55469-1-AP

antibody from Proteintech Group

Targeting: RAB7A CMT2B, RAB7

Provider product page for 55469-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [50]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 55469-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55469-1-AP, RRID:AB_11182831
Product name: RAB7A antibody
Antibody type: Polyclonal
Description: KD/KO validated RAB7A antibody (Cat. #55469-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RAB7A protein structure - 55469-1-AP shown in red.

Submitted references Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7.

Li C, Fu J, Shao S, Luo ZQ
PLoS pathogens 2024 May;20(5):e1011783

ALIX and TSG101 are essential for cellular entry and replication of two porcine alphacoronaviruses.

Chen X, Liang Y, Weng Z, Hu C, Peng Y, Sun Y, Gao Q, Huang Z, Tang S, Gong L, Zhang G
PLoS pathogens 2024 Mar;20(3):e1012103

Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network.

Li J, Wang H, Chen H, Li X, Liu Y, Hou H, Hu Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114431

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.

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bioRxiv : the preprint server for biology 2024 Mar 15;

Loss of SARM1 ameliorates secondary thalamic neurodegeneration after cerebral infarction.

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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Feb;44(2):224-238

Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP.

Mulligan RJ, Magaj MM, Digilio L, Redemann S, Yap CC, Winckler B
bioRxiv : the preprint server for biology 2024 Feb 17;

Subcellular localization of viral proteins after porcine epidemic diarrhea virus infection and their roles in the viral life cycle.

Chen XN, Cai ST, Liang YF, Weng ZJ, Song TQ, Li X, Sun YS, Peng YZ, Huang Z, Gao Q, Tang SQ, Zhang GH, Gong L
International journal of biological macromolecules 2024 Aug;274(Pt 2):133401

The Prognostic Biomarker RAB7A Promotes Growth and Metastasis of Liver Cancer Cells by Regulating Glycolysis and YAP1 Activation.

Zhang JY, Zhu X, Liu Y, Wu X
Journal of cellular biochemistry 2024 Aug;125(8):e30621

Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.

Arab M, Nayak SC, Vitali T, Lowe M
Methods in molecular biology (Clifton, N.J.) 2023;2557:101-111

Emodin and rhapontigenin inhibit the replication of African swine fever virus by interfering with virus entry.

Guo Y, Chen Y, Wang Q, Wang Z, Gong L, Sun Y, Song Z, Chang H, Zhang G, Wang H
Veterinary microbiology 2023 Sep;284:109794

EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer.

Wu PS, Lin MH, Hsiao JC, Lin PY, Pan SH, Chen YJ
Molecular & cellular proteomics : MCP 2023 Sep;22(9):100624

Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.

Sun Y, Zheng H, Qian L, Liu Y, Zhu D, Xu Z, Chang W, Xu J, Wang L, Sun B, Gu L, Yuan H, Lou H
JACS Au 2023 Oct 23;3(10):2749-2762

C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.

Zhang S, Tong M, Zheng D, Huang H, Li L, Ungermann C, Pan Y, Luo H, Lei M, Tang Z, Fu W, Chen S, Liu X, Zhong Q
Nature communications 2023 Oct 11;14(1):6360

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.

Biswas S, Mandal G, Anadon CM, Chaurio RA, Lopez-Bailon LU, Nagy MZ, Mine JA, Hänggi K, Sprenger KB, Innamarato P, Harro CM, Powers JJ, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez BA, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR
Immunity 2023 Nov 14;56(11):2570-2583.e6

25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.

Zhang L, Yi Y, Wang T, Song M, Guo K, Zhang Y
Veterinary microbiology 2023 Mar;278:109668

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857

The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.

Niu J, Yan T, Guo W, Wang W, Ren T, Huang Y, Zhao Z, Yu Y, Chen C, Huang Q, Lou J, Guo L
Autophagy 2023 Jun;19(6):1693-1710

Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism.

Chen K, Tang F, Du B, Yue ZZ, Jiao LL, Ding XL, Tuo QZ, Meng J, He SY, Dai L, Lei P, Wei XW
MedComm 2023 Dec;4(6):e429

Porcine Enteric Alphacoronavirus Entry through Multiple Pathways (Caveolae, Clathrin, and Macropinocytosis) Requires Rab GTPases for Endosomal Transport.

Chen XN, Liang YF, Weng ZJ, Quan WP, Hu C, Peng YZ, Sun YS, Gao Q, Huang Z, Zhang GH, Gong L
Journal of virology 2023 Apr 27;97(4):e0021023

Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.

Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675

Liu Q, Bai Y, Shi X, Guo D, Wang Y, Wang Y, Guo WZ, Zhang S
Scientific reports 2022 Oct 19;12(1):17492

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA
Cell reports 2022 May 3;39(5):110776

Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids.

