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- Antibody Data
- Antigen structure
- References [141]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 10599-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10599-1-AP, RRID:AB_2062602
- Product name
- BAG3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BAG3 antibody (Cat. #10599-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Rosmarinic acid alleviates ischemic stroke by targeting BAG3 to modulate autophagy via the P62-Keap1-Nrf2 pathway.
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
Depletion of BIS in astrocytes aggravates reactive gliosis following photothrombotic brain injury.
C-terminal extension of HSPB6 in a family with myopathy and cataract.
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.
Altered BAG3-insulin colocalization is associated with impaired first phase insulin secretion in humans.
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease.
METTL3-mediated m(6)A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis.
DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus.
METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3.
A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy.
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
Autophagic signatures in peripheral blood mononuclear cells from Parkinson's disease patients.
Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy-Associated Cardiomyopathy.
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts.
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic.
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction.
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy.
BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
Combined Treatment with Bojungikgi-tang (Buzhong Yiqi Decoction) and Riluzole Attenuates Cell Death in TDP-43-Expressing Cells.
AZD7762 induces CRBN dependent BAG3 degradation through ubiquitin-proteasome pathway.
Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying BAG3 V468M mutation in its BAG domain.
Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6.
BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates.
2'-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1.
BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.
BAG3 regulates bone marrow mesenchymal stem cell proliferation by targeting INTS7.
Proteotoxic stress-induced autophagy is regulated by the NRF2 pathway via extracellular vesicles.
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart.
Functional analysis of a common BAG3 allele associated with protection from heart failure.
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes.
BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta.
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies.
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours.
Myofibrillar myopathy hallmarks associated with ZAK deficiency.
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.
Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis.
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration.
An Important Role for RPRD1B in the Heat Shock Response.
BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson's disease.
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles.
Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module.
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.
Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation.
Triangulating variation in the population to define mechanisms for precision management of genetic disease.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Locus specific epigenetic modalities of random allelic expression imbalance.
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
Hsp22 Deficiency Induces Age-Dependent Cardiac Dilation and Dysfunction by Impairing Autophagy, Metabolism, and Oxidative Response.
Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ.
Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H(2)O(2): implications for HIV-associated neurological disorders.
Overexpression of human BAG3(P209L) in mice causes restrictive cardiomyopathy.
BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
TRIM28 functions as a negative regulator of aggresome formation.
The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap.
Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions.
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction.
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
Induction of BIS Protein During Astroglial and Fibrotic Scar Formation After Mitochondrial Toxin-Mediated Neuronal Injury in Rats.
Sprint and Strength Training Modulates Autophagy and Proteostasis in Aging Sprinters.
Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein.
BAG3 Proteomic Signature under Proteostasis Stress.
BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.
Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
An integrative correlation of myopathology, phenotype and genotype in late onset Pompe disease.
Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.
Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-Terminal (181)L-(185)L and Plays a Negative Regulation Role during Viral Lytic Infection.
The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.
Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes.
Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes.
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells.
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Imbalances in protein homeostasis caused by mutant desmin.
Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection.
Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3.
Transcriptional upregulation of Bag3, a chaperone-assisted selective autophagy factor, in animal models of KY-deficient hereditary myopathy.
Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice.
Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy.
HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.
Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex.
A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.
Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.
A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.
Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.
Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury.
BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy.
Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing.
Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D.
Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction.
Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.
The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity.
Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
BAG3 facilitates the clearance of endogenous tau in primary neurons.
Myofibrillar instability exacerbated by acute exercise in filaminopathy.
Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.
Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins.
WW domain of BAG3 is required for the induction of autophagy in glioma cells.
Analysis of HDAC6 and BAG3-aggresome pathways in African swine fever viral factory formation.
Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy.
Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics.
14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag.
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner.
The Hsc/Hsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells.
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Autoregulation of co-chaperone BAG3 gene transcription.
Liu C, Liu D, Gao P, Zhang Y, He Y, Wang C, Zhang J, Ma A, Zhao H, Tang H, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:157904
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:157904
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
Rodwell-Bullock J, Blau E, Ganguly A, Deaton C, Johnson GVW
American journal of physiology. Cell physiology 2026 May 1;330(5):C1286-C1295
American journal of physiology. Cell physiology 2026 May 1;330(5):C1286-C1295
Depletion of BIS in astrocytes aggravates reactive gliosis following photothrombotic brain injury.
Jung SY, Hwang JW, Yun HH, Yoo K, Kim HL, Oh Y, Jung SW, Kim JY, Hwang SN, Kim SY, Jung SH, Lee MY, Lee JH, Riew TR
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 May 1;30(3):251-264
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 May 1;30(3):251-264
C-terminal extension of HSPB6 in a family with myopathy and cataract.
Sarparanta J, Jonson PH, Vihola A, Luque H, Villar-Quiles RN, Stojkovic T, Sian V, Walder C, Suominen T, Hackman P, Romero NB, Eymard B, Udd B
Human molecular genetics 2026 Feb 8;35(1)
Human molecular genetics 2026 Feb 8;35(1)
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.
Filippi K, Graf-Riesen K, Kuppusamy M, Unger A, Kimura K, Matijass M, Baeta H, Podlacha M, Haertter D, Kudin AP, Wiemann M, Węgrzyn G, Kornblum C, Reimann J, Linke WA, Huesgen PF, Kunz WS, Fleischmann BK, Hesse M
Nature communications 2026 Apr 11;17(1)
Nature communications 2026 Apr 11;17(1)
Altered BAG3-insulin colocalization is associated with impaired first phase insulin secretion in humans.
