Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10515-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10515-1-AP, RRID:AB_2280966
- Product name
- LASP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LASP1 antibody (Cat. #10515-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis.
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis.
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.
HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance.
Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
LncRNA NEAT1 Knockdown Inhibits Retinoblastoma Progression by miR-3619-5p/LASP1 Axis.
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients.
p21-activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1.
LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion.
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.
Upregulation and hypomethylation of lncRNA AFAP1‑AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer.
Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1.
MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1.
LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.
Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma.
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.
Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis.
You H, Yuan D, Li Q, Zhang N, Kong D, Yu T, Liu X, Liu X, Zhou R, Kong F, Zheng K, Tang R
International journal of biological macromolecules 2023 Jan 31;226:996-1009
International journal of biological macromolecules 2023 Jan 31;226:996-1009
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Tao S, Xie SJ, Diao LT, Lv G, Hou YR, Hu YX, Xu WY, Du B, Xiao ZD
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Hong M, Wu Y, Zhang H, Gu J, Chen J, Guan Y, Qin X, Li Y, Cao J
Frontiers in pharmacology 2022;13:946193
Frontiers in pharmacology 2022;13:946193
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis.
Adachi J, Kakudo A, Takada Y, Isoyama J, Ikemoto N, Abe Y, Narumi R, Muraoka S, Gunji D, Hara Y, Katayama R, Tomonaga T
Life science alliance 2022 Aug;5(8)
Life science alliance 2022 Aug;5(8)
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.
Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, Xu L, Liu Z, Zhao L
Cell death & disease 2021 Oct 6;12(10):911
Cell death & disease 2021 Oct 6;12(10):911
HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance.
Song D, Guo M, Xu S, Song X, Bai B, Li Z, Chen J, An Y, Nie Y, Wu K, Wang S, Zhao Q
Journal of experimental & clinical cancer research : CR 2021 May 14;40(1):170
Journal of experimental & clinical cancer research : CR 2021 May 14;40(1):170
Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
Ma X, Zhang H, Yin H, Geng S, Liu Y, Liu C, Zhao J, Liu Y, Wang X, Wang Y
Brain research bulletin 2021 Jan;166:92-101
Brain research bulletin 2021 Jan;166:92-101
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Walch P, Selkrig J, Knodler LA, Rettel M, Stein F, Fernandez K, Viéitez C, Potel CM, Scholzen K, Geyer M, Rottner K, Steele-Mortimer O, Savitski MM, Holden DW, Typas A
Cell host & microbe 2021 Aug 11;29(8):1316-1332.e12
Cell host & microbe 2021 Aug 11;29(8):1316-1332.e12
LncRNA NEAT1 Knockdown Inhibits Retinoblastoma Progression by miR-3619-5p/LASP1 Axis.
Chen X, Zhao S, Li Q, Xu C, Yu Y, Ge H
Frontiers in genetics 2020;11:574145
Frontiers in genetics 2020;11:574145
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Wu L, Lin W, Liao Q, Wang H, Lin C, Tang L, Lian W, Chen Z, Li K, Xu L, Zhou R, Ding Y, Zhao L
Cell reports 2020 Oct 27;33(4):108327
Cell reports 2020 Oct 27;33(4):108327
LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Pollitt SL, Myers KR, Yoo J, Zheng JQ
Molecular biology of the cell 2020 Nov 15;31(24):2718-2732
Molecular biology of the cell 2020 Nov 15;31(24):2718-2732
Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients.
Plana E, Gálvez L, Medina P, Navarro S, Fornés-Ferrer V, Panadero J, Miralles M
International journal of molecular sciences 2020 Jun 28;21(13)
International journal of molecular sciences 2020 Jun 28;21(13)
p21-activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1.
Huang H, Xue Q, Du X, Cui J, Wang J, Cheng D, Li J, Zheng Y, Huang G, Zhang K, Liu K, Lu J, Zhao J, Chen X, Dong Z, Li X
Molecular carcinogenesis 2020 Dec 1;60(1):38-50
Molecular carcinogenesis 2020 Dec 1;60(1):38-50
LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion.
