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LearnMHGB05
antibody from Invitrogen Antibodies
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
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- References [63]
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- Product number
- MHGB05 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Granzyme B Monoclonal Antibody (GB12), APC
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- GB12
- Vial size
- 500 µL
- Concentration
- 0.15 mg/mL
- Storage
- 4° C
Submitted references Effects of therapeutic vaccination on the control of SIV in rhesus macaques with variable responsiveness to antiretroviral drugs.
Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques.
Flow cytometry-based ex vivo murine NK cell cytotoxicity assay.
Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation.
Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy.
Heterogenous Populations of Tissue-Resident CD8(+) T Cells Are Generated in Response to Infection and Malignancy.
Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.
Senolytic CAR T cells reverse senescence-associated pathologies.
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8(+) T Cells in Murine Syngeneic Tumor Models.
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses.
Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity.
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8(+) T cells.
FOXO1 opposition of CD8(+) T cell effector programming confers early memory properties and phenotypic diversity.
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance.
MAIT cells are activated during human viral infections.
Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection.
Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.
Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection.
Type I-IFNs control GVHD and GVL responses after transplantation.
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.
Impact of age, gender, and race on circulating γδ T cells.
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys.
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response.
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.
The level of friend retrovirus replication determines the cytolytic pathway of CD8+ T-cell-mediated pathogen control.
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Tunggal HC, Munson PV, O'Connor MA, Hajari N, Dross SE, Bratt D, Fuller JT, Bagley K, Fuller DH
PloS one 2021;16(6):e0253265
PloS one 2021;16(6):e0253265
Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques.
Rosati M, Agarwal M, Hu X, Devasundaram S, Stellas D, Chowdhury B, Bear J, Burns R, Donohue D, Pessaint L, Andersen H, Lewis MG, Terpos E, Dimopoulos MA, Wlodawer A, Mullins JI, Venzon DJ, Pavlakis GN, Felber BK
PLoS pathogens 2021 Sep;17(9):e1009701
PLoS pathogens 2021 Sep;17(9):e1009701
Flow cytometry-based ex vivo murine NK cell cytotoxicity assay.
Wong P, Wagner JA, Berrien-Elliott MM, Schappe T, Fehniger TA
STAR protocols 2021 Mar 19;2(1):100262
STAR protocols 2021 Mar 19;2(1):100262
Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation.
Carter TJ, Agliardi G, Lin FY, Ellis M, Jones C, Robson M, Richard-Londt A, Southern P, Lythgoe M, Zaw Thin M, Ryzhov V, de Rosales RTM, Gruettner C, Abdollah MRA, Pedley RB, Pankhurst QA, Kalber TL, Brandner S, Quezada S, Mulholland P, Shevtsov M, Chester K
Small (Weinheim an der Bergstrasse, Germany) 2021 Apr;17(14):e2005241
Small (Weinheim an der Bergstrasse, Germany) 2021 Apr;17(14):e2005241
Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy.
Cubas R, Khan Z, Gong Q, Moskalenko M, Xiong H, Ou Q, Pai C, Rodriguez R, Cheung J, Chan AC
Journal for immunotherapy of cancer 2020 Oct;8(2)
Journal for immunotherapy of cancer 2020 Oct;8(2)
Heterogenous Populations of Tissue-Resident CD8(+) T Cells Are Generated in Response to Infection and Malignancy.
Milner JJ, Toma C, He Z, Kurd NS, Nguyen QP, McDonald B, Quezada L, Widjaja CE, Witherden DA, Crowl JT, Shaw LA, Yeo GW, Chang JT, Omilusik KD, Goldrath AW
Immunity 2020 May 19;52(5):808-824.e7
Immunity 2020 May 19;52(5):808-824.e7
Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.
Felber BK, Lu Z, Hu X, Valentin A, Rosati M, Remmel CAL, Weiner JA, Carpenter MC, Faircloth K, Stanfield-Oakley S, Williams WB, Shen X, Tomaras GD, LaBranche CC, Montefiori D, Trinh HV, Rao M, Alam MS, Vandergrift NA, Saunders KO, Wang Y, Rountree W, Das J, Alter G, Reed SG, Aye PP, Schiro F, Pahar B, Dufour JP, Veazey RS, Marx PA, Venzon DJ, Shaw GM, Ferrari G, Ackerman ME, Haynes BF, Pavlakis GN
Cell reports 2020 May 12;31(6):107624
Cell reports 2020 May 12;31(6):107624
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.