Damiani V, Di Giuseppe G, Gliozzo G, Ciccarelli G, Pizzinato E, Del Pizzo F, Fruci D, Brunetti M, Soldovieri L, Quero G, Mari A, Alfieri S, Pontecorvi A, Giaccari A, De Laurenzi V, Mezza T
Diabetes research and clinical practice 2025 Nov;229:112232
Diabetes research and clinical practice 2025 Nov;229:112232
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease.
Xia L, Li J, Pang Y, Dai C, Xu M, Du Y, Tian Q, Yi L, Wu B, Chen M, Qiu Y, Cheng C, Wang YT, Song W, Dong Z
Science advances 2025 May 23;11(21):eadt7981
Science advances 2025 May 23;11(21):eadt7981
METTL3-mediated m(6)A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis.
Wang L, Wang H, Liu T, Zhou X, Kuai S, Ji Z, Shen H
International immunopharmacology 2025 Jun 26;159:114905
International immunopharmacology 2025 Jun 26;159:114905
DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus.
Ji X, Zhi M, Gu X, Han Y, Lan X, Song L, Sun P, Li J, Qi X, Feng Q
Microbiome 2025 Jul 14;13(1):164
Microbiome 2025 Jul 14;13(1):164
METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3.
Zhan P, Cheng Y, Wu Y, Lu J, Wen J, Chi X, Luo C, Peng Y, Chen X, Wang F, Yin Z, Xie C
NPJ precision oncology 2025 Jul 10;9(1):234
NPJ precision oncology 2025 Jul 10;9(1):234
A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy.
Morsink MAJ, Wang BZ, Watkins JM, Zhuang RZ, Zhang X, Chesnais F, Chen C, Lock RI, Fine BM, Vunjak-Novakovic G
Journal of tissue engineering 2025 Jan-Dec;16:20417314251371296
Journal of tissue engineering 2025 Jan-Dec;16:20417314251371296
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
Wang BZ, Morsink MA, Kim SW, Luo LJ, Zhang X, Soni RK, Lock RI, Rao J, Kim Y, Zhang A, Neyazi M, Gorham JM, Kim Y, Brown K, DeLaughter DM, Zhang Q, McDonough B, Watkins JM, Cunningham KM, Oudit GY, Fine BM, Seidman CE, Seidman JG, Vunjak-Novakovic G
The Journal of clinical investigation 2025 Jan 2;135(1)
The Journal of clinical investigation 2025 Jan 2;135(1)
Autophagic signatures in peripheral blood mononuclear cells from Parkinson's disease patients.
Lee MS, Kim JW, Park DG, Heo H, Kim J, Yoon JH, Chang J
Molecules and cells 2025 Feb;48(2):100173
Molecules and cells 2025 Feb;48(2):100173
Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy-Associated Cardiomyopathy.
Guennec BE, Hovhannisyan Y, Revet G, Polat S, Hassani M, Mougenot N, Barthelemy I, Blot S, Cieniewski-Bernard C, Ferry A, Kordeli E, Li Z, Agbulut O
Acta physiologica (Oxford, England) 2025 Dec;241(12):e70117
Acta physiologica (Oxford, England) 2025 Dec;241(12):e70117
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
Lee MS, Son SJ, Kim J, Go S, Hong CH, Roh HW, Chang J
Biomedicines 2025 Dec 23;14(1)
Biomedicines 2025 Dec 23;14(1)
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
Rodwell-Bullock J, Blau E, Ganguly A, Deaton C, Johnson GVW
bioRxiv : the preprint server for biology 2025 Dec 17;
bioRxiv : the preprint server for biology 2025 Dec 17;
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts.
Morsink MAJ, Watkins JM, Zhu K, Zhang X, Luo LJ, Fine BM, Wang BZ, Vunjak-Novakovic G
Journal of molecular and cellular cardiology 2025 Aug;205:13-23
Journal of molecular and cellular cardiology 2025 Aug;205:13-23
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Fang R, Bai L, Verheijen BM, Li B, Dong K, Paulo JA, Zhou M, Chu YC, Song Y, Sherman MY, Gygi S, Field CM, Mitchison TJ, Lu Y
Nature communications 2025 Aug 22;16(1):7852
Nature communications 2025 Aug 22;16(1):7852
Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic.
Ottensmeyer J, Esch A, Baeta H, Sieger S, Gupta Y, Rathmann MF, Jeschke A, Jacko D, Schaaf K, Schiffer T, Rahimi B, Lövenich L, Sisto A, van der Ven PFM, Fürst DO, Haas A, Bloch W, Gehlert S, Hoffmann B, Timmerman V, Huesgen PF, Höhfeld J
Current biology : CB 2024 Sep 23;34(18):4170-4183.e9
Current biology : CB 2024 Sep 23;34(18):4170-4183.e9
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction.
Zhang C, Xu H, Tang Q, Duan Y, Xia H, Huang H, Ye D, Bi F
EMBO reports 2024 Oct;25(10):4488-4514
EMBO reports 2024 Oct;25(10):4488-4514
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Sweeney N, Kim TY, Morrison CT, Li L, Acosta D, Liang J, Datla NV, Fitzgerald JA, Huang H, Liu X, Tan GH, Wu M, Karelina K, Bray CE, Weil ZM, Scharre DW, Serrano GE, Saito T, Saido TC, Beach TG, Kokiko-Cochran ON, Godbout JP, Johnson GVW, Fu H
Acta neuropathologica 2024 Oct 11;148(1):52
Acta neuropathologica 2024 Oct 11;148(1):52
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.
