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LearnPAB3650
antibody from Abnova Corporation
Targeting: SIGLEC7
CD328, p75/AIRM1, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- PAB3650 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB3650, RRID:AB_1580621
- Product name
- SIGLEC7 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of SIGLEC7.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
Nicoll G, Avril T, Lock K, Furukawa K, Bovin N, Crocker PR
European journal of immunology 2003 Jun;33(6):1642-8
European journal of immunology 2003 Jun;33(6):1642-8
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.
Alphey MS, Attrill H, Crocker PR, van Aalten DM
The Journal of biological chemistry 2003 Jan 31;278(5):3372-7
The Journal of biological chemistry 2003 Jan 31;278(5):3372-7
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
Angata T, Varki A
Glycobiology 2000 Apr;10(4):431-8
Glycobiology 2000 Apr;10(4):431-8
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- The SIGLEC7 polyclonal antibody (Cat # PAB3650) is used in Western blot to detect SIGLEC7 in HL-60 cell lysate (lane 1) and in mouse liver tissue lysate (lane 2) .
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with SIGLEC7 polyclonal antibody (Cat # PAB3650) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