Yang QY, Yang YL, Tang YX, Qin P, Wang G, Xie JY, Chen SX, Ding C, Huang YW, Zhu SJ
PLoS pathogens 2022 Jun;18(6):e1010620

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2022 Jul;18(7):1599-1612

SorCS3 promotes the internalization of p75(NTR) to inhibit GBM progression.

Zhang Y, Li Y, Fan Y, Zhang X, Tang Z, Qi J, Zhao B, Li F, Chen X, Liang H, Xu H, Li D
Cell death & disease 2022 Apr 7;13(4):313

The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction.

Wen C, Zhou Y, Xu Y, Tan H, Pang C, Liu H, Liu K, Wei L, Luo H, Qin T, He C, Liu C, Zhou C
Frontiers in cell and developmental biology 2021;9:706768

Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions.

Yu W, Ke X, Li M, Ye P, Peng J, Li H
Open medicine (Warsaw, Poland) 2021;16(1):1428-1437

Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion.

Shi R, Hou L, Wei L, Quan R, Zhou B, Jiang H, Wang J, Zhu S, Song J, Wang D, Liu J
Frontiers in microbiology 2021;12:636307

Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.

Yang Y, Wang J, Zhang Y, Hu X, Li L, Chen P
Aging 2021 Oct 25;13(20):23769-23779

Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.

Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)

Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.

Wu K, Chen GH, Hogstrand C, Ling SC, Wu LX, Luo Z
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 May;65:126732

Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer's disease.

Lim JY, In Park S, Park SA, Jeon JH, Jung HY, Yon JM, Jeun SS, Lim HK, Kim SW
Stem cell research & therapy 2021 Jul 13;12(1):402

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.

Hu P, Wang J, Qing Y, Li H, Sun W, Yu X, Hui H, Guo Q, Xu J
Cell death & disease 2021 Jan 13;12(1):80

RAB31 marks and controls an ESCRT-independent exosome pathway.

Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177

Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.

Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21

Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.

Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D, Fu M, Ma L, Song Y, Zhang W, Zhan Q
Signal transduction and targeted therapy 2021 Apr 16;6(1):152

TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.

Hu J, Ding X, Tian S, Chu Y, Liu Z, Li Y, Li X, Wang G, Wang L, Wang Z
Cell death & disease 2021 Apr 12;12(4):391

Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.

Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385

Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.

Tang D, Liu X, Chen K, Li Z, Dai Y, Xu J, Zhang HT, Gao X, Liu L
Aging 2020 Jun 27;12(13):13297-13317

Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.

Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks MM, Parker R, Goodfellow IG, Ruggieri A, Locker N
PLoS pathogens 2020 Jan;16(1):e1008250

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.

Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L
Nature communications 2020 Jan 24;11(1):479

The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.

Bai B, Wang XF, Zhang M, Na L, Zhang X, Zhang H, Yang Z, Wang X
Viruses 2020 Feb 16;12(2)

CHML promotes liver cancer metastasis by facilitating Rab14 recycle.

Chen TW, Yin FF, Yuan YM, Guan DX, Zhang E, Zhang FK, Jiang H, Ma N, Wang JJ, Ni QZ, Qiu L, Feng J, Zhang XL, Bao Y, Wang K, Cheng SQ, Wang XF, Wang X, Li JJ, Xie D
Nature communications 2019 Jun 7;10(1):2510

Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants.

Li W, Zhang J, Zou L, Cui J, Su F, Jin J, Xiao F, Liu M, Zhao G
Oncology reports 2019 Dec;42(6):2788-2796

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation.

Chang M, Song X, Geng X, Wang X, Wang W, Chen TC, Xie L, Song X
Journal of experimental & clinical cancer research : CR 2018 Oct 16;37(1):250

Reduced graphene oxide triggered epithelial-mesenchymal transition in A549 cells.

Liao Y, Wang W, Huang X, Sun Y, Tian S, Cai P
Scientific reports 2018 Oct 12;8(1):15188

Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.

Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J, Yuan Z
Journal of virology 2018 Dec 15;92(24)

Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

Chen R, Zhao X, Wang Y, Xie Y, Liu J
Scientific reports 2017 Jan 18;7:40783

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway.

Song P, Trajkovic K, Tsunemi T, Krainc D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Feb 24;36(8):2425-37

Synergism between upregulation of Rab7 and inhibition of autophagic degradation caused by mycoplasma facilitates intracellular mycoplasma infection.

Hu X, Yu J, Zhou X, Li Z, Xia Y, Luo Z, Wu Y
Molecular medicine reports 2014 Mar;9(3):793-800

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 55469-1-AP(RAB7A antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RAB7A antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human RAB7A. This antibody recognizes human,mouse,rat antigen. The RAB7A antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 55469-1-AP.pdf

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