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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Product number
- 620501 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#620501, RRID:AB_315921
- Product name
- Purified anti-Eg5 Phospho (Thr927)
- Antibody type
- Polyclonal
- Antigen
- Modified peptide
- Description
- hEg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. This protein is a catalytic kinesin motor with coiled-coil and Smc domains. hEg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. This motor protein is required for establishing the bipolar spindle. hEg5 is modified by phosphorylation on Thr927 by Cdc2 to allow association with the spindle apparatus. hEg5 has been shown to interact with the thyroid hormone receptor in presence of thyroid hormone and Cdc2. The Poly6205 antibody has been shown to react with phosphorylated human Eg5 (Thr927) by Western blot.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 50 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references A role for IkappaB kinase 2 in bipolar spindle assembly.
Irelan JT, Murphy TJ, DeJesus PD, Teo H, Xu D, Gomez-Ferreria MA, Zhou Y, Miraglia LJ, Rines DR, Verma IM, Sharp DJ, Tergaonkar V, Chanda SK
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16940-5
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16940-5
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