Wagner JA, Wong P, Schappe T, Berrien-Elliott MM, Cubitt C, Jaeger N, Lee M, Keppel CR, Marin ND, Foltz JA, Marsala L, Neal CC, Sullivan RP, Schneider SE, Keppel MP, Saucier N, Cooper MA, Fehniger TA
Cell reports 2020 Jun 2;31(9):107720
Cell reports 2020 Jun 2;31(9):107720
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW
Nature 2020 Jul;583(7814):127-132
Nature 2020 Jul;583(7814):127-132
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
Piersma SJ, Poursine-Laurent J, Yang L, Barber GN, Parikh BA, Yokoyama WM
eLife 2020 Jul 29;9
eLife 2020 Jul 29;9
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Berrien-Elliott MM, Sun Y, Neal C, Ireland A, Trissal MC, Sullivan RP, Wagner JA, Leong JW, Wong P, Mah-Som AY, Wong TN, Schappe T, Keppel CR, Cortez VS, Stamatiades EG, Li MO, Colonna M, Link DC, French AR, Cooper MA, Wang WL, Boldin MP, Reddy P, Fehniger TA
Immunity 2019 Sep 17;51(3):479-490.e6
Immunity 2019 Sep 17;51(3):479-490.e6
Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8(+) T Cells in Murine Syngeneic Tumor Models.
Xiong H, Mittman S, Rodriguez R, Pacheco-Sanchez P, Moskalenko M, Yang Y, Elstrott J, Ritter AT, Müller S, Nickles D, Arenzana TL, Capietto AH, Delamarre L, Modrusan Z, Rutz S, Mellman I, Cubas R
Cancer immunology research 2019 Jun;7(6):963-976
Cancer immunology research 2019 Jun;7(6):963-976
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Hu X, Lu Z, Valentin A, Rosati M, Broderick KE, Sardesai NY, Marx PA, Mullins JI, Pavlakis GN, Felber BK
Human vaccines & immunotherapeutics 2018;14(9):2163-2177
Human vaccines & immunotherapeutics 2018;14(9):2163-2177
Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses.
Cubas R, Moskalenko M, Cheung J, Yang M, McNamara E, Xiong H, Hoves S, Ries CH, Kim J, Gould S
Journal of immunology (Baltimore, Md. : 1950) 2018 Oct 15;201(8):2273-2286
Journal of immunology (Baltimore, Md. : 1950) 2018 Oct 15;201(8):2273-2286
Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity.
Hatfield SD, Daniels KA, O'Donnell CL, Waggoner SN, Welsh RM
Virology 2018 Jun;519:131-144
Virology 2018 Jun;519:131-144
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8(+) T cells.
Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM
The Journal of experimental medicine 2018 Feb 5;215(2):575-594
The Journal of experimental medicine 2018 Feb 5;215(2):575-594
FOXO1 opposition of CD8(+) T cell effector programming confers early memory properties and phenotypic diversity.
Delpoux A, Lai CY, Hedrick SM, Doedens AL
Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 17;114(42):E8865-E8874
Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 17;114(42):E8865-E8874
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S
Nature communications 2017 Mar 16;8:14600
Nature communications 2017 Mar 16;8:14600
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ
Journal for immunotherapy of cancer 2017 Dec 19;5(1):98
Journal for immunotherapy of cancer 2017 Dec 19;5(1):98
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance.
Doedens AL, Rubinstein MP, Gross ET, Best JA, Craig DH, Baker MK, Cole DJ, Bui JD, Goldrath AW
Cancer immunology research 2016 Sep 2;4(9):799-811
Cancer immunology research 2016 Sep 2;4(9):799-811
MAIT cells are activated during human viral infections.
van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L, STOP-HCV consortium, Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR, Klenerman P
Nature communications 2016 Jun 23;7:11653
Nature communications 2016 Jun 23;7:11653
Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR
Transplantation 2016 Dec;100(12):2630-2639
Transplantation 2016 Dec;100(12):2630-2639
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Vogel AJ, Brown DM
Frontiers in immunology 2015;6:327
Frontiers in immunology 2015;6:327
Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection.
Sakala IG, Chaudhri G, Eldi P, Buller RM, Karupiah G
PloS one 2015;10(3):e0118685
PloS one 2015;10(3):e0118685
Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.
Mouchacca P, Chasson L, Frick M, Foray C, Schmitt-Verhulst AM, Boyer C
Immunology 2015 May;145(1):24-33
Immunology 2015 May;145(1):24-33
Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE
PLoS pathogens 2014 May;10(5):e1004134
PLoS pathogens 2014 May;10(5):e1004134
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
Sleiman M, Brons NH, Kaoma T, Dogu F, Villa-Forte A, Lenoble P, Hentges F, Kotsch K, Gadola SD, Vilches C, Zimmer J
Journal of immunology (Baltimore, Md. : 1950) 2014 Mar 15;192(6):2602-10
Journal of immunology (Baltimore, Md. : 1950) 2014 Mar 15;192(6):2602-10
The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.
Nakajima K, Maekawa Y, Kataoka K, Ishifune C, Nishida J, Arimochi H, Kitamura A, Yoshimoto T, Tomita S, Nagahiro S, Yasutomo K
Nature communications 2013;4:2112
Nature communications 2013;4:2112
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.
Durant LR, Makris S, Voorburg CM, Loebbermann J, Johansson C, Openshaw PJ
Journal of virology 2013 Oct;87(20):10946-54
Journal of virology 2013 Oct;87(20):10946-54
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW
Nature immunology 2013 Nov;14(11):1173-82
Nature immunology 2013 Nov;14(11):1173-82
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney NP, Schuijs M, O'Garra A, Johansson C, Openshaw PJ
PloS one 2012;7(2):e32371
PloS one 2012;7(2):e32371
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster KE, Sprent J, Culley FJ, Johansson C, Openshaw PJ
Mucosal immunology 2012 Mar;5(2):161-72
Mucosal immunology 2012 Mar;5(2):161-72
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP
Blood 2012 Jun 14;119(24):5898-908
Blood 2012 Jun 14;119(24):5898-908
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Altin JA, Goodnow CC, Cook MC
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5478-88
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5478-88
Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection.
Tate MD, Brooks AG, Reading PC, Mintern JD
Immunology and cell biology 2012 Feb;90(2):197-205
Immunology and cell biology 2012 Feb;90(2):197-205
Type I-IFNs control GVHD and GVL responses after transplantation.
Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, Raffelt NC, De Weerd NA, Lineburg KE, Varelias A, Markey KA, Koyama M, Clouston AD, Hertzog PJ, Macdonald KP, Hill GR
Blood 2011 Sep 22;118(12):3399-409
Blood 2011 Sep 22;118(12):3399-409
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Kallies A, Carotta S, Huntington ND, Bernard NJ, Tarlinton DM, Smyth MJ, Nutt SL
Blood 2011 Feb 10;117(6):1869-79
Blood 2011 Feb 10;117(6):1869-79
Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3348-58
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3348-58
Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.
Yuen TJ, Flesch IE, Hollett NA, Dobson BM, Russell TA, Fahrer AM, Tscharke DC
Journal of virology 2010 Oct;84(19):10220-9
Journal of virology 2010 Oct;84(19):10220-9
Impact of age, gender, and race on circulating γδ T cells.
Cairo C, Armstrong CL, Cummings JS, Deetz CO, Tan M, Lu C, Davis CE, Pauza CD
Human immunology 2010 Oct;71(10):968-75
Human immunology 2010 Oct;71(10):968-75
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T
Cancer research 2010 Oct 15;70(20):7788-99
Cancer research 2010 Oct 15;70(20):7788-99
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S
The Journal of experimental medicine 2010 Nov 22;207(12):2561-8
The Journal of experimental medicine 2010 Nov 22;207(12):2561-8
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I
Blood 2010 Nov 11;116(19):3818-27
Blood 2010 Nov 11;116(19):3818-27
Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys.
Rout N, Else JG, Yue S, Connole M, Exley MA, Kaur A
Journal of medical primatology 2010 Aug;39(4):224-34
Journal of medical primatology 2010 Aug;39(4):224-34
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Tait ED, Jordan KA, Dupont CD, Harris TH, Gregg B, Wilson EH, Pepper M, Dzierszinski F, Roos DS, Hunter CA
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 1;185(3):1502-12
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 1;185(3):1502-12
The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response.
Zelinskyy G, Dietze KK, Hüsecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U
Blood 2009 Oct 8;114(15):3199-207
Blood 2009 Oct 8;114(15):3199-207
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Moffat JM, Gebhardt T, Doherty PC, Turner SJ, Mintern JD
European journal of immunology 2009 May;39(5):1203-10
European journal of immunology 2009 May;39(5):1203-10
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, Syrovets T, Laumonnier Y, Fabricius D, Simmet T, Jahrsdörfer B
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1838-45
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1838-45
Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells.
Jenkins MR, Mintern J, La Gruta NL, Kedzierska K, Doherty PC, Turner SJ
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3818-22
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3818-22
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.
