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- References [13]
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- Immunocytochemistry [1]
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- Product number
- 24721-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MDC1 antibody
- Antibody type
- Polyclonal
- Description
- MDC1 antibody (Cat. #24721-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ononin Sensitizes Papillary Thyroid Carcinoma Cells to Cisplatin by Repressing DNA Damage Response via E2F2.
Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
Astaxanthin Prevents Glucocorticoid-Induced Femoral Head Osteonecrosis by Targeting Ferroptosis through the JAK2/STAT3 Signaling Pathway.
LARP7 is required for sex chromosome silencing during meiosis in mice.
VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair.
The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo.
Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
SFN Enhanced the Radiosensitivity of Cervical Cancer Cells via Activating LATS2 and Blocking Rad51/MDC1 Recruitment to DNA Damage Site.
Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma.
Deng X, Qian X, Cheng L, Qiao D, Zhang R, Li X
International journal of endocrinology 2026;2026:8372639
International journal of endocrinology 2026;2026:8372639
Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.
Wan H, Liu Y, Chang H, Zhang K, Li Z, Ni H, Xu J, Pan B, Zhu K, Hu J, Wang S, Yang D, Wang X, Dang Y, Zhu S
European journal of medicinal chemistry 2026 Apr 5;307:118668
European journal of medicinal chemistry 2026 Apr 5;307:118668
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.
Luo CH, Fan ZW, Yu ZQ, Liu DL, Xu HR, Zhou SM, Zhu XJ, Liu HC, Shao LF, Li ZA, Xie C, Zhan JF, Sun F
Zoological research 2025 Sep 18;46(5):1079-1092
Zoological research 2025 Sep 18;46(5):1079-1092
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
Astaxanthin Prevents Glucocorticoid-Induced Femoral Head Osteonecrosis by Targeting Ferroptosis through the JAK2/STAT3 Signaling Pathway.
Lin YZ, Chen ZH, Yang JF, Han LJ, Yu YT, Zhan JN, Tan GC, Liu LY, Xie CL, Shan P, Jin C, Liu HX
Journal of agricultural and food chemistry 2025 Feb 19;73(7):4270-4287
Journal of agricultural and food chemistry 2025 Feb 19;73(7):4270-4287
LARP7 is required for sex chromosome silencing during meiosis in mice.
Tando Y, Nonomura A, Ito-Matsuoka Y, Takehara A, Okamura D, Hayashi Y, Matsui Y
PloS one 2024;19(12):e0314329
PloS one 2024;19(12):e0314329
VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair.
Wu W, Fan Z, Fu H, Ma X, Wang D, Liu H, Zhang C, Zheng H, Yang Y, Wu H, Miao X, An R, Gong Y, Tang TS, Guo C
Science advances 2024 Oct 11;10(41):eadr2643
Science advances 2024 Oct 11;10(41):eadr2643
The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo.
Lin Z, Li D, Zheng J, Yao C, Liu D, Zhang H, Feng H, Chen C, Li P, Zhang Y, Jiang B, Hu Z, Zhao Y, Shi F, Cao D, Rodriguez-Wallberg KA, Li Z, Yeung WSB, Chow LT, Wang H, Liu K
Cell reports 2024 Jan 23;43(1):113651
Cell reports 2024 Jan 23;43(1):113651
Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
Xie R, Yan Z, Jing J, Wang Y, Zhang J, Li Y, Liu X, Yu X, Wu C
DNA repair 2022 Jun;114:103330
DNA repair 2022 Jun;114:103330
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
Zhao J, Tian S, Guo Q, Bao K, Yu G, Wang X, Shen X, Zhang J, Chen J, Yang Y, Liu L, Li X, Hao J, Yang N, Liu Z, Ai D, Yang J, Zhu Y, Yao Z, Ma S, Zhang K, Shi L
Molecular cell 2022 Jul 21;82(14):2571-2587.e9
Molecular cell 2022 Jul 21;82(14):2571-2587.e9
SFN Enhanced the Radiosensitivity of Cervical Cancer Cells via Activating LATS2 and Blocking Rad51/MDC1 Recruitment to DNA Damage Site.
Wang S, Wang Y, Liu X, Yang Y, Wu S, Liu Y
Cancers 2022 Apr 8;14(8)
Cancers 2022 Apr 8;14(8)
Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma.
Zhao Y, Yi J, Tao L, Huang G, Chu X, Song H, Chen L
Cell death & disease 2018 Apr 1;9(4):433
Cell death & disease 2018 Apr 1;9(4):433
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MDC1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MDC1. This antibody recognizes human antigen. The MDC1 antibody has been validated for the following applications: ELISA, IHC, IF analysis.
