13194-1-AP

antibody from Proteintech Group

Targeting: FXR1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

13194-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13194-1-AP, RRID:AB_2110702

Product name

FXR1 antibody

Antibody type

Polyclonal

Description

KD/KO validated FXR1 antibody (Cat. #13194-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis.

Li Y, Mao L, Liang B, Xie L, Xiang W, Kee K
Cell proliferation 2026 Apr;59(4):e70181

---

Long noncoding RNA AC007637.1 inhibits tumorigenesis by regulating the Trim25/PCNA axis in colorectal cancer.

Wang X, Li J, Hao C, Cui K, Tian L, Zhao J, Li C, Feng Y, Yao S, Fei B, Mao X, Huang Z
Journal of advanced research 2026 Apr 6;

---

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.

Sun Y, Qu Y, Yang Z, Lv B, Wang G, Fan K, Wang Y, Pan J, Du Z, Yu Y
Frontiers in pharmacology 2025;16:1569856

---

Isoform usage as a distinct regulatory layer driving nutrient-responsive metabolic adaptation.

Li J, Cai C, Teo WW, Chin KS, Naing YT, Song S, Nelson F, Qiang L, Xu D, Sun L
Cell metabolism 2025 Mar 4;37(3):772-787.e6

---

Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.

Tang CT, Wu Y, Tao Q, Zeng CY, Chen YX
Journal of pharmaceutical analysis 2025 Apr;15(4):101121

---

Multiplexed Immunofluorescence and Single-Molecule RNA Fluorescence In Situ Hybridization in Mouse Skeletal Myofibers.

Denes LT, Kelley CP, Wang ET
Methods in molecular biology (Clifton, N.J.) 2024;2784:163-176

---

Obeticholic acid protects against lithocholic acid-induced exogenous cell apoptosis during cholestatic liver injury.

Lu Q, Zhu Y, Wang C, Zhang R, Miao Y, Chai Y, Jiang Z, Yu Q
Life sciences 2024 Jan 15;337:122355

---

hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.

Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769

---

Mulberry leaf polysaccharides ameliorate glucose and lipid metabolism disorders via the gut microbiota-bile acids metabolic pathway.

Dai H, Shan Z, Shi L, Duan Y, An Y, He C, Lyu Y, Zhao Y, Wang M, Du Y, Xie J, Yang Y, Zhao B
International journal of biological macromolecules 2024 Dec;282(Pt 2):136876

---

The Spatial-Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis.

Wang W, Fan X, Liu W, Huang Y, Zhao S, Yang Y, Tang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2405157

---

Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.

Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692

---

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers.

Sun Y, Zhang X, Hang D, Lau HC, Du J, Liu C, Xie M, Pan Y, Wang L, Liang C, Zhou X, Chen D, Rong J, Zhao Z, Cheung AH, Wu Y, Gou H, Wong CC, Du L, Deng J, Hu Z, Shen H, Miao Y, Yu J
Cancer cell 2024 Aug 12;42(8):1386-1400.e8

---

FXR1 stabilizes SNORD63 to regulate blood-tumor barrier permeability through SNORD63 mediated 2'-O-methylation of POU6F1.

Liang C, Zhai B, Wei D, Niu B, Ma J, Yao Y, Lin Y, Liu Y, Liu X, Wang P
International journal of biological macromolecules 2024 Apr;265(Pt 1):130642

---

Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.

Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974

---

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701

---

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344

---

FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.

Shimizu H, Hohjoh H
Scientific reports 2023 Feb 2;13(1):1956

---

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.

He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274

---

Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.

Datta C, Truesdell SS, Wu KQ, Bukhari SIA, Ngue H, Buchanan B, Le Tonqueze O, Lee S, Kollu S, Granovetter MA, Boukhali M, Kreuzer J, Batool MS, Balaj L, Haas W, Vasudevan S
Science advances 2022 Oct 28;8(43):eabo1304

---

Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.

Hou Z, Ding Q, Li Y, Zhao Z, Yan F, Li Y, Wang X, Xu J, Chen W, Wu G, Ruan X, Zhao L
EBioMedicine 2022 Aug;82:104181

---

Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.

Denes LT, Kelley CP, Wang ET
Nature communications 2021 Oct 27;12(1):6079

---

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.

George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P
Cell reports 2021 Nov 2;37(5):109934

---

Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.

Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885

---

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132

---

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.

Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP
Cell 2020 Apr 16;181(2):306-324.e28

---

The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.

Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA, Whitehouse A
eLife 2019 Oct 24;8

---

FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.

Cao S, Zheng J, Liu X, Liu Y, Ruan X, Ma J, Liu L, Wang D, Yang C, Cai H, Li Z, Feng Z, Xue Y
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):37

---

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Estañ MC, Fernández-Núñez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bönnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL
Nature communications 2019 Feb 15;10(1):797

---

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.

Wang GX, Smith SJ, Mourrain P
eLife 2016 Oct 22;5

---

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.

Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7521-37

---

Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

Wang GX, Smith SJ, Mourrain P
Neuron 2014 Dec 17;84(6):1273-86

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse testis tissue were subjected to SDS PAGE followed by western blot with 13194-1-AP(FXR1 antibody) at dilution of 1:300

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The FXR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FXR1. This antibody recognizes human,mouse,rat antigen. The FXR1 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.

Appendix

13194-1-AP.pdf

Show more

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-FXR1 (IP:13194-1-AP, 3ug; Detection:13194-1-AP 1:800) with mouse skeletal muscle tissue lysate 8000ug.

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 13194-1-AP(FXR1 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue