:587150
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Yuan Q, Liang Q, Sun Z, Yuan X, Hou W, Wang Y, Wang H, Yu M
Oncoimmunology 2021;10(1):1914954
Oncoimmunology 2021;10(1):1914954
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F
Clinical and translational medicine 2021 Sep;11(9):e464
Clinical and translational medicine 2021 Sep;11(9):e464
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
Xu L, Cai P, Li X, Wu X, Gao J, Liu W, Yang J, Xu Q, Guo W, Gu Y
Toxicology and applied pharmacology 2021 Oct 1;428:115672
Toxicology and applied pharmacology 2021 Oct 1;428:115672
In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE).
Wei PS, Chen YJ, Lin SY, Chuang KH, Sheu MT, Ho HO
Biomaterials 2021 Nov;278:121166
Biomaterials 2021 Nov;278:121166
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Zhang J, Wang L, Xu X, Li X, Guan W, Meng T, Xu G
Frontiers in oncology 2020;10:1787
Frontiers in oncology 2020;10:1787
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.
Cai X, Wei B, Li L, Chen X, Liu W, Cui J, Lin Y, Sun Y, Xu Q, Guo W, Gu Y
International immunopharmacology 2020 Nov;88:106858
International immunopharmacology 2020 Nov;88:106858
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Wang X, Liang C, Xia W, Guo C, Niu Z, Zhu W, Zhang H
Molecular immunology 2020 Dec;128:41-46
Molecular immunology 2020 Dec;128:41-46
Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy.
Li C, Zhang N, Zhou J, Ding C, Jin Y, Cui X, Pu K, Zhu Y
Cancer immunology research 2018 Feb;6(2):178-188
Cancer immunology research 2018 Feb;6(2):178-188
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.
Zheng B, Ren T, Huang Y, Sun K, Wang S, Bao X, Liu K, Guo W
Journal of hematology & oncology 2018 Feb 6;11(1):16
Journal of hematology & oncology 2018 Feb 6;11(1):16
Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features.
Cho YT, Lin JW, Chen YC, Chang CY, Hsiao CH, Chung WH, Chu CY
Journal of the American Academy of Dermatology 2014 Mar;70(3):539-48
Journal of the American Academy of Dermatology 2014 Mar;70(3):539-48
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.
Li P, Zheng G, Yang Y, Zhang C, Xiong P, Xu Y, Fang M, Tan Z, Zheng F, Gong F
Cellular and molecular life sciences : CMLS 2010 Sep;67(18):3197-208
Cellular and molecular life sciences : CMLS 2010 Sep;67(18):3197-208
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 13588-1-AP(GZMB antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of Hela cells, using GZMB antibody 13588-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13588-1-AP(GZMB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13588-1-AP(GZMB antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue