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LearnMHGB04
antibody from Invitrogen Antibodies
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Flow cytometry
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- Antibody Data
- Antigen structure
- References [72]
- Comments [0]
- Validations
- Other assay [2]
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- Product number
- MHGB04 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Granzyme B Monoclonal Antibody (GB12), PE
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- According to the literature this antibody recognizes granzyme B1 . Each lot is tested by flow cytometry using peripheral blood leukocytes. Based on this testing it is recommended that 5 µL of antibody be used per 1 x 10^6 cells. For R-PE conjugates excitation 488 nm/peak emission 575 nm. Matching isotype control is available: Ms IgG1 R-PE #MG104.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Antibody clone number
- GB12
- Vial size
- 500 µL
- Concentration
- 0.15 mg/mL
- Storage
- 4° C
Submitted references MYB orchestrates T cell exhaustion and response to checkpoint inhibition.
Lymph node-resident dendritic cells drive T(H)2 cell development involving MARCH1.
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19(+)HLA-C1(-) Malignant B Cells While Sparing CD19(+)HLA-C1(+) Healthy B Cells.
Early precursor T cells establish and propagate T cell exhaustion in chronic infection.
Developmental Relationships of Four Exhausted CD8(+) T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection.
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
miR-150-Mediated Foxo1 Regulation Programs CD8(+) T Cell Differentiation.
IL-10-Engineered Human CD4(+) Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism.
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells.
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.
Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.
Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.
CTLA-4 (CD152) enhances the Tc17 differentiation program.
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.
Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function.
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.
Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses.
High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology.
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Granzyme B regulates antiviral CD8+ T cell responses.
Impact of age, gender, and race on circulating γδ T cells.
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro.
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS.
Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques.
CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation.
Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes.
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Activated CD4+CD25+ T cells selectively kill B lymphocytes.
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection.
Extensive flow cytometric characterization of plasmacytoid dendritic cell leukemia cells.
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.
Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Human neutrophils lack granzyme A, granzyme B, and perforin.
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells.
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, Utzschneider DT, Nüssing S, Liao Y, Mason T, Torres SV, Wilcox SA, Kanev K, Jarosch S, Leube J, Nutt SL, Zehn D, Parish IA, Kastenmüller W, Shi W, Buchholz VR, Kallies A
Nature 2022 Sep;609(7926):354-360
Nature 2022 Sep;609(7926):354-360
Lymph node-resident dendritic cells drive T(H)2 cell development involving MARCH1.
Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS
Science immunology 2021 Oct 15;6(64):eabh0707
Science immunology 2021 Oct 15;6(64):eabh0707
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Bonilla WV, Kirchhammer N, Marx AF, Kallert SM, Krzyzaniak MA, Lu M, Darbre S, Schmidt S, Raguz J, Berka U, Vincenti I, Pauzuolis M, Kerber R, Hoepner S, Günther S, Magnus C, Merkler D, Orlinger KK, Zippelius A, Pinschewer DD
Cell reports. Medicine 2021 Mar 16;2(3):100209
Cell reports. Medicine 2021 Mar 16;2(3):100209
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Marinaik CB, Kingstad-Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, Neldner B, Gasper DJ, Kedl RM, Kawaoka Y, Suresh M
Cell reports. Medicine 2020 Sep 22;1(6):100095
Cell reports. Medicine 2020 Sep 22;1(6):100095
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19(+)HLA-C1(-) Malignant B Cells While Sparing CD19(+)HLA-C1(+) Healthy B Cells.
Tao L, Farooq MA, Gao Y, Zhang L, Niu C, Ajmal I, Zhou Y, He C, Zhao G, Yao J, Liu M, Jiang W
Cancers 2020 Sep 13;12(9)
Cancers 2020 Sep 13;12(9)
Early precursor T cells establish and propagate T cell exhaustion in chronic infection.
