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- Antibody Data
- Antigen structure
- References [19]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 23333-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#23333-1-AP, RRID:AB_2716831
- Product name
- Eg5 antibody
- Antibody type
- Polyclonal
- Description
- Eg5 antibody (Cat. #23333-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.
Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.
Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma.
Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions.
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20.
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
Cyclovirobuxine D inhibits growth and progression of non‑small cell lung cancer cells by suppressing the KIF11‑CDC25C‑CDK1‑CyclinB1 G(2)/M phase transition regulatory network and the NFκB/JNK signaling pathway.
The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.
KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma.
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.
Pashley SL, Papageorgiou S, O'Regan L, Barone G, Robinson SW, Lucken K, Straatman KR, Roig J, Fry AM
The Journal of biological chemistry 2024 May;300(5):107144
The Journal of biological chemistry 2024 May;300(5):107144
Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.
Salazar BM, Ohi R
Molecular biology of the cell 2024 Jun 1;35(6):ar84
Molecular biology of the cell 2024 Jun 1;35(6):ar84
Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma.
Miao Y, Shen C, Zhang X, Li QQ, Pang AY, Zhao WM, Wu XY, Qian HY, Chen XD
Frontiers in bioscience (Landmark edition) 2024 Jan 17;29(1):19
Frontiers in bioscience (Landmark edition) 2024 Jan 17;29(1):19
Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions.
Kwon W, Choi DJ, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen B
International journal of molecular sciences 2024 Jan 13;25(2)
International journal of molecular sciences 2024 Jan 13;25(2)
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20.
Fatima I, Ahmad R, Barman S, Gowrikumar S, Pravoverov K, Primeaux M, Fisher KW, Singh AB, Dhawan P
British journal of cancer 2024 Apr;130(6):1046-1058
British journal of cancer 2024 Apr;130(6):1046-1058
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L
Clinical and translational medicine 2023 Sep;13(9):e1418
Clinical and translational medicine 2023 Sep;13(9):e1418
KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
Zhu L, Chen C, Kang M, Ma X, Sun X, Xue Y, Fang Y
Journal of cancer research and clinical oncology 2023 Nov;149(17):15609-15622
Journal of cancer research and clinical oncology 2023 Nov;149(17):15609-15622
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
Shi S, Guo D, Ye L, Li T, Fei Q, Lin M, Yu X, Jin K, Wu W
Cell death & disease 2023 Nov 27;14(11):778
Cell death & disease 2023 Nov 27;14(11):778
Cyclovirobuxine D inhibits growth and progression of non‑small cell lung cancer cells by suppressing the KIF11‑CDC25C‑CDK1‑CyclinB1 G(2)/M phase transition regulatory network and the NFκB/JNK signaling pathway.
Xue T, Chen Y, Xu J, Du W, Kong P, Zhang X
International journal of oncology 2023 May;62(5)
International journal of oncology 2023 May;62(5)
The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.
Kaprio H, Siddiqui A, Saustila L, Heuser VD, Gardberg M
Scientific reports 2023 Mar 25;13(1):4884
Scientific reports 2023 Mar 25;13(1):4884
KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma.
Zhou Y, Chen X, Li B, Li Y, Zhang B
Translational andrology and urology 2023 Apr 28;12(4):594-611
Translational andrology and urology 2023 Apr 28;12(4):594-611
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842
Frontiers in pharmacology 2022;13:997842
The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.
Shi Y, Cui X, Jiang T, Pan Y, Lin Y, Feng X, Ding Z, Yang C, Tan Y, Wang H, Dong L
Cell death & disease 2022 Sep 19;13(9):799
Cell death & disease 2022 Sep 19;13(9):799
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Wei D, Rui B, Qingquan F, Chen C, Ping HY, Xiaoling S, Hao W, Jun G
International journal of biological sciences 2021;17(2):514-526
International journal of biological sciences 2021;17(2):514-526
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
Li X, Huang W, Huang W, Wei T, Zhu W, Chen G, Zhang J
American journal of translational research 2020;12(5):1614-1639
American journal of translational research 2020;12(5):1614-1639
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Terribas E, Fernández M, Mazuelas H, Fernández-Rodríguez J, Biayna J, Blanco I, Bernal G, Ramos-Oliver I, Thomas C, Guha R, Zhang X, Gel B, Romagosa C, Ferrer M, Lázaro C, Serra E
Neuro-oncology advances 2020 Jul;2(Suppl 1):i62-i74
Neuro-oncology advances 2020 Jul;2(Suppl 1):i62-i74
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, Li Y, Chen H
International journal of cancer 2020 Jul 15;147(2):584-592
International journal of cancer 2020 Jul 15;147(2):584-592
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Wang B, Yu J, Sun Z, Luh F, Lin D, Shen Y, Wang T, Zhang Q, Liu X
Molecular carcinogenesis 2020 Aug;59(8):908-922
Molecular carcinogenesis 2020 Aug;59(8):908-922
Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.
Saeki E, Yasuhira S, Shibazaki M, Tada H, Doita M, Masuda T, Maesawa C
PloS one 2018;13(12):e0209296
PloS one 2018;13(12):e0209296
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-13 cells were subjected to SDS PAGE followed by western blot with 23333-1-AP( KIF11 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KIF11 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human KIF11. This antibody recognizes human antigen. The KIF11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