Ohiri JC, Dellefave-Castillo L, Tomar G, Wilsbacher L, Choudhury L, Barefield DY, Fullenkamp D, Gacita AM, Monroe TO, Pesce L, Blancard M, Vaught L, George AL Jr, Demonbreun AR, Puckelwartz MJ, McNally EM
Journal of the American Heart Association 2024 May 21;13(10):e030467
Journal of the American Heart Association 2024 May 21;13(10):e030467
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
Li X, Xiao Y, Li P, Zhu Y, Guo Y, Bian H, Li Z
Journal of Zhejiang University. Science. B 2024 May 15;25(6):485-498
Journal of Zhejiang University. Science. B 2024 May 15;25(6):485-498
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy.
Martin TG, Sherer LA, Kirk JA
American journal of physiology. Heart and circulatory physiology 2024 May 1;326(5):H1124-H1130
American journal of physiology. Heart and circulatory physiology 2024 May 1;326(5):H1124-H1130
BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
Lin H, Sandkuhler S, Dunlea C, Rodwell-Bullock J, King DH, Johnson GVW
Autophagy 2024 Mar;20(3):577-589
Autophagy 2024 Mar;20(3):577-589
Combined Treatment with Bojungikgi-tang (Buzhong Yiqi Decoction) and Riluzole Attenuates Cell Death in TDP-43-Expressing Cells.
Yang EJ
Chinese journal of integrative medicine 2024 Jul;30(7):616-622
Chinese journal of integrative medicine 2024 Jul;30(7):616-622
AZD7762 induces CRBN dependent BAG3 degradation through ubiquitin-proteasome pathway.
Liao Y, Yuan C, Huang M, Si W, Li D, Wu W, Zhang S, Wu R, Quan Y, Yu X, Liao S
Anti-cancer drugs 2024 Jan 1;35(1):46-54
Anti-cancer drugs 2024 Jan 1;35(1):46-54
Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying BAG3 V468M mutation in its BAG domain.
Duboscq-Bidot L, Hoareau B, Ader F, Fontaine V, Villard E
Stem cell research 2024 Feb;74:103294
Stem cell research 2024 Feb;74:103294
Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6.
Shin JW, Kim KH, Lee Y, Choi DE, Lee JM
medRxiv : the preprint server for health sciences 2024 Feb 4;
medRxiv : the preprint server for health sciences 2024 Feb 4;
BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates.
Gong B, Huang Y, Wang Z, Wan B, Zeng Y, Lv C
European journal of medical research 2024 Feb 1;29(1):93
European journal of medical research 2024 Feb 1;29(1):93
2'-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1.
Cheng YH, Chiang CY, Wu CH, Chien CT
International journal of molecular sciences 2024 Dec 2;25(23)
International journal of molecular sciences 2024 Dec 2;25(23)
BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.
Huang X, Guo J, Ning A, Zhang N, Sun Y
Cardiovascular diabetology 2024 Apr 25;23(1):140
Cardiovascular diabetology 2024 Apr 25;23(1):140
BAG3 regulates bone marrow mesenchymal stem cell proliferation by targeting INTS7.
Liu Y, Xu R, Xu J, Wu T, Zhang X
PeerJ 2023;11:e15828
PeerJ 2023;11:e15828
Proteotoxic stress-induced autophagy is regulated by the NRF2 pathway via extracellular vesicles.
Okusha Y, Murshid A, Calderwood SK
Cell stress & chaperones 2023 Mar;28(2):167-175
Cell stress & chaperones 2023 Mar;28(2):167-175
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart.
Wang J, Tomar D, Martin TG, Dubey S, Dubey PK, Song J, Landesberg G, McCormick MG, Myers VD, Merali S, Merali C, Lemster B, McTiernan CF, Khalili K, Madesh M, Cheung JY, Kirk JA, Feldman AM
JACC. Basic to translational science 2023 Jul;8(7):820-839
JACC. Basic to translational science 2023 Jul;8(7):820-839
Functional analysis of a common BAG3 allele associated with protection from heart failure.
Perez-Bermejo JA, Judge LM, Jensen CL, Wu K, Watry HL, Truong A, Ho JJ, Carter M, Runyon WV, Kaake RM, Pulido EH, Mandegar MA, Swaney DL, So PL, Krogan NJ, Conklin BR
Nature cardiovascular research 2023 Jul;2(7):615-628
Nature cardiovascular research 2023 Jul;2(7):615-628
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes.
Samant RS, Batista S, Larance M, Ozer B, Milton CI, Bludau I, Wu E, Biggins L, Andrews S, Hervieu A, Johnston HE, Al-Lazikhani B, Lamond AI, Clarke PA, Workman P
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100485
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100485
BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
Lin H, Sandkuhler S, Dunlea C, King DH, Johnson GVW
bioRxiv : the preprint server for biology 2023 Feb 9;
bioRxiv : the preprint server for biology 2023 Feb 9;
Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta.
Körschgen H, Baeken M, Schmitt D, Nagel H, Behl C
Traffic (Copenhagen, Denmark) 2023 Dec;24(12):564-575
Traffic (Copenhagen, Denmark) 2023 Dec;24(12):564-575
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
Martin TG, Pak H, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies.