Sridhar S, Reyes-Sandoval A, Draper SJ, Moore AC, Gilbert SC, Gao GP, Wilson JM, Hill AV
Journal of virology 2008 Apr;82(8):3822-33
Journal of virology 2008 Apr;82(8):3822-33
The level of friend retrovirus replication determines the cytolytic pathway of CD8+ T-cell-mediated pathogen control.
Zelinskyy G, Balkow S, Schimmer S, Werner T, Simon MM, Dittmer U
Journal of virology 2007 Nov;81(21):11881-90
Journal of virology 2007 Nov;81(21):11881-90
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.
Jenkins MR, Kedzierska K, Doherty PC, Turner SJ
Journal of immunology (Baltimore, Md. : 1950) 2007 Jul 1;179(1):64-70
Journal of immunology (Baltimore, Md. : 1950) 2007 Jul 1;179(1):64-70
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM
Cancer research 2006 Oct 15;66(20):10145-52
Cancer research 2006 Oct 15;66(20):10145-52
Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.
Irwin SM, Izzo AA, Dow SW, Skeiky YA, Reed SG, Alderson MR, Orme IM
Infection and immunity 2005 Sep;73(9):5809-16
Infection and immunity 2005 Sep;73(9):5809-16
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
Bratke K, Kuepper M, Bade B, Virchow JC Jr, Luttmann W
European journal of immunology 2005 Sep;35(9):2608-16
European journal of immunology 2005 Sep;35(9):2608-16
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Lang A, Nikolich-Zugich J
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Lang A, Nikolich-Zugich J
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 1;174(5):2919-25
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.
Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ
Journal of immunology (Baltimore, Md. : 1950) 2005 Feb 15;174(4):1783-6
Journal of immunology (Baltimore, Md. : 1950) 2005 Feb 15;174(4):1783-6
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Zelinskyy G, Robertson SJ, Schimmer S, Messer RJ, Hasenkrug KJ, Dittmer U
Journal of virology 2005 Aug;79(16):10619-26
Journal of virology 2005 Aug;79(16):10619-26
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.
Grossman WJ, Radhi M, Schauer D, Gerday E, Grose C, Goldman FD
Blood 2005 Aug 15;106(4):1203-6
Blood 2005 Aug 15;106(4):1203-6
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ
Blood 2004 Nov 1;104(9):2840-8
Blood 2004 Nov 1;104(9):2840-8
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- Figure 5 CpG immunization and IAV infection induce effector T cell responses in the lung . BALB/cByJ mice were immunized intranasally, mice were euthanized, and lungs harvested at day 6. (A) Representative overlay histograms show GrB expression after gating on CD4 + , CD8 + T cells, or NK cells in the lung. (B) Shown are the percentages of CD4, CD8, or NK cells expressing GrB as well as the GrB MFI of each population. (C) Representative FACS plots in the lung after ex vivo restimulation for 4-6 h with NP and M peptides. (D) Absolute number of cytokine-producing CD4 and CD8 cells were enumerated after restimulation. Single * in the CD4 quantification denotes significance over all other groups as analyzed by ANOVA. Data represent two independent experiments ( n = 4-5 mice per group) given in mean percentage of cytokine positive cells + SD * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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- Figure 3 Viral MAIT cell activation in vitro . MAIT cells from healthy individuals were analysed by flow cytometry, gated on live CD3 + CD161 ++ Valpha7.2 + cells. ( a , b ) PBMC's ( n =7) were co-cultured with autologous monocyte-derived DC's exposed to DENV (MOI=1) as described in 'Methods'. ( c - e ) CD8 + T cells isolated from PBMC's ( n =11-12) were co-cultured with IAV-exposed macrophages (MOI=1) as described in 'Methods', unless indicated otherwise. ( f ) CD8 + T cells isolated from PBMC's ( n =11-12) were co-cultured with macrophages exposed to the clinical H3N2 influenza A strain (A/England/691/2010 ( n =7)) or influenza B (B/Florida/04/2006 ( n =8)) (MOI=1) as described in 'Methods'. ( g , h ) CD8 + T cells isolated from PBMC's ( n =7-12) co-cultured with macrophages exposed to HCV (MOI=1) as described in 'Methods'. Proportion of MAIT cells producing IFN-gamma ( a , c , d , f , g ), TNF-alpha ( c , d ), CD69 ( c , d ) or Granzyme B ( b , e , h ). ( d ) Representative flow cytometry plots. All data are representative from at least two independent experiments. Bars represent means+-s.e.m. Statistical significance was determined with the Kruskal-Wallis test followed by the Dunns' test ( f ) or the Mann-Whitney test ( a , b , e , g , h ). ns>0.05, * P 0.05, *** P
