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LearnMA5-11587
antibody from Invitrogen Antibodies
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- MA5-11587 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Granzyme B Monoclonal Antibody (GZB01)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-11587 targets Granzyme B in IHC (P) applications and shows reactivity with Human samples.
- Antibody clone number
- GZB01
- Concentration
- Conc. Not Determined
Submitted references Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
Disease-specific molecular events in cortical multiple sclerosis lesions.
Invasion-associated genes identified by gene expression profiling in extranodal natural killer/T-cell lymphoma, nasal type.
Characterization of the inflammatory response to solid cancer metastases in the human brain.
Immunohistochemical expression of granzyme B and perforin in discoid lupus erythematosus.
Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type.
Tumorous proliferations of plasmacytoid dendritic cells and Langerhans cells associated with acute myeloid leukaemia.
Leukocyte composition of human breast cancer.
Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of 17 Chinese cases.
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.
Study of cellular immune response against Hepatitis E virus (HEV).
Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.
Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barré syndrome.
Golombeck KS, Bönte K, Mönig C, van Loo KM, Hartwig M, Schwindt W, Widman G, Lindenau M, Becker AJ, Glatzel M, Elger CE, Wiendl H, Meuth SG, Lohmann H, Gross CC, Melzer N
Neurology(R) neuroimmunology & neuroinflammation 2016 Jun;3(3):e232
Neurology(R) neuroimmunology & neuroinflammation 2016 Jun;3(3):e232
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
Höftberger R, Leisser M, Bauer J, Lassmann H
Acta neuropathologica communications 2015 Dec 4;3:80
Acta neuropathologica communications 2015 Dec 4;3:80
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
Yang YJ, Li YX, Liu YB, Yang M, Liu K
Oncology letters 2014 May;7(5):1419-1421
Oncology letters 2014 May;7(5):1419-1421
Disease-specific molecular events in cortical multiple sclerosis lesions.
Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H
Brain : a journal of neurology 2013 Jun;136(Pt 6):1799-815
Brain : a journal of neurology 2013 Jun;136(Pt 6):1799-815
Invasion-associated genes identified by gene expression profiling in extranodal natural killer/T-cell lymphoma, nasal type.
Yu JB, Zhang YC, Yang QP, Wang XL, Tang Y, Zhao S, Mo XM, Liu WP
Leukemia & lymphoma 2013 Jan;54(1):90-8
Leukemia & lymphoma 2013 Jan;54(1):90-8
Characterization of the inflammatory response to solid cancer metastases in the human brain.
Berghoff AS, Lassmann H, Preusser M, Höftberger R
Clinical & experimental metastasis 2013 Jan;30(1):69-81
Clinical & experimental metastasis 2013 Jan;30(1):69-81
Immunohistochemical expression of granzyme B and perforin in discoid lupus erythematosus.
Abdou AG, Shoeib M, Bakry OA, El-Bality H
Ultrastructural pathology 2013 Dec;37(6):408-16
Ultrastructural pathology 2013 Dec;37(6):408-16
Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type.
Wang TT, Xu C, Liu SL, Kan B, Ran YP, Liu WP, Li GD, Wang L
Chinese medical journal 2013 Apr;126(7):1281-7
Chinese medical journal 2013 Apr;126(7):1281-7
Tumorous proliferations of plasmacytoid dendritic cells and Langerhans cells associated with acute myeloid leukaemia.
Song HL, Huang WY, Chen YP, Chang KC
Histopathology 2012 Nov;61(5):974-83
Histopathology 2012 Nov;61(5):974-83
Leukocyte composition of human breast cancer.
Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2796-801
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2796-801
Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of 17 Chinese cases.
Lu CL, Tang Y, Yang QP, Wang M, Zhao S, Bi CF, Jiang NG, Zhang WY, Liu JP, Xu X, Liu WP
Human pathology 2011 Dec;42(12):1965-78
Human pathology 2011 Dec;42(12):1965-78
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.
Lee DW, Yang JH, Lee SM, Won CH, Chang S, Lee MW, Choi JH, Moon KC
Annals of dermatology 2011 Aug;23(3):329-37
Annals of dermatology 2011 Aug;23(3):329-37
Study of cellular immune response against Hepatitis E virus (HEV).
Prabhu SB, Gupta P, Durgapal H, Rath S, Gupta SD, Acharya SK, Panda SK
Journal of viral hepatitis 2011 Aug;18(8):587-94
Journal of viral hepatitis 2011 Aug;18(8):587-94
Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?
Pozdzik AA, Berton A, Schmeiser HH, Missoum W, Decaestecker C, Salmon IJ, Vanherweghem JL, Nortier JL
Histopathology 2010 Mar;56(4):449-63
Histopathology 2010 Mar;56(4):449-63
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Estes JD, Gordon SN, Zeng M, Chahroudi AM, Dunham RM, Staprans SI, Reilly CS, Silvestri G, Haase AT
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6798-807
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6798-807
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Estes JD, Gordon SN, Zeng M, Chahroudi AM, Dunham RM, Staprans SI, Reilly CS, Silvestri G, Haase AT
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6798-807
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6798-807
Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.
Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus HG, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D
Brain pathology (Zurich, Switzerland) 2007 Oct;17(4):389-98
Brain pathology (Zurich, Switzerland) 2007 Oct;17(4):389-98
Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barré syndrome.
Wanschitz J, Maier H, Lassmann H, Budka H, Berger T
Brain : a journal of neurology 2003 Sep;126(Pt 9):2034-42
Brain : a journal of neurology 2003 Sep;126(Pt 9):2034-42
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis was performed on whole cell extracts (30 µg lysate) of NK-92 (Lane 1) and NK-92 treated with IL-2 (100 ng/mL for 48 hours) (Lane 2). The blot was probed with Anti-Granzyme B Monoclonal Antibody (GZB01) (Product # MA5-11587, 1:500 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/mL, 1:4000 dilution). A 32 kDa band corresponding to Granzyme B was observed in the cell line tested and was enhanced upon treatment.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human lymphoma stained with Granzyme B antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