Tedesco B, Vendredy L, Adriaenssens E, Cozzi M, Asselbergh B, Crippa V, Cristofani R, Rusmini P, Ferrari V, Casarotto E, Chierichetti M, Mina F, Pramaggiore P, Galbiati M, Piccolella M, Baets J, Baeke F, De Rycke R, Mouly V, Laurenzi T, Eberini I, Vihola A, Udd B, Weiss L, Kimonis V, Timmerman V, Poletti A
Autophagy 2023 Aug;19(8):2217-2239
Autophagy 2023 Aug;19(8):2217-2239
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours.
Chen X, Wang S, Chen Y, Xin H, Zhang S, Wu D, Xue Y, Zha M, Li H, Li K, Gu Z, Wei W, Ping Y
Nature nanotechnology 2023 Aug;18(8):933-944
Nature nanotechnology 2023 Aug;18(8):933-944
Myofibrillar myopathy hallmarks associated with ZAK deficiency.
Stonadge A, Genzor AV, Russell A, Hamed MF, Romero N, Evans G, Pownall ME, Bekker-Jensen S, Blanco G
Human molecular genetics 2023 Aug 26;32(17):2751-2770
Human molecular genetics 2023 Aug 26;32(17):2751-2770
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.
Sheehan PW, Nadarajah CJ, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES
Neuron 2023 Aug 2;111(15):2383-2398.e7
Neuron 2023 Aug 2;111(15):2383-2398.e7
Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis.
Winter L, Staszewska-Daca I, Zittrich S, Elhamine F, Zrelski MM, Schmidt K, Fischer I, Jüngst C, Schauss A, Goldmann WH, Stehle R, Wiche G
Cells 2023 Apr 26;12(9)
Cells 2023 Apr 26;12(9)
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Li Z, Wang T, Xin C, Song Y, Kong J, Xu J, Liu Q, Teng Y, Hou N, Cheng X, Yang G, Liu W, Zhou B, Zhang Y, Yang X, Wang J
International journal of biological sciences 2022;18(5):2018-2031
International journal of biological sciences 2022;18(5):2018-2031
MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration.
Okusha Y, Guerrero-Gimenez ME, Lang BJ, Borges TJ, Stevenson MA, Truman AW, Calderwood SK
Scientific reports 2022 Sep 16;12(1):15582
Scientific reports 2022 Sep 16;12(1):15582
An Important Role for RPRD1B in the Heat Shock Response.
Cugusi S, Bajpe PK, Mitter R, Patel H, Stewart A, Svejstrup JQ
Molecular and cellular biology 2022 Oct 20;42(10):e0017322
Molecular and cellular biology 2022 Oct 20;42(10):e0017322
BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson's disease.
Ying ZM, Lv QK, Yao XY, Dong AQ, Yang YP, Cao YL, Wang F, Gong AP, Liu CF
Annals of translational medicine 2022 Nov;10(22):1218
Annals of translational medicine 2022 Nov;10(22):1218
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
Lu X, Zhang J, Xue P, Wang Q, Wang X, Sun Y, Cui Z
Journal of physiology and biochemistry 2022 May;78(2):427-437
Journal of physiology and biochemistry 2022 May;78(2):427-437
Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles.
Van den Broek B, Wuyts C, Sisto A, Pintelon I, Timmermans JP, Somers V, Timmerman V, Hellings N, Irobi J
Cell communication and signaling : CCS 2022 May 5;20(1):58
Cell communication and signaling : CCS 2022 May 5;20(1):58
Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module.
Patel S, Kumar S, Baldan S, Hesin A, Yaglom J, Sherman MY
iScience 2022 May 20;25(5):104282
iScience 2022 May 20;25(5):104282
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.
Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D
Cell chemical biology 2022 Mar 17;29(3):358-372.e5
Cell chemical biology 2022 Mar 17;29(3):358-372.e5
Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
Chillappagari S, Schwarz J, Kesireddy V, Knoell J, Korfei M, Hoetzenecker K, Schmitz ML, Behl C, Bellusci S, Guenther A, Mahavadi P
Clinical and translational medicine 2022 Jul;12(7):e935
Clinical and translational medicine 2022 Jul;12(7):e935
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
Diao H, Wu K, Lan D, Wang D, Zhao J, Huang B, Shao X, Wang R, Tan H, Tang X, Yan M, Zhang Y
Genes 2022 Jul 26;13(8)
Genes 2022 Jul 26;13(8)
BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, Johnson GVW
Biological psychiatry 2022 Jul 1;92(1):10-24
Biological psychiatry 2022 Jul 1;92(1):10-24
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Zhang C, Tang Q, Xia H, Xu H, Bi F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Martin TG, Delligatti CE, Muntu NA, Stachowski-Doll MJ, Kirk JA
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation.
Liu F, Morderer D, Wren MC, Vettleson-Trutza SA, Wang Y, Rabichow BE, Salemi MR, Phinney BS, Oskarsson B, Dickson DW, Rossoll W
Acta neuropathologica communications 2022 Feb 14;10(1):22
Acta neuropathologica communications 2022 Feb 14;10(1):22
Triangulating variation in the population to define mechanisms for precision management of genetic disease.
Wang C, Anglès F, Balch WE
Structure (London, England : 1993) 2022 Aug 4;30(8):1190-1207.e5
Structure (London, England : 1993) 2022 Aug 4;30(8):1190-1207.e5
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y, Lu CH
American journal of cancer research 2021;11(7):3575-3593
American journal of cancer research 2021;11(7):3575-3593
Locus specific epigenetic modalities of random allelic expression imbalance.