Utzschneider DT, Gabriel SS, Chisanga D, Gloury R, Gubser PM, Vasanthakumar A, Shi W, Kallies A
Nature immunology 2020 Oct;21(10):1256-1266
Nature immunology 2020 Oct;21(10):1256-1266
Developmental Relationships of Four Exhausted CD8(+) T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ
Immunity 2020 May 19;52(5):825-841.e8
Immunity 2020 May 19;52(5):825-841.e8
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Sandu I, Cerletti D, Oetiker N, Borsa M, Wagen F, Spadafora I, Welten SPM, Stolz U, Oxenius A, Claassen M
Cell reports 2020 Aug 25;32(8):108078
Cell reports 2020 Aug 25;32(8):108078
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
Lin W, Xu D, Austin CD, Caplazi P, Senger K, Sun Y, Jeet S, Young J, Delarosa D, Suto E, Huang Z, Zhang J, Yan D, Corzo C, Barck K, Rajan S, Looney C, Gandham V, Lesch J, Liang WC, Mai E, Ngu H, Ratti N, Chen Y, Misner D, Lin T, Danilenko D, Katavolos P, Doudemont E, Uppal H, Eastham J, Mak J, de Almeida PE, Bao K, Hadadianpour A, Keir M, Carano RAD, Diehl L, Xu M, Wu Y, Weimer RM, DeVoss J, Lee WP, Balazs M, Walsh K, Alatsis KR, Martin F, Zarrin AA
Frontiers in immunology 2019;10:2019
Frontiers in immunology 2019;10:2019
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B
Cell 2019 Feb 21;176(5):967-981.e19
Cell 2019 Feb 21;176(5):967-981.e19
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Hu X, Lu Z, Valentin A, Rosati M, Broderick KE, Sardesai NY, Marx PA, Mullins JI, Pavlakis GN, Felber BK
Human vaccines & immunotherapeutics 2018;14(9):2163-2177
Human vaccines & immunotherapeutics 2018;14(9):2163-2177
Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.
Jensen IJ, Winborn CS, Fosdick MG, Shao P, Tremblay MM, Shan Q, Tripathy SK, Snyder CM, Xue HH, Griffith TS, Houtman JC, Badovinac VP
PLoS pathogens 2018 Oct;14(10):e1007405
PLoS pathogens 2018 Oct;14(10):e1007405
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection.
Harker JA, Wong KA, Dallari S, Bao P, Dolgoter A, Jo Y, Wehrens EJ, Macal M, Zuniga EI
Journal of virology 2018 Jun 15;92(12)
Journal of virology 2018 Jun 15;92(12)
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
Danahy DB, Anthony SM, Jensen IJ, Hartwig SM, Shan Q, Xue HH, Harty JT, Griffith TS, Badovinac VP
PLoS pathogens 2017 Sep;13(9):e1006569
PLoS pathogens 2017 Sep;13(9):e1006569
miR-150-Mediated Foxo1 Regulation Programs CD8(+) T Cell Differentiation.
Ban YH, Oh SC, Seo SH, Kim SM, Choi IP, Greenberg PD, Chang J, Kim TD, Ha SJ
Cell reports 2017 Sep 12;20(11):2598-2611
Cell reports 2017 Sep 12;20(11):2598-2611
IL-10-Engineered Human CD4(+) Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism.
Locafaro G, Andolfi G, Russo F, Cesana L, Spinelli A, Camisa B, Ciceri F, Lombardo A, Bondanza A, Roncarolo MG, Gregori S
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Oct 4;25(10):2254-2269
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Oct 4;25(10):2254-2269
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Dolina JS, Cechova S, Rudy CK, Sung SJ, Tang WW, Lee J, Hahn YS, Le TH
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2341-2351
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2341-2351
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ
Journal for immunotherapy of cancer 2017 Dec 19;5(1):98
Journal for immunotherapy of cancer 2017 Dec 19;5(1):98
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells.
Marafini I, Monteleone I, Di Fusco D, Sedda S, Cupi ML, Fina D, Paoluzi AO, Pallone F, Monteleone G
PloS one 2016;11(5):e0155103
PloS one 2016;11(5):e0155103
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Hu X, Valentin A, Dayton F, Kulkarni V, Alicea C, Rosati M, Chowdhury B, Gautam R, Broderick KE, Sardesai NY, Martin MA, Mullins JI, Pavlakis GN, Felber BK
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 15;197(10):3999-4013
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 15;197(10):3999-4013
Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.
Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy RS, Kissick HT, Nayak K, Reddy ES, Kalam H, Kumar D, Verma A, Panda H, Wang S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Medigeshi GR, Lodha R, Kabra S, Ahmed R, Murali-Krishna K
Journal of virology 2016 Dec 15;90(24):11259-11278
Journal of virology 2016 Dec 15;90(24):11259-11278
Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.
Martins MA, Tully DC, Cruz MA, Power KA, Veloso de Santana MG, Bean DJ, Ogilvie CB, Gadgil R, Lima NS, Magnani DM, Ejima K, Allison DB, Piatak M Jr, Altman JD, Parks CL, Rakasz EG, Capuano S 3rd, Galler R, Bonaldo MC, Lifson JD, Allen TM, Watkins DI
Journal of virology 2015 Nov;89(21):10802-20
Journal of virology 2015 Nov;89(21):10802-20
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, Reader B, Mo X, Cheney C, Briercheck E, Vasilakos JP, Dietsch GN, Hershberg RM, Caligiuri M, Byrd JC, Butchar JP, Tridandapani S
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2786-95
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2786-95
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.
Hu Z, Blackman MA, Kaye KM, Usherwood EJ
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2746-56
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2746-56
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
Kulkarni V, Valentin A, Rosati M, Alicea C, Singh AK, Jalah R, Broderick KE, Sardesai NY, Le Gall S, Mothe B, Brander C, Rolland M, Mullins JI, Pavlakis GN, Felber BK
PloS one 2014;9(1):e86254
PloS one 2014;9(1):e86254
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.
Ntranos A, Hall O, Robinson DP, Grishkan IV, Schott JT, Tosi DM, Klein SL, Calabresi PA, Gocke AR
Journal of neuroimmunology 2014 May 15;270(1-2):13-21
Journal of neuroimmunology 2014 May 15;270(1-2):13-21
Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.
Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Rénia L, Ruedl C, MacDonald KP, Hill GR, Engwerda CR
The Journal of clinical investigation 2014 Jun;124(6):2483-96
The Journal of clinical investigation 2014 Jun;124(6):2483-96
CTLA-4 (CD152) enhances the Tc17 differentiation program.
Pick J, Arra A, Lingel H, Hegel JK, Huber M, Nishanth G, Jorch G, Fischer KD, Schlüter D, Tedford K, Brunner-Weinzierl MC
European journal of immunology 2014 Jul;44(7):2139-52
European journal of immunology 2014 Jul;44(7):2139-52
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.
Hagn M, Blackwell SE, Beyer T, Ebel V, Fabricius D, Lindner S, Stilgenbauer S, Simmet T, Tam C, Neeson P, Trapani JA, Schrezenmeier H, Weiner GJ, Jahrsdörfer B
International immunology 2014 Jul;26(7):383-95
International immunology 2014 Jul;26(7):383-95
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R
The Journal of experimental medicine 2014 Aug 25;211(9):1905-18
The Journal of experimental medicine 2014 Aug 25;211(9):1905-18
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
Mellor-Heineke S, Villanueva J, Jordan MB, Marsh R, Zhang K, Bleesing JJ, Filipovich AH, Risma KA
Frontiers in immunology 2013;4:72
Frontiers in immunology 2013;4:72
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.
Olson JA, McDonald-Hyman C, Jameson SC, Hamilton SE
Immunity 2013 Jun 27;38(6):1250-60
Immunity 2013 Jun 27;38(6):1250-60
Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
Penaloza-MacMaster P, Provine NM, Ra J, Borducchi EN, McNally A, Simmons NL, Iampietro MJ, Barouch DH
Journal of virology 2013 Feb;87(3):1373-84
Journal of virology 2013 Feb;87(3):1373-84
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
Jalah R, Patel V, Kulkarni V, Rosati M, Alicea C, Ganneru B, von Gegerfelt A, Huang W, Guan Y, Broderick KE, Sardesai NY, LaBranche C, Montefiori DC, Pavlakis GN, Felber BK
Human vaccines & immunotherapeutics 2012 Nov 1;8(11):1620-9
Human vaccines & immunotherapeutics 2012 Nov 1;8(11):1620-9
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
D'Eliseo D, Manzi L, Merendino N, Velotti F
The Journal of nutritional biochemistry 2012 May;23(5):452-7
The Journal of nutritional biochemistry 2012 May;23(5):452-7
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB
Cell host & microbe 2012 Jun 14;11(6):643-53
Cell host & microbe 2012 Jun 14;11(6):643-53
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Altin JA, Goodnow CC, Cook MC
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5478-88
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5478-88
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Hersperger AR, Siciliano NA, Eisenlohr LC
Journal of virology 2012 Jul;86(13):7298-309
Journal of virology 2012 Jul;86(13):7298-309
Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function.
Desmarets M, Mylvaganam G, Waller EK, Josephson CD, Pack C, Lukacher AE, Zimring JC
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Sep;11(9):1825-34
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Sep;11(9):1825-34
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.
Hsieh SH, Lin JS, Huang JH, Wu SY, Chu CL, Kung JT, Wu-Hsieh BA
Infection and immunity 2011 Nov;79(11):4493-502
Infection and immunity 2011 Nov;79(11):4493-502
Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses.
Mahnke YD, Saqr A, Hazenfeld S, Brady RC, Roederer M, Subbramanian RA
Vaccine 2011 Nov 3;29(47):8606-14
Vaccine 2011 Nov 3;29(47):8606-14
High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology.
Haque A, Best SE, Amante FH, Ammerdorffer A, de Labastida F, Pereira T, Ramm GA, Engwerda CR
Infection and immunity 2011 May;79(5):1882-8
Infection and immunity 2011 May;79(5):1882-8
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Kallies A, Carotta S, Huntington ND, Bernard NJ, Tarlinton DM, Smyth MJ, Nutt SL
Blood 2011 Feb 10;117(6):1869-79
Blood 2011 Feb 10;117(6):1869-79
Granzyme B regulates antiviral CD8+ T cell responses.
Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6301-9
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6301-9
Impact of age, gender, and race on circulating γδ T cells.
Cairo C, Armstrong CL, Cummings JS, Deetz CO, Tan M, Lu C, Davis CE, Pauza CD
Human immunology 2010 Oct;71(10):968-75
Human immunology 2010 Oct;71(10):968-75
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T
Cancer research 2010 Oct 15;70(20):7788-99
Cancer research 2010 Oct 15;70(20):7788-99
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S
The Journal of experimental medicine 2010 Nov 22;207(12):2561-8
The Journal of experimental medicine 2010 Nov 22;207(12):2561-8
CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
Reeves RK, Gillis J, Wong FE, Yu Y, Connole M, Johnson RP
Blood 2010 Jun 3;115(22):4439-46
Blood 2010 Jun 3;115(22):4439-46
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.
Ribeiro de Almeida C, Heath H, Krpic S, Dingjan GM, van Hamburg JP, Bergen I, van de Nobelen S, Sleutels F, Grosveld F, Galjart N, Hendriks RW
Journal of immunology (Baltimore, Md. : 1950) 2009 Jan 15;182(2):999-1010
Journal of immunology (Baltimore, Md. : 1950) 2009 Jan 15;182(2):999-1010
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, Syrovets T, Laumonnier Y, Fabricius D, Simmet T, Jahrsdörfer B
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1838-45
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1838-45
Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro.
Wagner C, Stegmaier S, Hänsch GM
Molecular immunology 2008 Mar;45(6):1761-6
Molecular immunology 2008 Mar;45(6):1761-6
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Chiarle R, Martinengo C, Mastini C, Ambrogio C, D'Escamard V, Forni G, Inghirami G
Nature medicine 2008 Jun;14(6):676-80
Nature medicine 2008 Jun;14(6):676-80
Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS.
