RAD54L

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2008]

Description

RAD54 like

Tissue specificity

Tissue enhanced (lymphoid tissue, testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (46246461 - 46278480)

Ensembl ID

ENSG00000085999  (ver. 103.38)

Orthologs

Mouse Rad54l: ENSMUSG00000028702

UniProt

Q92698

neXtProt

NX_Q92698

Human splice variants
Mouse splice variants

Protein structure