17968-1-AP

antibody from Proteintech Group

Targeting: PLAU UPA, URK

Provider product page for 17968-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 17968-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17968-1-AP, RRID:AB_2165202
Product name: uPA/Urokinase antibody
Antibody type: Polyclonal
Description: KD/KO validated uPA/Urokinase antibody (Cat. #17968-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PLAU protein structure - 17968-1-AP shown in red.

Submitted references MicroRNA-181b attenuates lipopolysaccharide-induced inflammatory responses in pulpitis via the PLAU/AKT/NF-κB axis.

Meng T, Liu X, Zhang J, Li S, He W, Li W
International immunopharmacology 2024 Jan 25;127:111451

Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA.

Shi K, Zhou J, Li M, Yan W, Zhang J, Zhang X, Jiang L
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166965

Plasminogen activator urokinase interacts with the fusion protein and antagonizes the growth of Peste des petits ruminants virus.

Wu J, Yang W, Li L, Wu J, He J, Ru Y, Ren J, Wang Y, Zheng H, Shang Y, Li D
Journal of virology 2024 Apr 16;98(4):e0014624

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

Cadinu P, Sivanathan KN, Misra A, Xu RJ, Mangani D, Yang E, Rone JM, Tooley K, Kye YC, Bod L, Geistlinger L, Lee T, Mertens RT, Ono N, Wang G, Sanmarco L, Quintana FJ, Anderson AC, Kuchroo VK, Moffitt JR, Nowarski R
Cell 2024 Apr 11;187(8):2010-2028.e30

PLAU and LAMC2 can predict a poor prognosis in patients with HNSCC.

Guo ZC, Jing SL, Cui H, Xie LY, Na SJ, Tu JB
Journal of Cancer 2023;14(9):1660-1672

Integrated analysis of Dendrobium nobile extract Dendrobin A against pancreatic ductal adenocarcinoma based on network pharmacology, bioinformatics, and validation experiments.

Xu X, Yu Y, Yang L, Wang B, Fan Y, Ruan B, Zhang X, Dai H, Mei W, Jie W, Zheng S
Frontiers in pharmacology 2023;14:1079539

miR-3174 Is a New Tumor Suppressor MicroRNA That Inhibits Several Tumor-Promoting Genes in Glioblastoma.

Hanif F, Zhang Y, Dube C, Gibert MK Jr, Saha S, Hudson K, Marcinkiewicz P, Kefas B, Guessous F, Abounader R
International journal of molecular sciences 2023 May 26;24(11)

Clinicopathological features and immunophenotype of Silva pattern system in endocervical adenocarcinoma.

Zeng C, Wu JK, Lu X
International journal of experimental pathology 2023 Jun;104(3):140-150

Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice.

Kida Y, Okahisa T, Sato Y, Bando M, Fujimoto S, Ma B, Nakagawa T, Kawaguchi T, Nakamura F, Okamoto K, Miyamoto H, Sogabe M, Tsuneyama K, Takayama T
Scientific reports 2023 Feb 18;13(1):2899

PLAU contributes to the development of cholangiocarcinoma via activating NF-κB signaling pathway.

Hu MD, Jia LH, Wang ML
Cell biology international 2023 Aug;47(8):1381-1391

YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.

Zhang C, Chen S, Wang W, Gao Y
Functional & integrative genomics 2023 Aug 8;23(3):269

Role of poFUT1 and O-fucosylation in placental angiogenesis†.

Liang C, Li Y, Qin H, Ramzan MN, Wang H, Liu S, Yan Q
Biology of reproduction 2023 Apr 11;108(4):553-563

Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study.

Chen Y, Xu X, Wang L, Li K, Sun Y, Xiao L, Dai J, Huang M, Wang Y, Wang DW
EBioMedicine 2022 Sep;83:104199

PDGFD switches on stem cell endothelial commitment.

Lu W, Xu P, Deng B, Zhang J, Zhan Y, Lin X, Xu X, Xia Z, Yang X, Zeng X, Huang L, Xie B, Wang C, Wang S, Kuang H, Han X, Mora A, Cao Y, Jiang Q, Li X
Angiogenesis 2022 Nov;25(4):517-533

Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.

Kohara Y, Kitazawa R, Haraguchi R, Imai Y, Kitazawa S
Bone 2022 Jan;154:116200

PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Chen G, Sun J, Xie M, Yu S, Tang Q, Chen L
Frontiers in genetics 2021;12:651882

Identification of an Aging-Related Gene Signature in Predicting Prognosis and Indicating Tumor Immune Microenvironment in Breast Cancer.

