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antibody from Invitrogen Antibodies
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
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- Antigen structure
- References [23]
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- Product number
- GRB05 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Granzyme B Monoclonal Antibody (GB11), APC
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- GB11
- Vial size
- 500 µL
- Storage
- 4° C
Submitted references Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation.
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression.
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8(+) T-Cell-Driven Antitumor Immunity.
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes.
Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice.
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Characterization of the early inflammatory infiltrate at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites.
Broadening the repertoire of functional herpes simplex virus type 1-specific CD8+ T cells reduces viral reactivation from latency in sensory ganglia.
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
Yeku OO, Rao TD, Laster I, Kononenko A, Purdon TJ, Wang P, Cui Z, Liu H, Brentjens RJ, Spriggs D
Frontiers in immunology 2021;12:663379
Frontiers in immunology 2021;12:663379
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC
Nature communications 2021 Oct 28;12(1):6228
Nature communications 2021 Oct 28;12(1):6228
Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation.
Kawashima K, Isogawa M, Onishi M, Baudi I, Saito S, Nakajima A, Fujita T, Tanaka Y
JCI insight 2021 Feb 8;6(3)
JCI insight 2021 Feb 8;6(3)
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
Kim EH, Woodruff MC, Grigoryan L, Maier B, Lee SH, Mandal P, Cortese M, Natrajan MS, Ravindran R, Ma H, Merad M, Gitlin AD, Mocarski ES, Jacob J, Pulendran B
eLife 2020 Jun 9;9
eLife 2020 Jun 9;9
A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression.
Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ
Nature communications 2019 Feb 15;10(1):794
Nature communications 2019 Feb 15;10(1):794
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C
Aging cell 2019 Aug;18(4):e12971
Aging cell 2019 Aug;18(4):e12971
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8(+) T-Cell-Driven Antitumor Immunity.
Buchan SL, Fallatah M, Thirdborough SM, Taraban VY, Rogel A, Thomas LJ, Penfold CA, He LZ, Curran MA, Keler T, Al-Shamkhani A
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 May 15;24(10):2383-2394
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 May 15;24(10):2383-2394
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
Zamarin D, Ricca JM, Sadekova S, Oseledchyk A, Yu Y, Blumenschein WM, Wong J, Gigoux M, Merghoub T, Wolchok JD
The Journal of clinical investigation 2018 Apr 2;128(4):1413-1428
The Journal of clinical investigation 2018 Apr 2;128(4):1413-1428
Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes.
Winkler CW, Myers LM, Woods TA, Messer RJ, Carmody AB, McNally KL, Scott DP, Hasenkrug KJ, Best SM, Peterson KE
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3526-3535
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3526-3535
Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice.
Winkler CW, Myers LM, Woods TA, Carmody AB, Taylor KG, Peterson KE
Journal of neuroinflammation 2017 Mar 24;14(1):62
Journal of neuroinflammation 2017 Mar 24;14(1):62
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Zamarin D, Holmgaard RB, Ricca J, Plitt T, Palese P, Sharma P, Merghoub T, Wolchok JD, Allison JP
Nature communications 2017 Feb 13;8:14340
Nature communications 2017 Feb 13;8:14340
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, Sivakumaran S, Ghorashian S, Carpenter B, Bennett C, Freeman GJ, Sykes M, Croft M, Al-Shamkhani A, Chakraverty R
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):125-133
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):125-133
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM
Nature immunology 2015 Aug;16(8):871-9
Nature immunology 2015 Aug;16(8):871-9
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Liechtenstein T, Perez-Janices N, Blanco-Luquin I, Goyvaerts C, Schwarze J, Dufait I, Lanna A, Ridder M, Guerrero-Setas D, Breckpot K, Escors D
Oncoimmunology 2014;3(7):e945378
Oncoimmunology 2014;3(7):e945378
Characterization of the early inflammatory infiltrate at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites.
Teixeira C, Gomes R, Oliveira F, Meneses C, Gilmore DC, Elnaiem DE, Valenzuela JG, Kamhawi S
PLoS neglected tropical diseases 2014 Apr;8(4):e2781
PLoS neglected tropical diseases 2014 Apr;8(4):e2781
Broadening the repertoire of functional herpes simplex virus type 1-specific CD8+ T cells reduces viral reactivation from latency in sensory ganglia.
St Leger AJ, Jeon S, Hendricks RL
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2258-65
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2258-65
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.
Lemaître F, Moreau HD, Vedele L, Bousso P
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 15;191(4):1578-85
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 15;191(4):1578-85
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Deguine J, Breart B, Lemaître F, Bousso P
Journal of immunology (Baltimore, Md. : 1950) 2012 Dec 15;189(12):5493-7
Journal of immunology (Baltimore, Md. : 1950) 2012 Dec 15;189(12):5493-7
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
Randall KL, Chan SS, Ma CS, Fung I, Mei Y, Yabas M, Tan A, Arkwright PD, Al Suwairi W, Lugo Reyes SO, Yamazaki-Nakashimada MA, Garcia-Cruz Mde L, Smart JM, Picard C, Okada S, Jouanguy E, Casanova JL, Lambe T, Cornall RJ, Russell S, Oliaro J, Tangye SG, Bertram EM, Goodnow CC
The Journal of experimental medicine 2011 Oct 24;208(11):2305-20
The Journal of experimental medicine 2011 Oct 24;208(11):2305-20
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, Berzins SP, Smyth MJ, Godfrey DI
Journal of immunology (Baltimore, Md. : 1950) 2007 Mar 1;178(5):2827-34
Journal of immunology (Baltimore, Md. : 1950) 2007 Mar 1;178(5):2827-34
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, Berzins SP, Smyth MJ, Godfrey DI
Journal of immunology (Baltimore, Md. : 1950) 2007 Mar 1;178(5):2827-34
Journal of immunology (Baltimore, Md. : 1950) 2007 Mar 1;178(5):2827-34
CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A
Circulation research 2007 Aug 3;101(3):248-57
Circulation research 2007 Aug 3;101(3):248-57
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
Matsuda JL, Zhang Q, Ndonye R, Richardson SK, Howell AR, Gapin L
Blood 2006 Apr 1;107(7):2797-805
Blood 2006 Apr 1;107(7):2797-805
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- Figure 5 Intrahepatic activation of type I IFN response induces functional differentiation of HBV-specific CD8 + T cells and facilitates HBV clearance. ( A ) Schematic representation of the experiment (NaCl [day 7]; n = 3, PIC-LNP [day 7]; n = 5, NaCl [day 14]; n = 7, PIC-LNP [day 14]; n = 7). ( B ) The number of COR93-specific CD8 + T cells in the liver as well as their in vitro IFN-gamma-producing ability and ex vivo granzyme B expression were analyzed by FACS. ( C ) Serum alanine aminotransferase (ALT) levels on days 0, 7, and 14 after transfer. ( D ) HBV mRNA expression in the liver analyzed by Northern blotting (left panel; representative samples) and RT-qPCR (right panel). ( E ) The mRNA expression levels of ISGs in COR93-specific CD8 + T cells purified from the liver of HBV-Tg mice on day 4 after PIC-LNP or NaCl treatment ( n = 2 for each group). Results are representative of 3 independent experiments. Data represent mean +- SD ( n >= 3). P values determined by Student's t test (1 sided, unpaired). * P < 0.05, ** P < 0.01, *** P < 0.001.