Marion-Poll L, Forêt B, Zielinski D, Massip F, Attia M, Carter AC, Syx L, Chang HY, Gendrel AV, Heard E
Nature communications 2021 Sep 9;12(1):5330
Nature communications 2021 Sep 9;12(1):5330
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
Van Lent J, Verstraelen P, Asselbergh B, Adriaenssens E, Mateiu L, Verbist C, De Winter V, Eggermont K, Van Den Bosch L, De Vos WH, Timmerman V
Brain : a journal of neurology 2021 Sep 4;144(8):2471-2485
Brain : a journal of neurology 2021 Sep 4;144(8):2471-2485
Hsp22 Deficiency Induces Age-Dependent Cardiac Dilation and Dysfunction by Impairing Autophagy, Metabolism, and Oxidative Response.
Wu W, Sun X, Shi X, Lai L, Wang C, Xie M, Qin G, Qiu H
Antioxidants (Basel, Switzerland) 2021 Sep 29;10(10)
Antioxidants (Basel, Switzerland) 2021 Sep 29;10(10)
Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ.
Günay KA, Silver JS, Chang TL, Bednarski OJ, Bannister KL, Rogowski CJ, Olwin BB, Anseth KS
Biomaterials 2021 Oct;277:121097
Biomaterials 2021 Oct;277:121097
Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
Lohanadan K, Molt S, Dierck F, van der Ven PFM, Frey N, Höhfeld J, Fürst DO
Experimental cell research 2021 Nov 15;408(2):112865
Experimental cell research 2021 Nov 15;408(2):112865
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Martin TG, Myers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA
Nature communications 2021 May 19;12(1):2942
Nature communications 2021 May 19;12(1):2942
Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H(2)O(2): implications for HIV-associated neurological disorders.
Duggan MR, Mohseni Ahooyi T, Parikh V, Khalili K
Cell death discovery 2021 Mar 26;7(1):60
Cell death discovery 2021 Mar 26;7(1):60
Overexpression of human BAG3(P209L) in mice causes restrictive cardiomyopathy.
Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M
Nature communications 2021 Jun 11;12(1):3575
Nature communications 2021 Jun 11;12(1):3575
BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.
Martin TG, Tawfik S, Moravec CS, Pak TR, Kirk JA
American journal of physiology. Heart and circulatory physiology 2021 Jun 1;320(6):H2339-H2350
American journal of physiology. Heart and circulatory physiology 2021 Jun 1;320(6):H2339-H2350
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
Jia P, Wu N, Yang H, Guo Y, Guo X, Sun Y
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
TRIM28 functions as a negative regulator of aggresome formation.
Chang J, Hwang HJ, Kim B, Choi YG, Park J, Park Y, Lee BS, Park H, Yoon MJ, Woo JS, Kim C, Park MS, Lee JB, Kim YK
Autophagy 2021 Dec;17(12):4231-4248
Autophagy 2021 Dec;17(12):4231-4248
The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap.
Baldan S, Meriin AB, Yaglom J, Alexandrov I, Varelas X, Xiao ZJ, Sherman MY
Journal of cell science 2021 Dec 1;134(23)
Journal of cell science 2021 Dec 1;134(23)
Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions.
Johari M, Sarparanta J, Vihola A, Jonson PH, Savarese M, Jokela M, Torella A, Piluso G, Said E, Vella N, Cauchi M, Magot A, Magri F, Mauri E, Kornblum C, Reimann J, Stojkovic T, Romero NB, Luque H, Huovinen S, Lahermo P, Donner K, Comi GP, Nigro V, Hackman P, Udd B
Acta neuropathologica 2021 Aug;142(2):375-393
Acta neuropathologica 2021 Aug;142(2):375-393
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction.
Wang Z, Song T, Guo Z, Uwituze LB, Guo Y, Zhang H, Wang H, Zhang X, Pan H, Ji T, Yin F, Zhou S, Dai J, Zhang Z
European journal of medicinal chemistry 2021 Aug 5;220:113452
European journal of medicinal chemistry 2021 Aug 5;220:113452
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, Lp Benesch J
The EMBO journal 2021 Apr 15;40(8):e103811
The EMBO journal 2021 Apr 15;40(8):e103811
Induction of BIS Protein During Astroglial and Fibrotic Scar Formation After Mitochondrial Toxin-Mediated Neuronal Injury in Rats.
Riew TR, Kim S, Jin X, Kim HL, Yoo K, Seo SB, Lee JH, Lee MY
Molecular neurobiology 2020 Sep;57(9):3846-3859
Molecular neurobiology 2020 Sep;57(9):3846-3859
Sprint and Strength Training Modulates Autophagy and Proteostasis in Aging Sprinters.
Hentilä J, Hulmi JJ, Laakkonen EK, Ahtiainen JP, Suominen H, Korhonen MT
Medicine and science in sports and exercise 2020 Sep;52(9):1948-1959
Medicine and science in sports and exercise 2020 Sep;52(9):1948-1959
Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
Schuld J, Orfanos Z, Chevessier F, Eggers B, Heil L, Uszkoreit J, Unger A, Kirfel G, van der Ven PFM, Marcus K, Linke WA, Clemen CS, Schröder R, Fürst DO
Acta neuropathologica communications 2020 Sep 4;8(1):154
Acta neuropathologica communications 2020 Sep 4;8(1):154
The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein.
Torkzaban B, Natarajaseenivasan K, Mohseni Ahooyi T, Shekarabi M, Amini S, Langford TD, Khalili K
Cell death & disease 2020 Oct 8;11(10):835
Cell death & disease 2020 Oct 8;11(10):835
BAG3 Proteomic Signature under Proteostasis Stress.
Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C
Cells 2020 Nov 4;9(11)
Cells 2020 Nov 4;9(11)
BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.
Adriaenssens E, Tedesco B, Mediani L, Asselbergh B, Crippa V, Antoniani F, Carra S, Poletti A, Timmerman V
Scientific reports 2020 May 29;10(1):8755
Scientific reports 2020 May 29;10(1):8755
Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
Reimann L, Schwäble AN, Fricke AL, Mühlhäuser WWD, Leber Y, Lohanadan K, Puchinger MG, Schäuble S, Faessler E, Wiese H, Reichenbach C, Knapp B, Peikert CD, Drepper F, Hahn U, Kreutz C, van der Ven PFM, Radziwill G, Djinović-Carugo K, Fürst DO, Warscheid B
Communications biology 2020 May 22;3(1):253
Communications biology 2020 May 22;3(1):253
An integrative correlation of myopathology, phenotype and genotype in late onset Pompe disease.
Kulessa M, Weyer-Menkhoff I, Viergutz L, Kornblum C, Claeys KG, Schneider I, Plöckinger U, Young P, Boentert M, Vielhaber S, Mawrin C, Bergmann M, Weis J, Ziagaki A, Stenzel W, Deschauer M, Nolte D, Hahn A, Schoser B, Schänzer A
Neuropathology and applied neurobiology 2020 Jun;46(4):359-374
Neuropathology and applied neurobiology 2020 Jun;46(4):359-374
Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
Cao M, Park D, Wu Y, De Camilli P
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 2;117(22):12428-12434
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 2;117(22):12428-12434
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.
Wen X, An P, Li H, Zhou Z, Sun Y, Wang J, Ma L, Lu B
Neuroscience bulletin 2020 Dec;36(12):1414-1428
Neuroscience bulletin 2020 Dec;36(12):1414-1428
Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-Terminal (181)L-(185)L and Plays a Negative Regulation Role during Viral Lytic Infection.
Lyu C, Li WD, Wang SW, Peng JM, Yang YB, Tian ZJ, Cai XH
International journal of molecular sciences 2020 Apr 29;21(9)
International journal of molecular sciences 2020 Apr 29;21(9)
The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.
Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1556-1566
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1556-1566
Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes.
McDermott-Roe C, Lv W, Maximova T, Wada S, Bukowy J, Marquez M, Lai S, Shehu A, Benjamin I, Geurts A, Musunuru K
JCI insight 2019 Nov 14;4(22)
JCI insight 2019 Nov 14;4(22)
Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes.
Ghasemi Tahrir F, Gupta M, Myers V, Gordon J, Cheung JY, Feldman AM, Khalili K
Scientific reports 2019 May 21;9(1):7658
Scientific reports 2019 May 21;9(1):7658
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, Sehn E, Grus F, Wolfrum U, Behl C
Redox biology 2019 Jun;24:101181
Redox biology 2019 Jun;24:101181
Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells.
Mohseni Ahooyi T, Torkzaban B, Shekarabi M, Tahrir FG, Decoppet EA, Cotto B, Langford D, Amini S, Khalili K
Cell death & disease 2019 Jun 17;10(7):473
Cell death & disease 2019 Jun 17;10(7):473
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.
Ji C, Tang M, Zeidler C, Höhfeld J, Johnson GV
Autophagy 2019 Jul;15(7):1199-1213
Autophagy 2019 Jul;15(7):1199-1213
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Fu H, Possenti A, Freer R, Nakano Y, Hernandez Villegas NC, Tang M, Cauhy PVM, Lassus BA, Chen S, Fowler SL, Figueroa HY, Huey ED, Johnson GVW, Vendruscolo M, Duff KE
Nature neuroscience 2019 Jan;22(1):47-56
Nature neuroscience 2019 Jan;22(1):47-56
Imbalances in protein homeostasis caused by mutant desmin.
Winter L, Unger A, Berwanger C, Spörrer M, Türk M, Chevessier F, Strucksberg KH, Schlötzer-Schrehardt U, Wittig I, Goldmann WH, Marcus K, Linke WA, Clemen CS, Schröder R
Neuropathology and applied neurobiology 2019 Aug;45(5):476-494
Neuropathology and applied neurobiology 2019 Aug;45(5):476-494
Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Prado FJ, Shanmughapriya S, Rajan S, Tomar D, Tahrir FG, Gupta MK, Knezevic T, Merabova N, Kontos CD, McClung JM, Klotman PE, Madesh M, Khalili K, Feldman AM
Journal of cellular physiology 2019 Apr;234(4):4432-4444
Journal of cellular physiology 2019 Apr;234(4):4432-4444
Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
Myers VD, Tomar D, Madesh M, Wang J, Song J, Zhang XQ, Gupta MK, Tahrir FG, Gordon J, McClung JM, Kontos CD, Khalili K, Cheung JY, Feldman AM
Journal of cellular physiology 2018 Sep;233(9):6319-6326
Journal of cellular physiology 2018 Sep;233(9):6319-6326
The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
Clemen CS, Winter L, Strucksberg KH, Berwanger C, Türk M, Kornblum C, Florin A, Aguilar-Pimentel JA, Amarie OV, Becker L, Garrett L, Hans W, Moreth K, Neff F, Pingen L, Rathkolb B, Rácz I, Rozman J, Treise I, Fuchs H, Gailus-Durner V, de Angelis MH, Vorgerd M, Eichinger L, Schröder R
Biochemical and biophysical research communications 2018 Sep 18;503(4):2770-2777
Biochemical and biophysical research communications 2018 Sep 18;503(4):2770-2777
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
Tang M, Ji C, Pallo S, Rahman I, Johnson GVW
Neurobiology of aging 2018 Mar;63:128-139
Neurobiology of aging 2018 Mar;63:128-139
Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection.
