Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7924 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GSTZ1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human GSTZ1.
- Description
- In humans, maleylacetoacetate isomerase (MAAI, also known as GSTZ1-1) catalyzes the conversion of maleylacetoacetate to fumarylacetoacetate, the fifth step in the phenylalanine/phenylacetate degradation pathway. Deficiencies in other steps of this pathway cause metabolic diseases, including type I tyrosinemia and phenylketonuria. The glutathione S-transferases (GSTs) are found in all aerobic organisms and catalyze the conjugation of glutathione to a wide variety of electrophilic substrates. By sequence alignment and phylogenetic analysis, a new subgroup of GST-like proteins from human, C. elegans, and carnation were identified. Human MAAI is 38% and 49% identical to the carnation and C. elegans proteins, respectively. Recombinant human MAAI is a dimer. The enzyme exhibits limited activity with known GST substrates. Western blot analysis indicates that MAAI is most abundant in liver, with lower levels detected in skeletal muscle and brain.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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