Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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Validation data
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- Product number
- PAB2643 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB2643, RRID:AB_1570898
- Product name
- ACVR2A polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of ACVR2A.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.
Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.
Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors.
Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y
The Journal of clinical investigation 2012 Mar;122(3):873-85
The Journal of clinical investigation 2012 Mar;122(3):873-85
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.
Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM
Gastroenterology 2004 Mar;126(3):654-9
Gastroenterology 2004 Mar;126(3):654-9
Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.
Martins da Silva SJ, Bayne RA, Cambray N, Hartley PS, McNeilly AS, Anderson RA
Developmental biology 2004 Feb 15;266(2):334-45
Developmental biology 2004 Feb 15;266(2):334-45
Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors.
Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F, Selaru FM, Deacu E, Sterian A, Shibata D, Abraham JM, Meltzer SJ
Laboratory investigation; a journal of technical methods and pathology 2003 Dec;83(12):1867-71
Laboratory investigation; a journal of technical methods and pathology 2003 Dec;83(12):1867-71
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of ACVR2A (arrow) using ACVR2A polyclonal antibody (Cat # PAB2643). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of ACVR2A polyclonal antibody (Cat # PAB2643) in mouse liver, brain and kidney tissue lysates (35 ug/lane). ACVR2A (arrow) was detected using the purified polyclonal antibody.
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVR2A polyclonal antibody (Cat # PAB2643) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)