Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 627802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#627802, RRID:AB_2130963
- Product name
- Purified anti-Eg5
- Antibody type
- Monoclonal
- Antigen
- Amino Acid: 200-500 of human Eg5
- Description
- Eg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. This protein is a catalytic kinesin motor with coiled-coil and Smc domains. Eg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. This motor protein is required for establishing the bipolar spindle. hEg5 is modified by phosphorylation on Thr927 by Cdc2 to allow association with the spindle apparatus. Eg5 has been shown to interact with the thyroid hormone receptor in presence of thyroid hormone and Cdc2. The 10C7/Eg5 monoclonal antibody has been shown to react with human and mouse Eg5 by Western blot.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.
Submitted references Kinesin molecular motor Eg5 functions during polypeptide synthesis.
Bartoli KM, Jakovljevic J, Woolford JL Jr, Saunders WS
Molecular biology of the cell 2011 Sep;22(18):3420-30
Molecular biology of the cell 2011 Sep;22(18):3420-30
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