Yan P, Liu J, Zhou R, Lin C, Wu K, Yang S, Yang S, Zhou J, Xu L, Wang H, Zhao L
Oncogene 2020 Aug;39(35):5743-5755
Oncogene 2020 Aug;39(35):5743-5755
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.
Wang A, Dai H, Gong Y, Zhang C, Shu J, Luo Y, Jiang Y, Liu W, Bie P
Journal of experimental & clinical cancer research : CR 2019 Aug 8;38(1):347
Journal of experimental & clinical cancer research : CR 2019 Aug 8;38(1):347
Upregulation and hypomethylation of lncRNA AFAP1‑AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer.
Bo H, Fan L, Gong Z, Liu Z, Shi L, Guo C, Li X, Liao Q, Zhang W, Zhou M, Xiang B, Li X, Li G, Xiong W, Zeng Z, Cao K, Zhang S, Xiong F
Oncology reports 2019 Apr;41(4):2431-2439
Oncology reports 2019 Apr;41(4):2431-2439
Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
Nicholson L, Lindsay L, Murphy CR
Reproduction, fertility, and development 2018 Oct;30(11):1482-1490
Reproduction, fertility, and development 2018 Oct;30(11):1482-1490
Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.
Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, Wei F, Tang Y, Li X, Liao Q, Wang H, Zhou M, Xiang B, Wu X, Li Y, Li X, Chen X, Li G, Guo C, Zeng Z, Xiong W
Journal of experimental & clinical cancer research : CR 2018 Oct 16;37(1):253
Journal of experimental & clinical cancer research : CR 2018 Oct 16;37(1):253
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Liu Y, Gao Y, Li D, He L, Iw L, Hao B, Chen X, Cao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1.
Wang W, Ji G, Xiao X, Chen X, Qin WW, Yang F, Li YF, Fan LN, Xi WJ, Huo Y, Wen WH, Yang AG, Wang T
Oncotarget 2016 Oct 18;7(42):68674-68687
Oncotarget 2016 Oct 18;7(42):68674-68687
MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1.
Wang LL, Wang L, Wang XY, Shang D, Yin SJ, Sun LL, Ji HB
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):15241-15252
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):15241-15252
LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.
Li Z, Chen Y, Wang X, Zhang H, Zhang Y, Gao Y, Weng M, Wang L, Liang H, Li M, Zhang F, Zhao S, Liu S, Cao Y, Shu Y, Bao R, Zhou J, Liu X, Yan Y, Zhen L, Dong Q, Liu Y
Cancer letters 2016 Mar 28;372(2):239-50
Cancer letters 2016 Mar 28;372(2):239-50
Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma.
Zhang H, Li Z, Chu B, Zhang F, Zhang Y, Ke F, Chen Y, Xu Y, Liu S, Zhao S, Liang H, Weng M, Wu X, Li M, Wu W, Quan Z, Liu Y, Zhang Y, Gong W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):8305-15
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):8305-15
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
Zeng Z, Bo H, Gong Z, Lian Y, Li X, Li X, Zhang W, Deng H, Zhou M, Peng S, Li G, Xiong W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):729-37
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):729-37
The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.
Du YY, Zhao LM, Chen L, Sang MX, Li J, Ma M, Liu JF
Journal of gastroenterology and hepatology 2016 Feb;31(2):384-93
Journal of gastroenterology and hepatology 2016 Feb;31(2):384-93
Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.
Bo H, Gong Z, Zhang W, Li X, Zeng Y, Liao Q, Chen P, Shi L, Lian Y, Jing Y, Tang K, Li Z, Zhou Y, Zhou M, Xiang B, Li X, Yang J, Xiong W, Li G, Zeng Z
Oncotarget 2015 Aug 21;6(24):20404-18
Oncotarget 2015 Aug 21;6(24):20404-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 10515-1-AP(LASP1 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using LASP1 antibody 10515-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10515-1-AP(LASP1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue