orb1822676

antibody from Biorbyt

Targeting: SNAPC4 FLJ13451, PTFalpha, SNAP190

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

orb1822676

Provider

Biorbyt

Product name

SNAPC4 Antibody

Antibody type

Monoclonal

Description

TATA-box binding protein (TBP) interactions with TBP-associated factors (TAFs) are required for the transcription of RNA polymerases. One particular TBP-TAF complex, snRNA-activating protein complex (SNAPC), is unusual in that it regulates basal transcription of both RNA polymerase II and III by binding specifically to a non-TATA-box proximal sequence element (PSE). SNAPC consists of five subunits of varying size. SNAPC binds to Oct-1 and TBP, which are activators of snRNA and RNA polymerases, respectively. The POU domain of Oct-1 binds to SNAPC 190 and effectively recruits SNAPC to the PSE. The cooperative binding of SNAPC and Oct-1 to their respective sequence elements is mediated by a nucleosome positioned between the two sequence elements. SNAPC 19 mediates the assembly of the subunits to form a functional SNAPC transcription regulator. SNAPC 50 (also designated PTFbeta) contains two zinc finger motifs and binds to SNAPC 43 (also designated PTFGamma) but not SNAPC 45 (PTFdelta).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

PCRP-SNAPC4-3A7

Vial size

100 ug

Storage

Aliquot the SNAPC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.