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- References [17]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15287-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15287-1-AP, RRID:AB_2248640
- Product name
- HSPB8 antibody
- Antibody type
- Polyclonal
- Description
- HSPB8 antibody (Cat. #15287-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of ACE and HSPB8 as novel drug targets for LUSC treatment and prognosis based on a prognostic model integrating epigenetic regulation and endoplasmic reticulum stress-related genes.
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5.
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease.
A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy.
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts.
HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27.
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy.
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction.
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway.
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.
Zhou Y, Wang B, Song C, Xie W
PloS one 2026;21(1):e0335395
PloS one 2026;21(1):e0335395
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5.
Du J, Li C, Zhang J, Luo J, Zhang H, Xie S, Chen H, Li X, Qian P
Journal of virology 2025 Oct 23;99(10):e0086825
Journal of virology 2025 Oct 23;99(10):e0086825
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease.
Xia L, Li J, Pang Y, Dai C, Xu M, Du Y, Tian Q, Yi L, Wu B, Chen M, Qiu Y, Cheng C, Wang YT, Song W, Dong Z
Science advances 2025 May 23;11(21):eadt7981
Science advances 2025 May 23;11(21):eadt7981
A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy.
Morsink MAJ, Wang BZ, Watkins JM, Zhuang RZ, Zhang X, Chesnais F, Chen C, Lock RI, Fine BM, Vunjak-Novakovic G
Journal of tissue engineering 2025 Jan-Dec;16:20417314251371296
Journal of tissue engineering 2025 Jan-Dec;16:20417314251371296
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts.
Morsink MAJ, Watkins JM, Zhu K, Zhang X, Luo LJ, Fine BM, Wang BZ, Vunjak-Novakovic G
Journal of molecular and cellular cardiology 2025 Aug;205:13-23
Journal of molecular and cellular cardiology 2025 Aug;205:13-23
HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27.
Du W, Guo K, Wang P, Zhong J, Jiang N
Journal of Cancer 2024;15(3):645-658
Journal of Cancer 2024;15(3):645-658
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy.
Zhou X, Wang M, Sun M, Yao N
Molecular medicine reports 2024 Sep;30(3)
Molecular medicine reports 2024 Sep;30(3)
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.
Ohiri JC, Dellefave-Castillo L, Tomar G, Wilsbacher L, Choudhury L, Barefield DY, Fullenkamp D, Gacita AM, Monroe TO, Pesce L, Blancard M, Vaught L, George AL Jr, Demonbreun AR, Puckelwartz MJ, McNally EM
Journal of the American Heart Association 2024 May 21;13(10):e030467
Journal of the American Heart Association 2024 May 21;13(10):e030467
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
Li X, Xiao Y, Li P, Zhu Y, Guo Y, Bian H, Li Z
Journal of Zhejiang University. Science. B 2024 May 15;25(6):485-498
Journal of Zhejiang University. Science. B 2024 May 15;25(6):485-498
HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction.
Chen L, Wu M, Zhou Y
Experimental and therapeutic medicine 2024 Mar;27(3):114
Experimental and therapeutic medicine 2024 Mar;27(3):114
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway.
Zhang K, Yin W, Ma L, Liu Z, Li Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):1-11
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):1-11
Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
Martin TG, Pak H, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
Journal of the American Heart Association 2023 Dec 19;12(24):e029938
BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation.
Diao H, Wu K, Lan D, Wang D, Zhao J, Huang B, Shao X, Wang R, Tan H, Tang X, Yan M, Zhang Y
Genes 2022 Jul 26;13(8)
Genes 2022 Jul 26;13(8)
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M
Cell reports 2022 Jul 19;40(3):111092
Cell reports 2022 Jul 19;40(3):111092
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Martin TG, Delligatti CE, Muntu NA, Stachowski-Doll MJ, Kirk JA
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Journal of cellular biochemistry 2022 Jan;123(1):128-141
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Martin TG, Myers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA
Nature communications 2021 May 19;12(1):2942
Nature communications 2021 May 19;12(1):2942
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.
Ramírez-Rodríguez G, Babu H, Klempin F, Krylyshkina O, Baekelandt V, Gijsbers R, Debyser Z, Overall RW, Nicola Z, Fabel K, Kempermann G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5785-96
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5785-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15287-1-AP(HSPB8 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 15287-1-AP(HSPB8 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HSPB8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HSPB8. This antibody recognizes human, mouse, rat antigen. The HSPB8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