Palucci I, Matic I, Falasca L, Minerva M, Maulucci G, De Spirito M, Petruccioli E, Goletti D, Rossin F, Piacentini M, Delogu G
Journal of internal medicine 2018 Mar;283(3):303-313
Journal of internal medicine 2018 Mar;283(3):303-313
Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3.
Schänzer A, Rupp S, Gräf S, Zengeler D, Jux C, Akintürk H, Gulatz L, Mazhari N, Acker T, Van Coster R, Garvalov BK, Hahn A
Molecular genetics and metabolism 2018 Mar;123(3):388-399
Molecular genetics and metabolism 2018 Mar;123(3):388-399
Transcriptional upregulation of Bag3, a chaperone-assisted selective autophagy factor, in animal models of KY-deficient hereditary myopathy.
Jokl EJ, Hughes GL, Cracknell T, Pownall ME, Blanco G
Disease models & mechanisms 2018 Jul 6;11(7)
Disease models & mechanisms 2018 Jul 6;11(7)
Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice.
Li C, Ming Y, Hong W, Tang Y, Lei X, Li X, Mao Y
Toxicology letters 2018 Feb;283:69-76
Toxicology letters 2018 Feb;283:69-76
Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
Tahrir FG, Shanmughapriya S, Ahooyi TM, Knezevic T, Gupta MK, Kontos CD, McClung JM, Madesh M, Gordon J, Feldman AM, Cheung JY, Khalili K
Journal of cellular physiology 2018 Feb;233(2):748-758
Journal of cellular physiology 2018 Feb;233(2):748-758
Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy.
Hutt DM, Mishra SK, Roth DM, Larsen MB, Angles F, Frizzell RA, Balch WE
The Journal of biological chemistry 2018 Aug 31;293(35):13682-13695
The Journal of biological chemistry 2018 Aug 31;293(35):13682-13695
HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
Li XC, Hu QK, Chen L, Liu SY, Su S, Tao H, Zhang LN, Sun T, He LJ
International journal of medical sciences 2017;14(13):1335-1341
International journal of medical sciences 2017;14(13):1335-1341
Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K
Frontiers in neuroscience 2017;11:678
Frontiers in neuroscience 2017;11:678
PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.
Ma K, Fu W, Tang M, Zhang C, Hou T, Li R, Lu X, Wang Y, Zhou J, Li X, Zhang L, Wang L, Zhao Y, Zhu WG
Autophagy 2017 Mar 4;13(3):579-591
Autophagy 2017 Mar 4;13(3):579-591
Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex.
Park J, Park Y, Ryu I, Choi MH, Lee HJ, Oh N, Kim K, Kim KM, Choe J, Lee C, Baik JH, Kim YK
Nature communications 2017 Jun 7;8:15730
Nature communications 2017 Jun 7;8:15730
A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR
JCI insight 2017 Jul 20;2(14)
JCI insight 2017 Jul 20;2(14)
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.
Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):62-75
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):62-75
Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.
Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN
PLoS pathogens 2017 Jan;13(1):e1006132
PLoS pathogens 2017 Jan;13(1):e1006132
A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.
Cao YL, Yang YP, Mao CJ, Zhang XQ, Wang CT, Yang J, Lv DJ, Wang F, Hu LF, Liu CF
Neurobiology of aging 2017 Dec;60:104-115
Neurobiology of aging 2017 Dec;60:104-115
Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.
Tahrir FG, Knezevic T, Gupta MK, Gordon J, Cheung JY, Feldman AM, Khalili K
Journal of cellular physiology 2017 Apr;232(4):797-805
Journal of cellular physiology 2017 Apr;232(4):797-805
Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury.
Su F, Myers VD, Knezevic T, Wang J, Gao E, Madesh M, Tahrir FG, Gupta MK, Gordon J, Rabinowitz J, Ramsey FV, Tilley DG, Khalili K, Cheung JY, Feldman AM
JCI insight 2016 Nov 17;1(19):e90931
JCI insight 2016 Nov 17;1(19):e90931
BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.
Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tilley DG, Gao E, Hoffman NE, Tomar D, Madesh M, Rabinowitz J, Koch WJ, Su F, Khalili K, Cheung JY
Journal of molecular and cellular cardiology 2016 Mar;92:10-20
Journal of molecular and cellular cardiology 2016 Mar;92:10-20
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy.
Ghaoui R, Palmio J, Brewer J, Lek M, Needham M, Evilä A, Hackman P, Jonson PH, Penttilä S, Vihola A, Huovinen S, Lindfors M, Davis RL, Waddell L, Kaur S, Yiannikas C, North K, Clarke N, MacArthur DG, Sue CM, Udd B
Neurology 2016 Jan 26;86(4):391-8
Neurology 2016 Jan 26;86(4):391-8
Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing.
Wang BK, Yu XF, Wang JH, Li ZB, Li PH, Wang H, Song L, Chu PK, Li C
Biomaterials 2016 Feb;78:27-39
Biomaterials 2016 Feb;78:27-39
Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D.
Sandell S, Huovinen S, Palmio J, Raheem O, Lindfors M, Zhao F, Haapasalo H, Udd B
Acta neuropathologica communications 2016 Feb 5;4:9
Acta neuropathologica communications 2016 Feb 5;4:9
Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction.
