C8G

The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

Description

Complement C8 gamma chain

Tissue specificity

Tissue enriched (liver)

Predicted location

Secreted to blood

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (136945185 - 136946975)

Ensembl ID

ENSG00000176919  (ver. 103.38)

Orthologs

Mouse C8g: ENSMUSG00000015083

UniProt

P07360

neXtProt

NX_P07360

Human splice variants
Mouse splice variants

Protein structure