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- Antibody Data
- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [4]
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- Product number
- NBP1-82991 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-82991, RRID:AB_11034164
- Product name
- Rabbit Polyclonal ZEB2 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human ZEB2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references USP18 deubiquitinates and stabilizes Twist1 to promote epithelial-mesenchymal transition in glioblastoma cells.
MicroRNA-940 inhibits epithelial-mesenchymal transition of glioma cells via targeting ZEB2.
Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression.
Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration.
GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity.
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.
Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.
Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival.
Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma.
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.
Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas.
Cai X, Feng S, Zhang J, Qiu W, Qian M, Wang Y
American journal of cancer research 2020;10(4):1156-1169
American journal of cancer research 2020;10(4):1156-1169
MicroRNA-940 inhibits epithelial-mesenchymal transition of glioma cells via targeting ZEB2.
Xu R, Zhou F, Yu T, Xu G, Zhang J, Wang Y, Zhao L, Liu N
American journal of translational research 2019;11(12):7351-7363
American journal of translational research 2019;11(12):7351-7363
Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression.
Wang P, Liu X, Han G, Dai S, Ni Q, Xiao S, Huang J
Cell cycle (Georgetown, Tex.) 2019 Sep;18(18):2359-2376
Cell cycle (Georgetown, Tex.) 2019 Sep;18(18):2359-2376
Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.
Feng S, Cai X, Li Y, Jian X, Zhang L, Li B
Journal of experimental & clinical cancer research : CR 2019 Feb 6;38(1):57
Journal of experimental & clinical cancer research : CR 2019 Feb 6;38(1):57
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ
Oncotarget 2019 Apr 5;10(27):2586-2606
Oncotarget 2019 Apr 5;10(27):2586-2606
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration.
Yang S, Toledo EM, Rosmaninho P, Peng C, Uhlén P, Castro DS, Arenas E
Communications biology 2018;1:75
Communications biology 2018;1:75
GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity.
Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, Gaidarova S, Moreno S, Tuininga K, Dougherty P, McCullar V, Howard P, Sarhan D, Taras E, Schlums H, Abbot S, Shoemaker D, Bryceson YT, Blazar BR, Wolchko S, Cooley S, Miller JS
Cancer research 2017 Oct 15;77(20):5664-5675
Cancer research 2017 Oct 15;77(20):5664-5675
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
Lee E, Wang J, Yumoto K, Jung Y, Cackowski FC, Decker AM, Li Y, Franceschi RT, Pienta KJ, Taichman RS
Neoplasia (New York, N.Y.) 2016 Sep;18(9):553-66
Neoplasia (New York, N.Y.) 2016 Sep;18(9):553-66
The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M
FEBS letters 2016 Jan;590(2):270-8
FEBS letters 2016 Jan;590(2):270-8
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.
Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R
Nature 2015 Nov 26;527(7579):525-530
Nature 2015 Nov 26;527(7579):525-530
Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.
Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, Gheldof A, De Craene B, Van Gele M, Brochez L, Udupi GM, Rafferty M, Balint B, Gallagher WM, Ghanem G, Huylebroeck D, Haigh J, van den Oord J, Larue L, Davidson I, Marine JC, Berx G
Cell death and differentiation 2014 Aug;21(8):1250-61
Cell death and differentiation 2014 Aug;21(8):1250-61
Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival.
Fang Y, Wei J, Cao J, Zhao H, Liao B, Qiu S, Wang D, Luo J, Chen W
PloS one 2013;8(5):e62558
PloS one 2013;8(5):e62558
Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma.
Cai MY, Luo RZ, Chen JW, Pei XQ, Lu JB, Hou JH, Yun JP
PloS one 2012;7(2):e32838
PloS one 2012;7(2):e32838
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.
Piao Y, Liang J, Holmes L, Zurita AJ, Henry V, Heymach JV, de Groot JF
Neuro-oncology 2012 Nov;14(11):1379-92
Neuro-oncology 2012 Nov;14(11):1379-92
Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas.
Wensman H, Göransson H, Leuchowius KJ, Strömberg S, Pontén F, Isaksson A, Rutteman GR, Heldin NE, Pejler G, Hellmén E
Breast cancer research and treatment 2009 Nov;118(2):333-43
Breast cancer research and treatment 2009 Nov;118(2):333-43
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ZEB2 Antibody [NBP1-82991] - Analysis in human cell lines SK-MEL-30 and Caco-2 using Anti-ZEB2 antibody. Corresponding ZEB2 RNA-seq data are presented for the same cell lines. Loading control: Anti-HDAC1.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Staining of human colon shows moderate nuclear positivity in a subset of lymphoid cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Staining of human cerebral cortex shows moderate nuclear positivity in glial cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Staining of human glioma shows moderate nuclear positivity in tumor cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Staining of human pancreas shows no positivity as expected.