Lv W, Zhao C, Tan Y, Hu W, Yu H, Zeng N, Zhang Q, Wu Y
Frontiers in oncology 2021;11:796555

PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma.

Wu K, Mao YY, Han NN, Wu H, Zhang S
Frontiers in oncology 2021;11:574260

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.

Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ
The Journal of experimental medicine 2021 Sep 6;218(9)

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.

Fu H, Gui Y, Liu S, Wang Y, Bastacky SI, Qiao Y, Zhang R, Bonin C, Hargis G, Yu Y, Kreutzer DL, Biswas PS, Zhou Y, Wang Y, Tian XJ, Liu Y, Zhou D
iScience 2021 Oct 22;24(10):103112

RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.

Geng W, Ren J, Shi H, Qin F, Xu X, Xiao S, Jiao Y, Wang A
Journal of cellular physiology 2021 Mar;236(3):2214-2225

p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.

Tan X, Banerjee P, Shi L, Xiao GY, Rodriguez BL, Grzeskowiak CL, Liu X, Yu J, Gibbons DL, Russell WK, Creighton CJ, Kurie JM
Science advances 2021 Jun;7(25)

Urokinase-type Plasminogen Activator Is a Therapeutic Target for Overcoming Sorafenib Resistance in Hepatoma Cells.

Osawa M, Matsuda Y, Kinoshita Y, Wakai T
Anticancer research 2021 Feb;41(2):645-660

Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes.

Zhou X, Li W, Yang J, Qi X, Chen Y, Yang H, Chu L
Aging 2021 Dec 26;13(24):26063-26094

E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects.

Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen XX, Sanderson M, Su Y, Chambers RA, Feghali-Bostwick C
JCI insight 2021 Dec 22;6(24)

MiR-645 promotes invasiveness, metastasis and tumor growth in colorectal cancer by targeting EFNA5.

Li S, Hou X, Wu C, Han L, Li Q, Wang J, Luo S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109889

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.

Li G, Lin J, Peng Y, Qin K, Wen L, Zhao T, Feng Q
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435

NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.

Ma P, Li G, Jiang X, Shen X, Li H, Yang L, Liu W
Aging 2020 Dec 19;13(3):3661-3679

MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression.

Cui Z, Sun S, Liu Q, Zhou X, Gao S, Peng P, Li Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):154-163

Transcriptome sequencing reveals fibrotic associated-genes involved in bovine mammary fibroblasts with Staphylococcus aureus.

Miao Z, Ding Y, Zhao N, Chen X, Cheng H, Wang J, Liu Y, Wang F
The international journal of biochemistry & cell biology 2020 Apr;121:105696

Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.

Wu YJ, Lin SH, Din ZH, Su JH, Liu CI
Marine drugs 2019 Nov 27;17(12)

Rg3 inhibits gemcitabine-induced lung cancer cell invasiveness through ROS-dependent, NF-κB- and HIF-1α-mediated downregulation of PTX3.

Ahmmed B, Kampo S, Khan M, Faqeer A, Kumar SP, Yulin L, Liu JW, Yan Q
Journal of cellular physiology 2019 Jul;234(7):10680-10697

α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression.

Chen H, Xu Z, Li X, Yang Y, Li B, Li Y, Xia K, Wang J, Li S, Wang M, Wu H
Oncogenesis 2018 Mar 13;7(3):28

Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.

Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)

Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.

Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163

Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.

Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S
Oncotarget 2017 Oct 10;8(47):81880-81891

Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation.

Qiao L, Zheng J, Jin X, Wei G, Wang G, Sun X, Li X
Oncology letters 2017 Nov;14(5):5831-5838

Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.

Liu Y, Wang S, Sun D, Liu Y, Liu Y, Wang Y, Liu C, Wu H, Lv Y, Ren Y, Guo X, Sun G, Ma X
Scientific reports 2016 Jul 19;6:29858

Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches.

Su B, Su J, He H, Wu Y, Xia H, Zeng X, Dai W, Ai X, Ling H, Jiang H, Su Q
Oncology reports 2015 May;33(5):2484-94

Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.

Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K
Gastroenterology 2015 Mar;148(3):565-578.e4

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 17968-1-AP(uPA antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The uPA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human uPA. This antibody recognizes human,mouse,rat antigen. The uPA antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17968-1-AP.pdf

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