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- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15287-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15287-1-AP, RRID:AB_2248640
- Product name
- HSPB8 antibody
- Antibody type
- Polyclonal
- Description
- HSPB8 antibody (Cat. #15287-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27.
HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction.
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway.
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.
Du W, Guo K, Wang P, Zhong J, Jiang N
Journal of Cancer 2024;15(3):645-658
Journal of Cancer 2024;15(3):645-658
HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction.
Chen L, Wu M, Zhou Y
Experimental and therapeutic medicine 2024 Mar;27(3):114
Experimental and therapeutic medicine 2024 Mar;27(3):114
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway.
Zhang K, Yin W, Ma L, Liu Z, Li Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):1-11
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):1-11
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
Martin TG, Pak H, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
Diao H, Wu K, Lan D, Wang D, Zhao J, Huang B, Shao X, Wang R, Tan H, Tang X, Yan M, Zhang Y
Genes 2022 Jul 26;13(8)
Genes 2022 Jul 26;13(8)
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M
Cell reports 2022 Jul 19;40(3):111092
Cell reports 2022 Jul 19;40(3):111092
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Martin TG, Delligatti CE, Muntu NA, Stachowski-Doll MJ, Kirk JA
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Martin TG, Myers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA
Nature communications 2021 May 19;12(1):2942
Nature communications 2021 May 19;12(1):2942
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.
Ramírez-Rodríguez G, Babu H, Klempin F, Krylyshkina O, Baekelandt V, Gijsbers R, Debyser Z, Overall RW, Nicola Z, Fabel K, Kempermann G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5785-96
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5785-96
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15287-1-AP(HSPB8 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 15287-1-AP(HSPB8 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HSPB8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HSPB8. This antibody recognizes human, mouse, rat antigen. The HSPB8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