Knezevic T, Myers VD, Su F, Wang J, Song J, Zhang XQ, Gao E, Gao G, Muniswamy M, Gupta MK, Gordon J, Weiner KN, Rabinowitz J, Ramsey FV, Tilley DG, Khalili K, Cheung JY, Feldman AM
JACC. Basic to translational science 2016 Dec;1(7):647-656
JACC. Basic to translational science 2016 Dec;1(7):647-656
Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.
Diaz-Hidalgo L, Altuntas S, Rossin F, D'Eletto M, Marsella C, Farrace MG, Falasca L, Antonioli M, Fimia GM, Piacentini M
Biochimica et biophysica acta 2016 Aug;1863(8):2084-92
Biochimica et biophysica acta 2016 Aug;1863(8):2084-92
The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity.
Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P
Journal of Alzheimer's disease : JAD 2015;44(3):879-96
Journal of Alzheimer's disease : JAD 2015;44(3):879-96
Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J
Autophagy 2015;11(3):538-46
Autophagy 2015;11(3):538-46
BAG3 facilitates the clearance of endogenous tau in primary neurons.
Lei Z, Brizzee C, Johnson GV
Neurobiology of aging 2015 Jan;36(1):241-8
Neurobiology of aging 2015 Jan;36(1):241-8
Myofibrillar instability exacerbated by acute exercise in filaminopathy.
Chevessier F, Schuld J, Orfanos Z, Plank AC, Wolf L, Maerkens A, Unger A, Schlötzer-Schrehardt U, Kley RA, Von Hörsten S, Marcus K, Linke WA, Vorgerd M, van der Ven PF, Fürst DO, Schröder R
Human molecular genetics 2015 Dec 20;24(25):7207-20
Human molecular genetics 2015 Dec 20;24(25):7207-20
Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.
Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Tilley DG, Gao E, Koch WJ, Rabinowitz J, Klotman PE, Khalili K, Feldman AM
Clinical and translational science 2015 Aug;8(4):305-10
Clinical and translational science 2015 Aug;8(4):305-10
Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins.
Vanoli A, Necchi V, Barozzi S, Manca R, Pecci A, Solcia E
Histochemistry and cell biology 2015 Aug;144(2):179-84
Histochemistry and cell biology 2015 Aug;144(2):179-84
WW domain of BAG3 is required for the induction of autophagy in glioma cells.
Merabova N, Sariyer IK, Saribas AS, Knezevic T, Gordon J, Turco MC, Rosati A, Weaver M, Landry J, Khalili K
Journal of cellular physiology 2015 Apr;230(4):831-41
Journal of cellular physiology 2015 Apr;230(4):831-41
Analysis of HDAC6 and BAG3-aggresome pathways in African swine fever viral factory formation.
Muñoz-Moreno R, Barrado-Gil L, Galindo I, Alonso C
Viruses 2015 Apr 8;7(4):1823-31
Viruses 2015 Apr 8;7(4):1823-31
Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy.
Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR
Journal of cellular physiology 2014 Nov;229(11):1697-702
Journal of cellular physiology 2014 Nov;229(11):1697-702
Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics.
Xue L, Wang P, Cao P, Zhu JK, Tao WA
Molecular & cellular proteomics : MCP 2014 Nov;13(11):3199-210
Molecular & cellular proteomics : MCP 2014 Nov;13(11):3199-210
14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.
Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y
Journal of cell science 2013 Sep 15;126(Pt 18):4173-86
Journal of cell science 2013 Sep 15;126(Pt 18):4173-86
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J
Current biology : CB 2013 Mar 4;23(5):430-5
Current biology : CB 2013 Mar 4;23(5):430-5
Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag.
Sariyer IK, Merabova N, Patel PK, Knezevic T, Rosati A, Turco MC, Khalili K
PloS one 2012;7(9):e45000
PloS one 2012;7(9):e45000
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
Sarparanta J, Jonson PH, Golzio C, Sandell S, Luque H, Screen M, McDonald K, Stajich JM, Mahjneh I, Vihola A, Raheem O, Penttilä S, Lehtinen S, Huovinen S, Palmio J, Tasca G, Ricci E, Hackman P, Hauser M, Katsanis N, Udd B
Nature genetics 2012 Feb 26;44(4):450-5, S1-2
Nature genetics 2012 Feb 26;44(4):450-5, S1-2
BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner.
Gentilella A, Khalili K
The Journal of biological chemistry 2011 Mar 18;286(11):9205-15
The Journal of biological chemistry 2011 Mar 18;286(11):9205-15
The Hsc/Hsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells.
Kettern N, Rogon C, Limmer A, Schild H, Höhfeld J
PloS one 2011 Jan 20;6(1):e16398
PloS one 2011 Jan 20;6(1):e16398
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C
EMBO reports 2011 Feb;12(2):149-56
EMBO reports 2011 Feb;12(2):149-56
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J
Current biology : CB 2010 Jan 26;20(2):143-8
Current biology : CB 2010 Jan 26;20(2):143-8
Autoregulation of co-chaperone BAG3 gene transcription.
Gentilella A, Khalili K
Journal of cellular biochemistry 2009 Dec 1;108(5):1117-24
Journal of cellular biochemistry 2009 Dec 1;108(5):1117-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10599-1-AP(BAG3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using BAG3 antibody 10599-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-BAG3 (IP:10599-1-AP, 4ug; Detection:10599-1-AP 1:1000) with K-562 cells lysate 11000ug.
- Sample type
- cell line
