ABCC5

gene product
EST277145, MOAT-C, MRP5, SMRP
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
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361 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
130 antibodies
GeneTex
4 antibodies
Novus Biologicals
24 antibodies
Aviva Systems Biology
2 antibodies
Biorbyt
17 antibodies
OriGene
19 antibodies
Abgent
2 antibodies
LifeSpan BioSciences, Inc.
46 antibodies
NovoPro Bioscience Inc.
3 antibodies
Acris Antibodies GmbH
5 antibodies
Affinity Biosciences
1 antibody
Antibodies.com
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
Invitrogen Antibodies
5 antibodies
Arigo
2 antibodies
Enzo Life Sciences
2 antibodies
Abnova Corporation
5 antibodies
ProSci
2 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Diagnostics
3 antibodies
Proteintech Group
1 antibody
Atlas Antibodies
2 antibodies
Creative Biolabs
15 antibodies
MyBioSource
4 antibodies
GenWay
4 antibodies
RayBiotech, Inc.
1 antibody
United States Biological
37 antibodies
Sigma-Aldrich
3 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody