BS7924

antibody from Bioworld Technology, Inc
Targeting: GSTZ1 GSTZ1-1, MAAI, MAI
Provider product page for BS7924
Western blot
Immunohistochemistry

Antibody data

Product number
BS7924 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GSTZ1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GSTZ1.
Description
In humans, maleylacetoacetate isomerase (MAAI, also known as GSTZ1-1) catalyzes the conversion of maleylacetoacetate to fumarylacetoacetate, the fifth step in the phenylalanine/phenylacetate degradation pathway. Deficiencies in other steps of this pathway cause metabolic diseases, including type I tyrosinemia and phenylketonuria. The glutathione S-transferases (GSTs) are found in all aerobic organisms and catalyze the conjugation of glutathione to a wide variety of electrophilic substrates. By sequence alignment and phylogenetic analysis, a new subgroup of GST-like proteins from human, C. elegans, and carnation were identified. Human MAAI is 38% and 49% identical to the carnation and C. elegans proteins, respectively. Recombinant human MAAI is a dimer. The enzyme exhibits limited activity with known GST substrates. Western blot analysis indicates that MAAI is most abundant in liver, with lower levels detected in skeletal muscle and brain.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GSTZ1 protein structure - BS7924 shown in red.