Cummings JS, Cairo C, Armstrong C, Davis CE, Pauza CD
Journal of leukocyte biology 2008 Aug;84(2):371-9
Journal of leukocyte biology 2008 Aug;84(2):371-9
Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.
Sridhar S, Reyes-Sandoval A, Draper SJ, Moore AC, Gilbert SC, Gao GP, Wilson JM, Hill AV
Journal of virology 2008 Apr;82(8):3822-33
Journal of virology 2008 Apr;82(8):3822-33
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
Tao J, Gao Y, Li MO, He W, Chen L, Harvev B, Davis RJ, Flavell RA, Yin Z
European journal of immunology 2007 Mar;37(3):818-29
European journal of immunology 2007 Mar;37(3):818-29
Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques.
Chan KS, Kaur A
Journal of immunological methods 2007 Aug 31;325(1-2):20-34
Journal of immunological methods 2007 Aug 31;325(1-2):20-34
CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation.
Romagnani C, Juelke K, Falco M, Morandi B, D'Agostino A, Costa R, Ratto G, Forte G, Carrega P, Lui G, Conte R, Strowig T, Moretta A, Münz C, Thiel A, Moretta L, Ferlazzo G
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):4947-55
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):4947-55
Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes.
Macchia I, Gauduin MC, Kaur A, Johnson RP
Immunology 2006 Oct;119(2):232-42
Immunology 2006 Oct;119(2):232-42
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM
Cancer research 2006 Oct 15;66(20):10145-52
Cancer research 2006 Oct 15;66(20):10145-52
Activated CD4+CD25+ T cells selectively kill B lymphocytes.
Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM
Blood 2006 May 15;107(10):3925-32
Blood 2006 May 15;107(10):3925-32
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA
Molecular immunology 2006 Mar;43(8):1129-43
Molecular immunology 2006 Mar;43(8):1129-43
Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection.
McIlroy D, Meyer L, Dudoit Y, Samri A, Delfraissy JF, Autran B, Debré P, Theodorou I
International journal of immunogenetics 2006 Apr;33(2):73-9
International journal of immunogenetics 2006 Apr;33(2):73-9
Extensive flow cytometric characterization of plasmacytoid dendritic cell leukemia cells.
Gopcsa L, Banyai A, Jakab K, Kormos L, Tamaska J, Matolcsy A, Gogolak P, Rajnavolgyi E, Paloczi K
European journal of haematology 2005 Oct;75(4):346-51
European journal of haematology 2005 Oct;75(4):346-51
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Lang A, Nikolich-Zugich J
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Lang A, Nikolich-Zugich J
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.
Grossman WJ, Radhi M, Schauer D, Gerday E, Grose C, Goldman FD
Blood 2005 Aug 15;106(4):1203-6
Blood 2005 Aug 15;106(4):1203-6
Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells.
Quéméneur L, Beloeil L, Michallet MC, Angelov G, Tomkowiak M, Revillard JP, Marvel J
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):4945-52
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):4945-52
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ
Blood 2004 Nov 1;104(9):2840-8
Blood 2004 Nov 1;104(9):2840-8
Human neutrophils lack granzyme A, granzyme B, and perforin.
Metkar SS, Froelich CJ
Blood 2004 Aug 1;104(3):905-6; author reply 907-8
Blood 2004 Aug 1;104(3):905-6; author reply 907-8
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
McIlroy D, Cartron PF, Tuffery P, Dudoit Y, Samri A, Autran B, Vallette FM, Debré P, Theodorou I
Proceedings of the National Academy of Sciences of the United States of America 2003 Mar 4;100(5):2562-7
Proceedings of the National Academy of Sciences of the United States of America 2003 Mar 4;100(5):2562-7
Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells.
Byers AM, Kemball CC, Moser JM, Lukacher AE
Journal of immunology (Baltimore, Md. : 1950) 2003 Jul 1;171(1):17-21
Journal of immunology (Baltimore, Md. : 1950) 2003 Jul 1;171(1):17-21
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Supportive validation
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- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Conjugate
- Yellow dye
