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Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB40341 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Kallikrein 12 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Kallikrein 12 in direct ELISAs and Western blots. No cross-reactivity with recombinant human (rh) Kallikrein 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, rhKallikrein beta 1, rhHGF Activator, rhFactor VII, rhFactor X, rhFactor XI, rhThrombin or rhuPA-1 is observed.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin.
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Bin L, Kim BE, Hall CF, Leach SM, Leung DY
The Journal of investigative dermatology 2011 Nov;131(11):2213-22
The Journal of investigative dermatology 2011 Nov;131(11):2213-22
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Memari N, Jiang W, Diamandis EP, Luo LY
Biological chemistry 2007 Apr;388(4):427-35
Biological chemistry 2007 Apr;388(4):427-35
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- Neutralization of Kallikrein 12 Activity by Human Kallikrein 12 Antibody. The cleavage of Boc-VPR-AMC (0.1 mM, Catalog # ES011) by Recombinant Human Kallikrein 12 (0.1 µg/mL, Catalog # 3095-SE) is measured after preincubation with increasing concentrations of Human Kallikrein 12 Monoclonal Antibody (Catalog # MAB40341). The ND50 is typically 0.1 µg/mL.
